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Keratinocyte Growth Factor (FGF7) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624653

MBS624653 is an antibody targeting FGF7. Also known as Keratinocyte Growth Factor (KGF, Fibroblast Growth Factor 7, FGF-7). Reactive in Human. Host: Rabbit. More details

$785 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Keratinocyte Growth Factor (FGF7), Polyclonal Antibody
Full Product Name
Keratinocyte Growth Factor (KGF, Fibroblast Growth Factor 7, FGF-7)
Product Gene Name
anti-FGF7 antibody
Product Synonym Names
Anti -Keratinocyte Growth Factor (KGF, Fibroblast Growth Factor 7, FGF-7)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with sterile 40-50% glycerol, ddH2O to a concentration of 0.1-1.0mg/ml.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human KGF.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
22,509 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (49715375..49779523). Location: 15q21.2
OMIM
148180
3D Structure
ModBase 3D Structure for P21781
Immunogen
Highly purified (>98%) recombinant antigen.

Product Categories/Family for anti-FGF7 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-FGF7 antibody
ELISA (EL/EIA), Western Blot (WB), Neutralization
Application Notes for anti-FGF7 antibody
Suitable for use in ELISA, Neutralization, and Western Blot.
Dilution: ELISA (Indirect): 0.5-2ug/ml. Using 100ul/well antibody solution. When used in conjunction with the compatible secondary reagents, the detection limit is of 0.2-0.4ng/well.
ELISA (Sandwich): 0.5-2ug/ml. Using 100ul/well antibody solution. When used in conjunction with K1000A, as a detection antibody, the detection limit is of 0.2-0.4ng/well.
Western Blot: 0.1-0.2ug/ml. Used in conjunction with compatible secondary reagents the detection limit is 1.5-3.0ng/lane, under either reducing or non-reducing conditions.
Immunohistochemistry: 0.5ug/ml, overnight at 4 degree C. This antibody stained formalin-fixed, paraffin-embedded sections of normal human skin. An HRP-labeled polymerdetection system was used with a non-alcohol soluble AEC chromogen and a proteinase K antigen retrieval.
Neutralization: 0.56-0.85ug/ml, to yeild one-half maximal inhibition [ND50] of the biological activity of hKGF (25ng/ml).
Optimal dilution determined by the researcher.

Other Notes

Small volumes of anti-FGF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF7. It may not necessarily be applicable to this product.

NCBI GI #
4503705
NCBI GeneID
2252
NCBI Accession #
NP_002000.1
UniProt Primary Accession #
P21781
UniProt Related Accession #
P21781; Q6FGV5; Q6RK68; Q96FG5
GenBank Nucleotide #
NM_002009.3
NCBI Official Full Name
keratinocyte growth factor
NCBI Official Synonym Full Names
fibroblast growth factor 7
NCBI Official Symbol
FGF7
NCBI Official Synonym Symbols
KGF; HBGF-7
UniProt Protein Name
Keratinocyte growth factor
UniProt Synonym Protein Names
Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF7
UniProt Synonym Gene Names
KGF
UniProt Entry Name
FGF7_HUMAN
NCBI Protein Information
keratinocyte growth factor; FGF-7; OTTHUMP00000162252; heparin-binding growth factor 7

NCBI Summary for FGF7

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq]
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UniProt Comments for FGF7

FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: Golgi apparatus; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; epidermis development; hair follicle morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; mesenchymal cell proliferation; signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; actin cytoskeleton reorganization; response to wounding; insulin receptor signaling pathway; innate immune response; positive regulation of epithelial cell proliferation
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Research Articles on FGF7

1. Carcinoma-associated fibroblasts promotes the proliferation of a lingual carcinoma cell line by secreting keratinocyte growth factor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FGF7 antibody

 Reference Product  PubMed Publications
 FGFR2 antibody  >234 publications with FGF7 and FGFR2
 FGFR1 antibody  >56 publications with FGF7 and FGFR1
 FGFR3 antibody  >25 publications with FGF7 and FGFR3
 FGFR4 antibody  >17 publications with FGF7 and FGFR4
 COL1A1 antibody  >1 publications with FGF7 and COL1A1

Pathways associated with anti-FGF7 antibody

 Products by Pathway  Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram
 FGFR2 Ligand Binding And Activation Pathway antibodies  FGFR2 Ligand Binding And Activation Pathway Diagram
 FGFR2b Ligand Binding And Activation Pathway antibodies  FGFR2b Ligand Binding And Activation Pathway Diagram
 FRS2-mediated Cascade Pathway antibodies  FRS2-mediated Cascade Pathway Diagram
 Glypican 3 Network Pathway antibodies  Glypican 3 Network Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-FGF7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >159 publications with FGF7 and Neoplasms
 Carcinoma Antibodies  >68 publications with FGF7 and Carcinoma
 Lung Injury Antibodies  >60 publications with FGF7 and Lung Injury
 Respiratory Tract Diseases Antibodies  >58 publications with FGF7 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >57 publications with FGF7 and Lung Diseases
 Skin Diseases Antibodies  >49 publications with FGF7 and Skin Diseases
 Inflammation Antibodies  >44 publications with FGF7 and Inflammation
 Fibrosis Antibodies  >33 publications with FGF7 and Fibrosis
 Intestinal Diseases Antibodies  >32 publications with FGF7 and Intestinal Diseases
 Mucositis Antibodies  >31 publications with FGF7 and Mucositis

Organs/Tissues associated with anti-FGF7 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >164 publications with FGF7 and Lung
 Skin Antibodies  >151 publications with FGF7 and Skin
 Embryonic Tissue Antibodies  >104 publications with FGF7 and Embryonic Tissue
 Prostate Antibodies  >70 publications with FGF7 and Prostate
 Intestine Antibodies  >67 publications with FGF7 and Intestine
 Bone Antibodies  >61 publications with FGF7 and Bone
 Vascular Antibodies  >46 publications with FGF7 and Vascular
 Kidney Antibodies  >37 publications with FGF7 and Kidney
 Muscle Antibodies  >37 publications with FGF7 and Muscle
 Eye Antibodies  >30 publications with FGF7 and Eye
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