JAK3 Antibody – Mouse Monoclonal

JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described.

Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; JakA family

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; membrane; cytoplasm; intracellular; cytosol

Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; kinase activity; protein phosphatase binding; ATP binding; hormone receptor binding; protein kinase activity

Biological Process: positive regulation of immune response; peptidyl-tyrosine phosphorylation; negative regulation of T-helper 1 cell differentiation; negative regulation of FasL biosynthetic process; negative regulation of interleukin-10 production; protein amino acid autophosphorylation; positive regulation of activated T cell proliferation; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; erythrocyte differentiation; positive regulation of T cell proliferation; T cell homeostasis; inflammatory response; negative regulation of interleukin-12 production; cell migration; immune system process; cytokine and chemokine mediated signaling pathway; tyrosine phosphorylation of Stat5 protein; lymph node development; negative regulation of dendritic cell cytokine production; tyrosine phosphorylation of STAT protein; B cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of calcium ion transport; negative regulation of T cell activation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway