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CRHR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624558

CRHR2 is a receptor for corticotropin releasing factor.It Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. More details

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Product Overview

Online Datasheet in PDF
Product Name
CRHR2, Polyclonal Antibody
Full Product Name
CRHR2, NT (Corticotropin-releasing Factor Receptor 2, CRF-R 2, CRF2, Corticotropin-releasing Hormone Receptor 2, CRH-R 2, CRH2R, CRF2R)
Product Gene Name
anti-CRHR2 antibody
Product Synonym Names
Anti -CRHR2, NT (Corticotropin-releasing Factor Receptor 2, CRF-R 2, CRF2, Corticotropin-releasing Hormone Receptor 2, CRH-R 2, CRH2R, CRF2R)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.27% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CRHR2. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
47,688 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (30691559..30739719, complement). Location: 7p14.3
OMIM
602034
3D Structure
ModBase 3D Structure for Q13324
Immunogen
Synthetic peptide selected from the N-terminal region of human CRHR2 (KLH).

Product Categories/Family for anti-CRHR2 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-CRHR2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CRHR2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-CRHR2 antibody

Western blot analysis of CRHR2 Antibody (N-term) in NIH-3T3 cell line lysates (35ug/lane). CRHR2 (arrow) was detected using the purified Pab.
Rabbit Anti-CRHR2 Polyclonal Antibody – Cat# MBS624558

Immunohistochemistry (IHC) of anti-CRHR2 antibody

CRHR2 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRHR2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CRHR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624558

Flow Cytometry (FC/FACS) of anti-CRHR2 antibody

CRHR2 Antibody (N-term) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CRHR2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS624558

Other Notes

Small volumes of anti-CRHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRHR2 purchase

MBS624558 is an antibody targeting CRHR2. Also known as CRHR2, NT (Corticotropin-releasing Factor Receptor 2, CRF-R 2, CRF2, Corticotropin-releasing Hormone Receptor 2, CRH-R 2, CRH2R, CRF2R). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRHR2. It may not necessarily be applicable to this product.

NCBI GI #
321117257
NCBI GeneID
1395
NCBI Accession #
NP_001189412.1
UniProt Primary Accession #
Q13324
UniProt Secondary Accession #
O43461; Q4QRJ4; Q99431
UniProt Related Accession #
Q13324
GenBank Nucleotide #
NM_001202483.1
NCBI Official Full Name
corticotropin-releasing factor receptor 2 isoform 5
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 2
NCBI Official Symbol
CRHR2
NCBI Official Synonym Symbols
CRF2; CRFR2; CRF-RB; HM-CRF
UniProt Protein Name
Corticotropin-releasing factor receptor 2
UniProt Synonym Protein Names
Corticotropin-releasing hormone receptor 2
Protein Family
Corticotropin-releasing factor receptor
UniProt Gene Name
CRHR2
UniProt Synonym Gene Names
CRF2R; CRH2R; CRF-R-2; CRF-R2; CRFR-2; CRH-R-2; CRH-R2
UniProt Entry Name
CRFR2_HUMAN
NCBI Protein Information
corticotropin-releasing factor receptor 2; CRH-R2; CRF2 receptor, beta isoform

NCBI Summary for CRHR2

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
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UniProt Comments for CRHR2

CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; hormone activity; corticotrophin-releasing factor receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of angiogenesis
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Research Articles on CRHR2

1. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence Iowa Gambling Task performance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRHR2 antibody

 Reference Product  PubMed Publications
 CRH antibody  >66 publications with CRHR2 and CRH
 UCN antibody  >19 publications with CRHR2 and UCN
 UCN3 antibody  >9 publications with CRHR2 and UCN3
 POMC antibody  >9 publications with CRHR2 and POMC
 UCN2 antibody  >6 publications with CRHR2 and UCN2
 GHRHR antibody  >1 publications with CRHR2 and GHRHR

Pathways associated with anti-CRHR2 antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-CRHR2 antibody

 Disease Name  Pubmed Publications
 Anxiety Disorders Antibodies  >12 publications with CRHR2 and Anxiety Disorders
 Inflammation Antibodies  >7 publications with CRHR2 and Inflammation
 Weight Gain Antibodies  >4 publications with CRHR2 and Weight Gain
 Depressive Disorder Antibodies  >4 publications with CRHR2 and Depressive Disorder
 Disease Models, Animal Antibodies  >4 publications with CRHR2 and Disease Models, Animal
 Neoplasms Antibodies  >4 publications with CRHR2 and Neoplasms
 Weight Loss Antibodies  >3 publications with CRHR2 and Weight Loss
 Cardiovascular Diseases Antibodies  >3 publications with CRHR2 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with CRHR2 and Carcinoma, Hepatocellular
 Hypertension Antibodies  >3 publications with CRHR2 and Hypertension

Organs/Tissues associated with anti-CRHR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >45 publications with CRHR2 and Brain
 Uterus Antibodies  >1 publications with CRHR2 and Uterus
 Testis Antibodies  >1 publications with CRHR2 and Testis
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