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TMPRSS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624898

TMPRSS2 is a protein that belongs to the serine protease family. The protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many… More details

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Product Overview

Online Datasheet in PDF
Product Name
TMPRSS2, Polyclonal Antibody
Full Product Name
TMPRSS2, NT (Transmembrane Protease, Serine 2, Serine Protease 10, Transmembrane Protease, Serine 2 Non-catalytic Chain, Transmembrane Protease, Serine 2 Catalytic Chain, PRSS10)
Product Gene Name
anti-TMPRSS2 antibody
Product Synonym Names
Anti -TMPRSS2, NT (Transmembrane Protease, Serine 2, Serine Protease 10, Transmembrane Protease, Serine 2 Non-catalytic Chain, Transmembrane Protease, Serine 2 Catalytic Chain, PRSS10)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human TMPRSS2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
53,859 Da
Chromosome Location
Chromosome: 21; NC_000021.8 (42836478..42880085, complement). Location: 21q22.3
OMIM
602060
3D Structure
ModBase 3D Structure for O15393
Immunogen
Synthetic peptide selected from the N-terminal region of human TMPRSS2 (KLH).

Product Categories/Family for anti-TMPRSS2 antibody

Antibodies; Abs to Enzymes; Protease (Proteinase; Peptidase)
Applications Tested/Suitable for anti-TMPRSS2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TMPRSS2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-TMPRSS2 antibody

Western blot analysis of TMPRSS2 Antibody (N-term) in 293, NCI-H460 cell line lysates (35ug/lane). TMPRSS2 (arrow) was detected using the purified Pab.
Rabbit Anti-TMPRSS2 Polyclonal Antibody – Cat# MBS624898

Immunohistochemistry (IHC) of anti-TMPRSS2 antibody

TMPRSS2 Antibody (N-term) (RB18784) IHC analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TMPRSS2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-TMPRSS2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624898

Flow Cytometry (FC/FACS) of anti-TMPRSS2 antibody

TMPRSS2 Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-TMPRSS2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS624898

Other Notes

Small volumes of anti-TMPRSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMPRSS2 purchase

MBS624898 is an antibody targeting TMPRSS2. Also known as TMPRSS2, NT (Transmembrane Protease, Serine 2, Serine Protease 10, Transmembrane Protease, Serine 2 Non-catalytic Chain, Transmembrane Protease, Serine 2 Catalytic Chain, PRSS10). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TMPRSS2. It may not necessarily be applicable to this product.

NCBI GI #
227499990
NCBI GeneID
7113
NCBI Accession #
NP_001128571.1
UniProt Primary Accession #
O15393
UniProt Secondary Accession #
Q6GTK7; Q9BXX1; B2R8E5; D3DSJ2
UniProt Related Accession #
O15393; Q8WYS7; Q96T73
GenBank Nucleotide #
NM_001135099.1
NCBI Official Full Name
transmembrane protease serine 2 isoform 1
NCBI Official Synonym Full Names
transmembrane protease, serine 2
NCBI Official Symbol
TMPRSS2
NCBI Official Synonym Symbols
PP9284; PRSS10; FLJ41954
UniProt Protein Name
Transmembrane protease serine 2
UniProt Synonym Protein Names
Serine protease 10
Protein Family
Transmembrane protease serine
UniProt Gene Name
TMPRSS2
UniProt Synonym Gene Names
PRSS10
UniProt Entry Name
TMPS2_HUMAN
NCBI Protein Information
transmembrane protease serine 2; epitheliasin; OTTHUMP00000109259; OTTHUMP00000207916; OTTHUMP00000207917; serine protease 10

NCBI Summary for TMPRSS2

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for TMPRSS2

TMPRSS2: a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Protein type: Protease; EC 3.4.21.-; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; scavenger receptor activity

Biological Process: protein autoprocessing; receptor-mediated endocytosis; positive regulation of virion penetration into host cell; proteolysis
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Research Articles on TMPRSS2

1. The authors show that TMPRSS2 might promote viral spread and pathogenesis by diminishing viral recognition by neutralizing antibodies and by activating SARS S for cell-cell and virus-cell fusion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TMPRSS2 antibody

 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with anti-TMPRSS2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >225 publications with TMPRSS2 and Neoplasms
 Urogenital Neoplasms Antibodies  >217 publications with TMPRSS2 and Urogenital Neoplasms
 Prostatic Neoplasms Antibodies  >217 publications with TMPRSS2 and Prostatic Neoplasms
 Carcinoma Antibodies  >59 publications with TMPRSS2 and Carcinoma
 Chromosome Aberrations Antibodies  >38 publications with TMPRSS2 and Chromosome Aberrations
 Adenocarcinoma Antibodies  >32 publications with TMPRSS2 and Adenocarcinoma
 Carcinoma in Situ Antibodies  >21 publications with TMPRSS2 and Carcinoma in Situ
 Prostatic Intraepithelial Neoplasia Antibodies  >18 publications with TMPRSS2 and Prostatic Intraepithelial Neoplasia
 Neoplasms, Hormone-Dependent Antibodies  >15 publications with TMPRSS2 and Neoplasms, Hormone-Dependent
 Cell Transformation, Neoplastic Antibodies  >14 publications with TMPRSS2 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-TMPRSS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >261 publications with TMPRSS2 and Prostate
 Lung Antibodies  >16 publications with TMPRSS2 and Lung
 Kidney Antibodies  >6 publications with TMPRSS2 and Kidney
 Bone Antibodies  >5 publications with TMPRSS2 and Bone
 Pancreas Antibodies  >4 publications with TMPRSS2 and Pancreas
 Liver Antibodies  >4 publications with TMPRSS2 and Liver
 Stomach Antibodies  >3 publications with TMPRSS2 and Stomach
 Bladder Antibodies  >2 publications with TMPRSS2 and Bladder
 Placenta Antibodies  >2 publications with TMPRSS2 and Placenta
 Intestine Antibodies  >2 publications with TMPRSS2 and Intestine
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