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CD137 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6251435

MBS6251435 is an antibody targeting CD137. Also known as CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor Superfamily member 9 precursor)… More details

$1195 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD137, Monoclonal Antibody
Full Product Name
CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor Superfamily member 9 precursor) (PE)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
3H1858
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes mouse CD137 (the mouse homologue of human 4-1BB protein).
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Immunogen
Murine CD137 human Fc fusion protein.
Conjugate
PE

Product Categories/Family for anti-CD137 antibody

Applications Tested/Suitable for anti-CD137 antibody
Flow Cytometry (FC/FACS)

Product References and Citations for anti-CD137 antibody

1. Chu NR; DeBenedette MA; Stiernholm BJ; Barber BH; Watts TH. Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28-T cells. Journal of Immunology, 1997, 158:3081-9. 2. DeBenedette MA; Shahinian A; Mak TW; Watts TH. Costimulation of CD28-T lymphocytes by 4-1BB ligand. Journal of Immunol, 1997, 158:551-9. 3. Hurtado JC; Kim YJ; Kwon BS. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. Journal of Immunology, 1997, 158(6):2600-9. 4. Loo DT; Chalupny NJ; Bajorath J; Shuford WW; Mittler RS; Aruffo A. Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB. Journal of Biological Chemistry, 1997 Mar 7, 272(10):6448-56. 5. Garni-Wagner BA; Lee ZH; Kim YJ; Wilde C; Kang CY; Kwon BS. 4-1BB is expressed on CD45RAhiROhi transitional T cell in humans. Cellular Immunology, 1996, 169(1):91-8. 6. Gruss HJ; Duyster J; Herrmann F. Structural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin's disease. Annals of Oncology, 1996, 7 Suppl 4:19-26. 7. Schwarz H; Blanco FJ; von Kempis J; Valbracht J; Lotz M. ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood, 1996, 87(7):2839-45. 8. Birkeland ML; Copeland NG; Gilbert DJ; Jenkins NA; Barclay AN. Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. European Journal of Immunology, 1995, 25(4):926-30. 9. DeBenedette MA; Chu NR; Pollok KE; Hurtado J; Wade WF; Kwon BS; Watts TH. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. Journal of Experimental Med, 1995, 181:985-92. 10. Gruss HJ; Dower SK. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood, 1995, 85:3378-404. 11. Hurtado JC; Kim SH; Pollok KE; Lee ZH; Kwon BS. Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. Journal of Immunology, 1995 Oct 1, 155(7):3360-7. 12. Katsikis PD; Wunderlich ES; Smith CA; Herzenberg LA; Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. Journal of Experimental Medicine, 1995 Jun 1, 181(6):2029-36. 13. Pollok KE; Kim SH; Kwon BS. Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4. European Journal of Immunology, 1995 Feb, 25(2):488-94. 14. Schwarz H; Valbracht J; Tuckwell J; von Kempis J; Lotz M. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood, 1995 Feb 15, 85(4):1043-52. 15. Setareh M; Schwarz H; Lotz M. A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family. Gene, 1995, 164(2):311-5. 16. Wu Y; Xu J; Shinde S; Grewal I; Henderson T; Flavell RA; Liu Y. Rapid induction of a novel costimulatory activity on B cells by CD40 ligand. Current Biology, 1995, 5(11):1303-11. 17. Zhou Z; Kim S; Hurtado J; Lee ZH; Kim KK; Pollok KE; Kwon BS. Characterization of human homologue of 4-1BB and its ligand. Immunology Letters, 1995, 45(1-2):67-73. 18. Alderson MR. Regulation of immune responses by the ligands for CD27, CD30, and 4-1BB. Circulatory Shock, 1994, 44(2):73-6. 19. Alderson MR; Smith CA; Tough TW; Davis-Smith T; Armitage RJ; Falk B; Roux E; Baker E; Sutherland GR; Din WS; et al. Molecular and biological characterization of human 4-1BB and its ligand. European Journal of Immunology, 1994, 24(9):2219-27. 20. Kwon BS; Kozak CA; Kim KK; Pickard RT. Genomic organization and chromosomal localization of the T-cell antigen 4-1BB. Journal of Immunology, 1994, 152(5):2256-62. 21. Myers SM; Ross GM; Dostaler SM; Anderson MN; Weaver DF; Riopelle RJ. Putative cytoplasmic amphiphilic domains in the nerve growth factor/tumour necrosis factor receptor superfamily. Biochim Biophys Acta, 1994, 1196(1):21-8. 22. Pollok KE; Kim YJ; Hurtado J; Zhou Z; Kim KK; Kwon BS. 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. European Journal of Immunology, 1994, 24(2):367-74. 23. Zhou Z; Pollok KE; Kim KK; Kim YJ; Kwon BS. Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes. Immunology Letters, 1994, 41(2-3):177-84. 24. Goodwin RG; Din WS; Davis-Smith T; Anderson DM; Gimpel SD; Sato TA; Maliszewski CR; Brannan CI; Copeland NG; Jenkins NA; et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. European Journal of Immunology, 1993, 23:2631-41. 25. Gravestein LA; Blom B; Nolten LA; de Vries E; van der Horst G; Ossendorp F; Borst J; Loenen WA. Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. European Journal of Immunology, 1993, 23(4):943-50. 26. Kim YJ; Pollok KE; Zhou Z; Shaw A; Bohlen JB; Fraser M; Kwon BS. Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1. Journal of Immunology, 1993, 151(3):1255-62. 27. Pollok KE; Kim YJ; Zhou Z; Hurtado J; Kim KK; Pickard RT; Kwon BS. Inducible T cell antigen 4-1BB. Analysis of expression and function. Journal of Immunology, 1993, 150(3):771-81. 28. Schwarz H; Tuckwell J; Lotz M. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. Gene, 1993, 134(2):295-8. 29. Chalupny NJ; Peach R; Hollenbaugh D; Ledbetter JA; Farr AG; Aruffo A. T-cell activation molecule 4-1BB binds to extracellular matrix proteins. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89(21):10360-4. 30. Marsters SA; Frutkin AD; Simpson NJ; Fendly BM; Ashkenazi A. Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding. Journal of Biological Chemistry, 1992, 267(9):5747-50. 31. Camerini D; Walz G; Loenen WA; Borst J; Seed B. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. Journal of Immunology, 1991, 147(9):3165-9.

Other Notes

Small volumes of anti-CD137 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD137. It may not necessarily be applicable to this product.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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