Rabbit Anti-CYP4F8 Polyclonal Antibody – Cat# MBS624933

Western blot analysis of anti-CYP4F8 Antibody (C-term) in K562 cell line lysates (35ug/lane). CYP4F8(arrow) was detected using the purified Pab.

CYP4F8 Antibody – Rabbit Polyclonal

Name: CYP4F8 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS624933
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624933

CYP4F8 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CYP4F8, Polyclonal Antibody

Full Product Name

CYP4F8, CT (Cytochrome P450 4F8, CYPIVF8)

Product Gene Name

anti-CYP4F8 antibody

Product Synonym Names

Anti -CYP4F8, CT (Cytochrome P450 4F8, CYPIVF8)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.09% sodium azide.

Purity/Purification

Purified
Purified by ammonium sulfate precipitation.

Specificity

Recognizes human CYP4F8.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

59,995 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (15726029..15740448). Location: 19p13.1

OMIM

611545

3D Structure

ModBase 3D Structure for P98187

Immunogen

Synthetic peptide selected from the C-terminal region of human CYP4F8 (KLH).

Product Categories/Family for anti-CYP4F8 antibody

Antibodies; Abs to Enzymes; Cytochrome

Applications Tested/Suitable for anti-CYP4F8 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CYP4F8 antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Other Notes

Small volumes of anti-CYP4F8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYP4F8 purchase

MBS624933 is an antibody targeting CYP4F8. Also known as CYP4F8, CT (Cytochrome P450 4F8, CYPIVF8). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP4F8. It may not necessarily be applicable to this product.

NCBI GI #

6005737

NCBI GeneID

11283

NCBI Accession #

NP_009184.1

UniProt Primary Accession #

P98187

UniProt Related Accession #

P98187

GenBank Nucleotide #

NM_007253.3

NCBI Official Full Name

cytochrome P450 4F8

NCBI Official Synonym Full Names

cytochrome P450, family 4, subfamily F, polypeptide 8

NCBI Official Symbol

CYP4F8

NCBI Official Synonym Symbols

CPF8; CYPIVF8

UniProt Protein Name

Cytochrome P450 4F8

UniProt Synonym Protein Names

CYPIVF8

Protein Family

Cytochrome

UniProt Gene Name

CYP4F8

UniProt Entry Name

CP4F8_HUMAN

NCBI Protein Information

cytochrome P450 4F8; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IVF, polypeptide 8

NCBI Summary for CYP4F8

This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq]

UniProt Comments for CYP4F8

CYP4F8: Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydrxylation of PGI2 and carbaprostacyclin. Belongs to the cytochrome P450 family.

Protein type: Membrane protein, integral; Oxidoreductase; EC 1.14.14.1

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: iron ion binding; heme binding; alkane 1-monooxygenase activity

Biological Process: xenobiotic metabolic process; icosanoid metabolic process; prostaglandin metabolic process

Research Articles on CYP4F8

1. The PLA2G7, HPGD, EPHX2, and CYP4F8 genes are highly expressed in prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CYP4F8 antibody

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Cytochrome P450 - Arranged By Substrate Type Pathway antibodies	Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
Eicosanoids Pathway antibodies	Eicosanoids Pathway Diagram
Phase 1 - Functionalization Of Compounds Pathway antibodies	Phase 1 - Functionalization Of Compounds Pathway Diagram

Diseases associated with anti-CYP4F8 antibody

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>2 publications with CYP4F8 and Skin Diseases
Psoriasis Antibodies	>2 publications with CYP4F8 and Psoriasis
Ichthyosis Antibodies	>1 publications with CYP4F8 and Ichthyosis

Organs/Tissues associated with anti-CYP4F8 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>3 publications with CYP4F8 and Intestine
Skin Antibodies	>3 publications with CYP4F8 and Skin
Heart Antibodies	>2 publications with CYP4F8 and Heart
Lung Antibodies	>1 publications with CYP4F8 and Lung
Prostate Antibodies	>1 publications with CYP4F8 and Prostate