• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SECISBP2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625073

MBS625073 is an antibody targeting SECISBP2. Also known as SECISBP2 (SECIS Binding Protein 2, RP11-89K14.1, DKFZp686C09169, SBP2, OTTHUMP00000064929, OTTHUMP00000064930, OTTHUMP00000064931, OTTHUMP00000064932, selenocysteine insertion sequence binding protein… More details

$835 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SECISBP2, Polyclonal Antibody
Full Product Name
SECISBP2 (SECIS Binding Protein 2, RP11-89K14.1, DKFZp686C09169, SBP2, OTTHUMP00000064929, OTTHUMP00000064930, OTTHUMP00000064931, OTTHUMP00000064932, selenocysteine insertion sequence binding protein 2)
Product Gene Name
anti-SECISBP2 antibody
Product Synonym Names
Anti -SECISBP2 (SECIS Binding Protein 2, RP11-89K14.1, DKFZp686C09169, SBP2, OTTHUMP00000064929, OTTHUMP00000064930, OTTHUMP00000064931, OTTHUMP00000064932, selenocysteine insertion sequence binding protein 2)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human SECISBP2. Species sequence homology: canine.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can
Molecular Weight
95,462 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (91933412..91974561). Location: 9q22.2
OMIM
607693
3D Structure
ModBase 3D Structure for Q96T21
Immunogen
A synthetic peptide from the C-terminus of aa-KERQERKQRLQEN.

Product Categories/Family for anti-SECISBP2 antibody

Antibodies; Abs to RNA Processing
Applications Tested/Suitable for anti-SECISBP2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SECISBP2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Peptide ELISA: 1:64,000.
Western Blot: 0.3-1ug/ml. A band is detected at 120kD in HFF cell lysates. Optimal dilutions to be determined by the researcher.

Chemiluminescence of anti-SECISBP2 antibody

MBS625073 staining of HFF cell lysate with B) 100nM siRNA or A) control siRNA. Detected by chemiluminescence. Data kindly provided by Laura Papp and Kum Kum Khanna, Brisbane, Australia.
Goat Anti-SECISBP2 Polyclonal Antibody – Cat# MBS625073

Immunohistochemistry (IHC) of anti-SECISBP2 antibody

MBS625073(3µg/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
Goat Anti-SECISBP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625073

Other Notes

Small volumes of anti-SECISBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SECISBP2. It may not necessarily be applicable to this product.

NCBI GI #
83779010
NCBI GeneID
79048
NCBI Accession #
NP_076982.3
UniProt Primary Accession #
Q96T21
UniProt Secondary Accession #
Q5HYY1; Q8IYC0; Q9H0A1
UniProt Related Accession #
Q4V370; Q59H19; Q5HYY5; Q6AW84; Q7L1Z0; Q96T21; Q9BVI5; Q9H948
GenBank Nucleotide #
NM_024077.3
NCBI Official Full Name
selenocysteine insertion sequence-binding protein 2
NCBI Official Synonym Full Names
SECIS binding protein 2
NCBI Official Symbol
SECISBP2
NCBI Official Synonym Symbols
SBP2; DKFZp686C09169
UniProt Protein Name
Selenocysteine insertion sequence-binding protein 2
Protein Family
Selenocysteine insertion sequence-binding protein
UniProt Gene Name
SECISBP2
UniProt Synonym Gene Names
SBP2
UniProt Entry Name
SEBP2_HUMAN
NCBI Protein Information
selenocysteine insertion sequence-binding protein 2; OTTHUMP00000021618; OTTHUMP00000069896; SECIS-binding protein 2; selenocysteine insertion sequence binding protein 2

NCBI Summary for SECISBP2

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq]
Show more

UniProt Comments for SECISBP2

SECISBP2: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM). This phenotype is associated with a reduction in type II iodothyronine deiodinase activity. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: nucleoplasm; mitochondrion; ribonucleoprotein complex

Molecular Function: ribonucleoprotein binding; mRNA 3'-UTR binding

Biological Process: selenocysteine incorporation

Disease: Thyroid Hormone Metabolism, Abnormal
Show more

Research Articles on SECISBP2

1. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SECISBP2 antibody

 Disease Name  Pubmed Publications
 THYROID HORMONE METABOLISM, ABNORMAL Antibodies  >7 publications with SECISBP2 and THYROID HORMONE METABOLISM, ABNORMAL

Organs/Tissues associated with anti-SECISBP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >15 publications with SECISBP2 and Thyroid
 Blood Antibodies  >7 publications with SECISBP2 and Blood
 Testis Antibodies  >4 publications with SECISBP2 and Testis
 Skin Antibodies  >3 publications with SECISBP2 and Skin
 Liver Antibodies  >3 publications with SECISBP2 and Liver
 Bone Antibodies  >2 publications with SECISBP2 and Bone
 Heart Antibodies  >1 publications with SECISBP2 and Heart
 Muscle Antibodies  >1 publications with SECISBP2 and Muscle
 Kidney Antibodies  >1 publications with SECISBP2 and Kidney
 Brain Antibodies  >1 publications with SECISBP2 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000