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G Protein, Alpha 16 (GNA15) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625035

Ga16 is the only heterotrimeric G proteins with a restricted expression pattern in hematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of Ga16. This G protein is known to couple a large number of G protein-coupled… More details

$590 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
G Protein, alpha 16 (GNA15), Polyclonal Antibody
Full Product Name
G Protein, alpha 16, (Ga16)
Product Gene Name
anti-GNA15 antibody
Product Synonym Names
Anti -G Protein, alpha 16, (Ga16)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Concentration
1mg/ml (lot specific)
Specificity
Reacts with Ga16. Recognizes human Ga16 and mouse Ga15, but not other G proteins.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 19; NC_000019.9 (3136191..3163766). Location: 19p13.3
OMIM
139314
3D Structure
ModBase 3D Structure for P30679
Immunogen
E. coli-expressed human Ga16 (aa237-373)

Product Categories/Family for anti-GNA15 antibody

Antibodies; Abs to G Proteins
Applications Tested/Suitable for anti-GNA15 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-GNA15 antibody
Suitable for use in Western Blot and Immunoprecipitation.
Titer: Western Blot: 1:5000

Other Notes

Small volumes of anti-GNA15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNA15 purchase

MBS625035 is an antibody targeting GNA15. Also known as G Protein, alpha 16, (Ga16). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GNA15. It may not necessarily be applicable to this product.

NCBI GI #
3289983
NCBI GeneID
2769
NCBI Accession #
AAC25616.1
UniProt Primary Accession #
P30679
UniProt Secondary Accession #
O75247; Q53XK2; E9KL40; E9KL47
UniProt Related Accession #
P30679
NCBI Official Full Name
GB15_HUMAN
NCBI Official Synonym Full Names
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
NCBI Official Symbol
GNA15
NCBI Official Synonym Symbols
GNA16
UniProt Protein Name
Guanine nucleotide-binding protein subunit alpha-15
UniProt Synonym Protein Names
Epididymis tissue protein Li 17E; Guanine nucleotide-binding protein subunit alpha-16
Protein Family
Guanine nucleotide-binding protein
UniProt Gene Name
GNA15
UniProt Synonym Gene Names
GNA16; G alpha-15; G-protein subunit alpha-15; G alpha-16
UniProt Entry Name
GNA15_HUMAN
NCBI Protein Information
guanine nucleotide-binding protein subunit alpha-15; g alpha-15; g alpha-16; G-protein subunit alpha-15; G-protein subunit alpha-16; epididymis tissue protein Li 17E; guanine nucleotide-binding protein subunit alpha-16

UniProt Comments for GNA15

G-alpha 15: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Belongs to the G-alpha family. G(q) subfamily.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; GTP binding; G-protein-coupled receptor binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; platelet activation; elevation of cytosolic calcium ion concentration; metabolic process; phospholipase C activation; dopamine receptor, phospholipase C activating pathway; blood coagulation; muscarinic acetylcholine receptor, phospholipase C activating pathway
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Research Articles on GNA15

1. G15 ectopic presence could functionally contribute to the transformation process since siRNA-induced depletion of Galpha15 in pancreatic carcinoma cell lines dramatically inhibited anchorage-independent growth and resistance to the lack of nutrients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GNA15 antibody

 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram

Diseases associated with anti-GNA15 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with GNA15 and Neoplasms

Organs/Tissues associated with anti-GNA15 antibody

 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >1 publications with GNA15 and Uterus
 Kidney Antibodies  >1 publications with GNA15 and Kidney
 Spleen Antibodies  >1 publications with GNA15 and Spleen
 Bone Marrow Antibodies  >1 publications with GNA15 and Bone Marrow
 Liver Antibodies  >1 publications with GNA15 and Liver
 Brain Antibodies  >1 publications with GNA15 and Brain
 Lung Antibodies  >1 publications with GNA15 and Lung
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