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MEK1, MEK2 (MAP2K2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625202

MEK1 and MEK2, also called MAP or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two… More details

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Product Overview

Online Datasheet in PDF
Product Name
MEK1, MEK2 (Map2k2), Polyclonal Antibody
Full Product Name
MEK1, MEK2 (MAPK/ERK Kinase 1, MEK 1, Dual Specificity Mitogen-activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAP2K1, MAPKK 1, MKK1, PRKMK1, ERK Activator Kinase 1 / MAPK/ERK Kinase 2, Dual Specificity Mitogen-activated Protein Kinase Kinase 2, M
Product Gene Name
anti-Map2k2 antibody
Product Synonym Names
Anti -MEK1, MEK2 (MAPK/ERK Kinase 1, MEK 1, Dual Specificity Mitogen-activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAP2K1, MAPKK 1, MKK1, PRKMK1, ERK Activator Kinase 1 / MAPK/ERK Kinase 2, Dual Specificity Mitogen-activated Protein Kinase Kinase 2, M
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
Purity/Purification
Affinity Purified
Purified by Protein A and peptide affinity chromatography.
Specificity
Detects endogenous levels of total MEK1/2 protein. Does not crossreact with related kinases such as SEK (MKK4), MKK3 or MKK6. Species crossreactivity: Human, mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
44,402 Da
Chromosome Location
Chromosome: 10; NC_000076.6 (81105947..81124697). Location: 10 C1; 10 39.72 cM
3D Structure
ModBase 3D Structure for Q63932
Immunogen
Synthetic peptide (KLH coupled) derived from the sequence of human MEK1/2.

Product Categories/Family for anti-Map2k2 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-Map2k2 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-Map2k2 antibody
Suitable for use in ELISA, Western Blotting and Flow Cytometry.
Dilution: Western Blotting: 1:1000
Flow Cytometry: 1:50

Western Blot (WB) of anti-Map2k2 antibody

Western blot analysis of extracts from NIH/3T3 cells, untreated or serum-treated for the indicated times, using MBS625202
Rabbit Anti-MAP2K2 Polyclonal Antibody – Cat# MBS625202

Flow Cytometry (FC/FACS) of anti-Map2k2 antibody

Flow cytometric analysis of Jurkat cells, untreated (blue) or PMA-treated (green), using MBS625202compared to a nonspecific negative control antibody (red).
Rabbit Anti-MAP2K2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS625202

Other Notes

Small volumes of anti-Map2k2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Map2k2 purchase

MBS625202 is an antibody targeting Map2k2. Also known as MEK1, MEK2 (MAPK/ERK Kinase 1, MEK 1, Dual Specificity Mitogen-activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAP2K1, MAPKK 1, MKK1, PRKMK1, ERK Activator Kinase 1 / MAPK/ERK Kinase 2, Dual Specificity Mitogen-activated Protein Kinase Kinase 2, M. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Map2k2. It may not necessarily be applicable to this product.

NCBI GI #
545203
NCBI GeneID
26396
NCBI Accession #
AAC60678.1
UniProt Primary Accession #
Q63932
UniProt Secondary Accession #
Q9D7B0
UniProt Related Accession #
Q63932
NCBI Official Full Name
MEK2
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase 2
NCBI Official Symbol
Map2k2
NCBI Official Synonym Symbols
MK2; MEK2; Prkmk2; AA589381
UniProt Protein Name
Dual specificity mitogen-activated protein kinase kinase 2
UniProt Synonym Protein Names
ERK activator kinase 2; MAPK/ERK kinase 2
Protein Family
Dual specificity mitogen-activated protein kinase kinase
UniProt Gene Name
Map2k2
UniProt Synonym Gene Names
Mek2; Mkk2; Prkmk2; MAP kinase kinase 2; MAPKK 2; MEK 2
UniProt Entry Name
MP2K2_MOUSE
NCBI Protein Information
dual specificity mitogen-activated protein kinase kinase 2; MEK 2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; ERK activator kinase 2; mitogen activated protein kinase kinase 2; protein kinase, mitogen activated, kinase 2, p45

UniProt Comments for Map2k2

MEK2: a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction.

Protein type: EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; Kinase, protein; STE group; STE7 family

Cellular Component: peroxisomal membrane; Golgi apparatus; microtubule; internal side of plasma membrane; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; intercellular junction; cell cortex; cytosol; perinuclear region of cytoplasm; cytoplasm; late endosome; nucleus

Molecular Function: nucleotide binding; PDZ domain binding; protein kinase activity; transferase activity; MAP kinase kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; kinase activity; protein complex scaffold; ATP binding

Biological Process: regulation of axon regeneration; regulation of stress-activated MAPK cascade; activation of MAPK activity; MAPKKK cascade; positive regulation of axonogenesis; phosphorylation; protein amino acid phosphorylation
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Research Articles on Map2k2

1. review focuses on the role of the MEK1 and MEK2 kinases in the development of extraembryonic tissues and in the formation of the placenta

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Map2k2 antibody

 Reference Product  PubMed Publications
 Map2k1 antibody  >356 publications with Map2k2 and Map2k1
 Mapk3 antibody  >147 publications with Map2k2 and Mapk3
 Mapk1 antibody  >146 publications with Map2k2 and Mapk1
 Braf antibody  >59 publications with Map2k2 and Braf
 Raf1 antibody  >14 publications with Map2k2 and Raf1
 Map3k1 antibody  >8 publications with Map2k2 and Map3k1
 Il17rd antibody  >1 publications with Map2k2 and Il17rd

Pathways associated with anti-Map2k2 antibody

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram

Diseases associated with anti-Map2k2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >168 publications with Map2k2 and Neoplasms
 Cardiovascular Diseases Antibodies  >37 publications with Map2k2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >28 publications with Map2k2 and Heart Diseases
 Necrosis Antibodies  >26 publications with Map2k2 and Necrosis
 Inflammation Antibodies  >24 publications with Map2k2 and Inflammation
 Melanoma Antibodies  >24 publications with Map2k2 and Melanoma
 Nervous System Diseases Antibodies  >21 publications with Map2k2 and Nervous System Diseases
 Breast Neoplasms Antibodies  >19 publications with Map2k2 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >14 publications with Map2k2 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >11 publications with Map2k2 and Neoplasm Invasiveness

Organs/Tissues associated with anti-Map2k2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with Map2k2 and Blood
 Heart Antibodies  >34 publications with Map2k2 and Heart
 Skin Antibodies  >32 publications with Map2k2 and Skin
 Lung Antibodies  >31 publications with Map2k2 and Lung
 Brain Antibodies  >25 publications with Map2k2 and Brain
 Liver Antibodies  >17 publications with Map2k2 and Liver
 Kidney Antibodies  >17 publications with Map2k2 and Kidney
 Bone Antibodies  >16 publications with Map2k2 and Bone
 Muscle Antibodies  >11 publications with Map2k2 and Muscle
 Bone Marrow Antibodies  >11 publications with Map2k2 and Bone Marrow
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