• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Munc13-1 (UNC13B) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624931

UNC13A (UNCoordinated 13A; also Munc13-1) is a 190-210kD member of the UNC-13 family, C2 domain protein superfamily of molecules. It is expressed at synaptic junctions, particularly those involved in GABA, acetylcholine and glutamine transmission, and appears… More details

$1030 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Munc13-1 (Unc13b), Polyclonal Antibody
Full Product Name
Munc13-1 (Protein Unc-13 Homolog A, UNC13A, KIAA1032)
Product Gene Name
anti-Unc13b antibody
Product Synonym Names
Anti -Munc13-1 (Protein Unc-13 Homolog A, UNC13A, KIAA1032)
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Human, Mouse
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human UNC13A. Species Crossreactivity: mouse.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
29,781 Da
Chromosome Location
Chromosome: 4; NC_000070.5 (43071856..43277759). Location: 4 B1; 4
3D Structure
ModBase 3D Structure for Q3TTZ7
Immunogen
Purified, E. coli-derived recombinant human UNC13A (aa1613-1786; Accession #Q9UPW8).

Product Categories/Family for anti-Unc13b antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-Unc13b antibody
Western Blot (WB)
Application Notes for anti-Unc13b antibody
Suitable for use in Western Blot.
Dilution: Western Blot:2ug/ml

Other Notes

Small volumes of anti-Unc13b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Unc13b purchase

MBS624931 is an antibody targeting Unc13b. Also known as Munc13-1 (Protein Unc-13 Homolog A, UNC13A, KIAA1032). Reactive in Human, Mouse. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for Unc13b. It may not necessarily be applicable to this product.

NCBI GI #
50582471
NCBI GeneID
22249
UniProt Primary Accession #
Q3TTZ7
UniProt Related Accession #
Q3TTZ7; Q80TM0
NCBI Official Full Name
Munc13-1
NCBI Official Synonym Full Names
unc-13 homolog B (C. elegans)
NCBI Official Symbol
Unc13b
NCBI Official Synonym Symbols
Unc13a; Unc13h1; Unc13h2; Munc13-1; Munc13-2
UniProt Protein Name
Putative uncharacterized protein
Protein Family
Protein
UniProt Gene Name
Unc13b
UniProt Entry Name
Q3TTZ7_MOUSE
NCBI Protein Information
protein unc-13 homolog B; munc13; unc13 homolog 1; UNC-13 homolog 1; unc-13 homolog A; OTTMUSP00000007165

UniProt Comments for Unc13b

UNC13B: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Belongs to the unc-13 family.

Protein type: Lipid-binding

Cellular Component: Golgi apparatus; membrane; cytoplasm; plasma membrane; terminal button; synapse; neuromuscular junction; cytosol; cell junction

Molecular Function: diacylglycerol binding; metal ion binding; non-kinase phorbol ester receptor activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; exocytosis; regulation of short-term neuronal synaptic plasticity; signal transduction; synaptic vesicle priming; neuromuscular junction development; synaptic vesicle docking during exocytosis
Show more

Research Articles on Unc13b

1. Data show that homodimerization of Munc13 inhibits its synaptic vesicle priming function, and RIMs activate priming by disrupting Munc13 homodimerization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Unc13b antibody

 Products by Pathway  Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Synaptic Transmission Pathway antibodies  Synaptic Transmission Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-Unc13b antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with Unc13b and Kidney Diseases
 Fibrosis Antibodies  >2 publications with Unc13b and Fibrosis
 Hematologic Diseases Antibodies  >1 publications with Unc13b and Hematologic Diseases
 Congenital Abnormalities Antibodies  >1 publications with Unc13b and Congenital Abnormalities
 Proteinuria Antibodies  >1 publications with Unc13b and Proteinuria
 Neurobehavioral Manifestations Antibodies  >1 publications with Unc13b and Neurobehavioral Manifestations
 Fever Antibodies  >1 publications with Unc13b and Fever
 Neoplasms Antibodies  >1 publications with Unc13b and Neoplasms
 Brain Diseases Antibodies  >1 publications with Unc13b and Brain Diseases
 Blood Coagulation Disorders Antibodies  >1 publications with Unc13b and Blood Coagulation Disorders

Organs/Tissues associated with anti-Unc13b antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with Unc13b and Brain
 Pancreas Antibodies  >2 publications with Unc13b and Pancreas
 Sympathetic Ganglion Antibodies  >1 publications with Unc13b and Sympathetic Ganglion
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000