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EIF2AK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624590

GCN2 (EIF2AK4) belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
EIF2AK4, Polyclonal Antibody
Full Product Name
EIF2AK4, NT (9G11) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, GCN2-like Protein, KIAA1338)
Product Gene Name
anti-EIF2AK4 antibody
Product Synonym Names
Anti -EIF2AK4, NT (9G11) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, GCN2-like Protein, KIAA1338)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human GCN2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
186,911 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (40226347..40327797). Location: 15q15.1
OMIM
609280
3D Structure
ModBase 3D Structure for Q9P2K8
Immunogen
Synthetic peptide selected from the C-terminal region with glycine at position 11 of human GCN2 (KLH).

Product Categories/Family for anti-EIF2AK4 antibody

Antibodies; Abs to Translation Initiation Factors
Applications Tested/Suitable for anti-EIF2AK4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EIF2AK4 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-EIF2AK4 antibody

Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies).
Rabbit Anti-EIF2AK4 Polyclonal Antibody – Cat# MBS624590

Immunohistochemistry (IHC) of anti-EIF2AK4 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-EIF2AK4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624590

Other Notes

Small volumes of anti-EIF2AK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EIF2AK4 purchase

MBS624590 is an antibody targeting EIF2AK4. Also known as EIF2AK4, NT (9G11) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, GCN2-like Protein, KIAA1338). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF2AK4. It may not necessarily be applicable to this product.

NCBI GI #
65287717
NCBI GeneID
440275
NCBI Accession #
NP_001013725.2
UniProt Primary Accession #
Q9P2K8
UniProt Secondary Accession #
Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9UJ56; C9JEC4
UniProt Related Accession #
Q9P2K8
GenBank Nucleotide #
NM_001013703.2
NCBI Official Full Name
eukaryotic translation initiation factor 2-alpha kinase 4
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2 alpha kinase 4
NCBI Official Symbol
EIF2AK4
NCBI Official Synonym Symbols
GCN2; KIAA1338
UniProt Protein Name
Eukaryotic translation initiation factor 2-alpha kinase 4
UniProt Synonym Protein Names
GCN2-like protein
Protein Family
eIF-2-alpha kinase
UniProt Gene Name
EIF2AK4
UniProt Synonym Gene Names
GCN2; KIAA1338
UniProt Entry Name
E2AK4_HUMAN
NCBI Protein Information
eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2 eIF2alpha kinase

NCBI Summary for EIF2AK4

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM]

UniProt Comments for EIF2AK4

GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Translation; Protein kinase, Other; EC 2.7.11.1; Other group; PEK family; GCN2 subfamily

Chromosomal Location of Human Ortholog: 15q15.1

Molecular Function: protein serine/threonine kinase activity; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity

Biological Process: unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation

Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive
Show more

Research Articles on EIF2AK4

1. the GCN2/eIF2alpha/ATF4 pathway is essential for the induction of the TRB3 gene transcription

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EIF2AK4 antibody

 Products by Pathway  Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-EIF2AK4 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >4 publications with EIF2AK4 and Liver Diseases
 Neoplasms Antibodies  >3 publications with EIF2AK4 and Neoplasms
 Drug Toxicity Antibodies  >2 publications with EIF2AK4 and Drug Toxicity
 Liver Neoplasms Antibodies  >2 publications with EIF2AK4 and Liver Neoplasms
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1 publications with EIF2AK4 and Encephalomyelitis, Autoimmune, Experimental
 Inflammation Antibodies  >1 publications with EIF2AK4 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with EIF2AK4 and Carcinoma, Hepatocellular
 Insulin Resistance Antibodies  >1 publications with EIF2AK4 and Insulin Resistance
 Fatty Liver Antibodies  >1 publications with EIF2AK4 and Fatty Liver
 Fibrosis Antibodies  >1 publications with EIF2AK4 and Fibrosis

Organs/Tissues associated with anti-EIF2AK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with EIF2AK4 and Blood
 Liver Antibodies  >14 publications with EIF2AK4 and Liver
 Brain Antibodies  >7 publications with EIF2AK4 and Brain
 Muscle Antibodies  >4 publications with EIF2AK4 and Muscle
 Bone Antibodies  >3 publications with EIF2AK4 and Bone
 Spleen Antibodies  >3 publications with EIF2AK4 and Spleen
 Pancreas Antibodies  >3 publications with EIF2AK4 and Pancreas
 Connective Tissue Antibodies  >2 publications with EIF2AK4 and Connective Tissue
 Adipose Tissue Antibodies  >2 publications with EIF2AK4 and Adipose Tissue
 Skin Antibodies  >2 publications with EIF2AK4 and Skin
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