Sheep Anti-DRAXIN Polyclonal Antibody – Cat# MBS625018

Cell lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and immunoblotted with 1ug/ml of MBS625018.

DRAXIN Antibody – Sheep Polyclonal

Name: DRAXIN Antibody; Polyclonal; Sheep; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS625018
Price: 1080 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625018

Draxin (Dorsal repulsive axon guidance protein, neucrin) is a secreted, 58kD, presumable glycoprotein member of the Draxin family of molecules. In mammals, it is expressed in neurons (axons), astroglia, and likely cells of the developing somite. Draxin acts… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Draxin, Polyclonal Antibody

Full Product Name

Draxin (Dorsal Repulsive Axon Guidance Protein, Neucrin)

Product Gene Name

anti-DRAXIN antibody

Product Synonym Names

Anti -Draxin (Dorsal Repulsive Axon Guidance Protein, Neucrin)

Clonality

Polyclonal

Isotype

IgG

Host

Sheep

Species Reactivity

Mouse, Rat

Form/Format

Supplied as lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes mouse Draxin. Shows ~50% crossreactivity with recombinant human Draxin. Species Crossreactivity: rat.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

38,650 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (11751781..11780336). Location: 1p36.22

OMIM

612682

3D Structure

ModBase 3D Structure for Q8NBI3

Immunogen

Recombinant corresponding to aa26-343 from mouse Draxin expressed in NSO cells (Q6PAL1).

Product Categories/Family for anti-DRAXIN antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-DRAXIN antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-DRAXIN antibody

Suitable for use in ELISA and Western Blot.
Dilution: Direct ELISA: 0.5-1ug/ml. The detection limit is ~0.5ng/well.
Western Blot:1ug/ml

Other Notes

Small volumes of anti-DRAXIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DRAXIN purchase

MBS625018 is an antibody targeting DRAXIN. Also known as Draxin (Dorsal Repulsive Axon Guidance Protein, Neucrin). Reactive in Mouse, Rat. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for DRAXIN. It may not necessarily be applicable to this product.

NCBI GI #

86990448

NCBI GeneID

374946

NCBI Accession #

NP_940947.3

UniProt Primary Accession #

Q8NBI3

UniProt Secondary Accession #

Q5SNX0; Q6UWK8; B6EV15

UniProt Related Accession #

Q8NBI3

GenBank Nucleotide #

NM_198545.3

NCBI Official Full Name

draxin

NCBI Official Synonym Full Names

dorsal inhibitory axon guidance protein

NCBI Official Symbol

DRAXIN

NCBI Official Synonym Symbols

UNQ3119; neucrin; AGPA3119; C1orf187

UniProt Protein Name

Draxin

UniProt Synonym Protein Names

Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neucrin

Protein Family

Draxin

UniProt Gene Name

DRAXIN

UniProt Synonym Gene Names

C1orf187

UniProt Entry Name

DRAXI_HUMAN

NCBI Protein Information

draxin; dorsal repulsive axon guidance protein; neural tissue-specific cysteine-rich protein

UniProt Comments for DRAXIN

DRAXIN: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Belongs to the draxin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: extracellular region

Biological Process: dorsal spinal cord development; axon guidance; Wnt receptor signaling pathway; commissural neuron differentiation in the spinal cord; forebrain development; negative regulation of neuron apoptosis; negative regulation of axon extension

Research Articles on DRAXIN

1. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-DRAXIN antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>6 publications with DRAXIN and Brain