Tyrosine Hydroxylase (TH) Antibody – Rabbit Polyclonal

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]

TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described.

Protein type: Mitochondrial; Oxidoreductase; Vesicle; Endoplasmic reticulum; EC 1.14.16.2; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: synaptic vesicle; neuron projection; internal side of plasma membrane; smooth endoplasmic reticulum; mitochondrion; cytoplasm; dendrite; melanosome membrane; terminal button; perikaryon; cytoplasmic vesicle; nucleus; cytosol

Molecular Function: amino acid binding; protein domain specific binding; protein binding; enzyme binding; ferric iron binding; ferrous iron binding; dopamine binding; oxygen binding; tyrosine 3-monooxygenase activity

Biological Process: heart morphogenesis; synaptic transmission, dopaminergic; response to peptide hormone stimulus; heart development; response to lipopolysaccharide; locomotory behavior; dopamine biosynthetic process; fatty acid metabolic process; regulation of heart contraction; phytoalexin metabolic process; response to salt stress; response to estradiol stimulus; norepinephrine biosynthetic process; dopamine biosynthetic process from tyrosine; catecholamine biosynthetic process; sensory perception of sound; visual perception; response to electrical stimulus; glycoside metabolic process; epinephrine biosynthetic process; response to pyrethroid; neurotransmitter biosynthetic process; response to corticosterone stimulus; response to nutrient levels; response to light stimulus; anatomical structure morphogenesis; terpene metabolic process; sphingolipid metabolic process; eating behavior; response to amphetamine; phthalate metabolic process; mating behavior; multicellular organismal aging; isoquinoline alkaloid metabolic process; social behavior; response to herbicide; learning; response to ether; synaptic vesicle amine transport; memory; eye photoreceptor cell development; organ morphogenesis; circadian sleep/wake cycle; response to ethanol; pigmentation; response to zinc ion; response to hypoxia; embryonic camera-type eye morphogenesis; response to activity; cerebral cortex development; response to water deprivation

Disease: Segawa Syndrome, Autosomal Recessive