Nogo-B (RTN4) Antibody – Sheep Polyclonal

Nogo: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Cell development/differentiation; Inhibitor; Membrane protein, integral; Motility/polarity/chemotaxis; Endoplasmic reticulum

Cellular Component: neuron projection; protein complex; endoplasmic reticulum; integral to membrane; nuclear envelope; cell projection; membrane; cell soma; cytoplasm; plasma membrane; integral to endoplasmic reticulum membrane; intracellular; myelin sheath

Molecular Function: protein binding; protein complex binding

Biological Process: positive regulation of dopamine secretion; nervous system development; negative regulation of neuron differentiation; cerebral cortex radial glia guided migration; regulation of nervous system development; axonal fasciculation; positive regulation of glial cell differentiation; negative regulation of axonogenesis; angiogenesis; regulation of sensory perception of pain; negative regulation of axon extension; negative regulation of cell growth; regulation of cell migration