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Phospholipase A2, Secretory, Group Ib (PLA2G1B) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624865

Group IB secretory phospholipase A2 (sPLA2-IB) mediates cell proliferation, cell migration, hormone release and eicosanoid production via its receptor in peripheral tissues. In the CNS, high-affinity binding sites of sPLA2-IB have been documented. sPLA2-IB… More details

$835 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Phospholipase A2, Secretory, Group IB (PLA2G1B), Polyclonal Antibody
Full Product Name
Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2)
Product Gene Name
anti-PLA2G1B antibody
Product Synonym Names
Anti -Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by peptide affinity chromatography.
Specificity
Recognizes human Phospholipase A2, Secretory, Group IB.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
16,360 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (120759914..120765592, complement). Location: 12q24.31
OMIM
172410
3D Structure
ModBase 3D Structure for P04054
Immunogen
Synthetic peptide corresponding to NKAHKNLDTKKYCQS, from the C-Terminus of human Phospholipase A2, Secretory, Group IB (NP_000919.1).
Species Sequence Homology
Canine.
Positive Control
Human Pancreas lysates

Product Categories/Family for anti-PLA2G1B antibody

Antibodies; Abs to Enzymes; Phospholipase
Applications Tested/Suitable for anti-PLA2G1B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PLA2G1B antibody
Suitable for use in ELISA and Western Blot.
Dilution: Peptide ELISA Titer: 1:64,000
Western Blot: 0.01ug/ml; ~17-18kD band observed in Human Pancrease lysates (calcuated MW: 16.4kD according to NP_000919.1). In transfected HEK293 transiently expressing PLAG1B a band of ~18kD is observed. This band is not observed in the non-transfected HEK293.

Chemiluminescence of anti-PLA2G1B antibody

MBS624865 (0.01ug/ml) staining of Human Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-PLA2G1B Polyclonal Antibody – Cat# MBS624865

Testing Data of anti-PLA2G1B antibody

HEK293 overexpressing PLA2G1B and probed with MBS624865 (mock transfection in first lane).
Goat Anti-PLA2G1B Polyclonal Antibody, Testing Data – Cat# MBS624865

Other Notes

Small volumes of anti-PLA2G1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLA2G1B purchase

MBS624865 is an antibody targeting PLA2G1B. Also known as Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for PLA2G1B. It may not necessarily be applicable to this product.

NCBI GI #
4505847
NCBI GeneID
5319
NCBI Accession #
NP_000919.1
UniProt Primary Accession #
P04054
UniProt Secondary Accession #
Q3KPI1; B2R4H5
UniProt Related Accession #
P04054
GenBank Nucleotide #
NM_000928.2
NCBI Official Full Name
phospholipase A2
NCBI Official Synonym Full Names
phospholipase A2, group IB (pancreas)
NCBI Official Symbol
PLA2G1B
NCBI Official Synonym Symbols
PLA2; PLA2A; PPLA2
UniProt Protein Name
Phospholipase A2
UniProt Synonym Protein Names
Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B
Protein Family
Phospholipase
UniProt Gene Name
PLA2G1B
UniProt Synonym Gene Names
PLA2; PLA2A; PPLA2
UniProt Entry Name
PA21B_HUMAN
NCBI Protein Information
phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B

NCBI Summary for PLA2G1B

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
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UniProt Comments for PLA2G1B

PLA2G1B: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.

Protein type: Secreted, signal peptide; Lipid Metabolism - alpha-linolenic acid; Secreted; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - arachidonic acid; Phospholipase; DNA replication; Lipid Metabolism - linoleic acid; EC 3.1.1.4

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space; cell surface; extracellular region; secretory granule

Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; bile acid binding; calcium ion binding; receptor binding

Biological Process: positive regulation of immune response; activation of MAPK activity; activation of phospholipase A2; neutrophil mediated immunity; glucose transport; signal transduction; activation of NF-kappaB transcription factor; phosphatidylcholine metabolic process; positive regulation of fibroblast proliferation; phospholipid metabolic process; fatty acid biosynthetic process; neutrophil chemotaxis; multicellular organismal lipid catabolic process; glycerophospholipid biosynthetic process; actin filament organization; arachidonic acid secretion; leukotriene biosynthetic process; defense response to Gram-positive bacterium; cellular response to insulin stimulus; positive regulation of protein secretion; innate immune response in mucosa; antibacterial humoral response; phosphatidic acid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA replication; interleukin-8 production
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Research Articles on PLA2G1B

1. Exogenously added sPLA(2)-IB decreases phagocytosis of photoreceptor outer segments regardless of enzymatic activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLA2G1B antibody

 Reference Product  PubMed Publications
 PTGS2 antibody  >2 publications with PLA2G1B and PTGS2
 MAPK1 antibody  >1 publications with PLA2G1B and MAPK1

Pathways associated with anti-PLA2G1B antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram

Diseases associated with anti-PLA2G1B antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with PLA2G1B and Inflammation
 Fatty Liver Antibodies  >2 publications with PLA2G1B and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >2 publications with PLA2G1B and Carcinoma, Hepatocellular
 Hypertension Antibodies  >2 publications with PLA2G1B and Hypertension
 Neoplasms Antibodies  >2 publications with PLA2G1B and Neoplasms
 Seizures Antibodies  >2 publications with PLA2G1B and Seizures
 Liver Diseases Antibodies  >2 publications with PLA2G1B and Liver Diseases
 Congenital Abnormalities Antibodies  >1 publications with PLA2G1B and Congenital Abnormalities
 Hemorrhage Antibodies  >1 publications with PLA2G1B and Hemorrhage
 Adenocarcinoma Antibodies  >1 publications with PLA2G1B and Adenocarcinoma

Organs/Tissues associated with anti-PLA2G1B antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >5 publications with PLA2G1B and Pancreas
 Testis Antibodies  >2 publications with PLA2G1B and Testis
 Kidney Antibodies  >1 publications with PLA2G1B and Kidney
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