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Opioid Receptor, Kappa (OPRK1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625211

MBS625211 is an antibody targeting OPRK1. Also known as Opioid Receptor, kappa (OPRK1, Opioid Receptor, kappa 1, Kappa-type Opioid Receptor, KOR, KOR-1, OPRK). Reactive in Rat. Host: Rabbit. More details

$655 / 5 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Opioid Receptor, kappa (OPRK1), Polyclonal Antibody
Full Product Name
Opioid Receptor, kappa (OPRK1, Opioid Receptor, kappa 1, Kappa-type Opioid Receptor, KOR, KOR-1, OPRK)
Product Gene Name
anti-OPRK1 antibody
Product Synonym Names
Anti -Opioid Receptor, kappa (OPRK1, Opioid Receptor, kappa 1, Kappa-type Opioid Receptor, KOR, KOR-1, OPRK)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a lyophilized powder. Reconstitution with 5.0 ml of TBS/Tween 20.
Purity/Purification
Highly Purified
Purified by precipitation, dialysis and chromatography.
Specificity
Recognizes Kappa Opioid Receptor (346-380). Reactivity of the Kappa Opioid Receptor is ~90%. Does not react to Delta Opioid Receptor and Mu Opioid Receptor. Has been found to stain specifically the kappa opioid receptor in Western blots of whole rat brain homogenates.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding TBS/Tween 20, 2% normal goat serum, 40-50% glycerol. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
42,645 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (54138276..54164194, complement). Location: 8q11.2
OMIM
165196
3D Structure
ModBase 3D Structure for P41145
Immunogen
Peptide analog of the carboxyl terminal of the kappa opioid receptor covalently attached onto a carrier protein.

Product Categories/Family for anti-OPRK1 antibody

Antibodies; Abs to Opioid Receptors; Agonists
Applications Tested/Suitable for anti-OPRK1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-OPRK1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: The stock solution should be further diluted 1:8 with (Note: higher dilutions may be needed) 2% normal goat serum in TBS/Tween-20 as buffer for the primary antibody.

Other Notes

Small volumes of anti-OPRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OPRK1. It may not necessarily be applicable to this product.

NCBI GI #
71533992
NCBI GeneID
4986
UniProt Primary Accession #
P41145
UniProt Secondary Accession #
Q499G4
UniProt Related Accession #
P41145; Q8IWP3
NCBI Official Full Name
Opioid receptor, kappa 1
NCBI Official Synonym Full Names
opioid receptor, kappa 1
NCBI Official Symbol
OPRK1
NCBI Official Synonym Symbols
KOR; OPRK
UniProt Protein Name
Kappa-type opioid receptor
Protein Family
Kappa-type opioid receptor
UniProt Gene Name
OPRK1
UniProt Synonym Gene Names
OPRK
UniProt Entry Name
OPRK_HUMAN
NCBI Protein Information
kappa-type opioid receptor; KOR-1; K-OR-1; OTTHUMP00000226313; OTTHUMP00000226316; kappa opioid receptor; Opiate receptor, kappa-1

UniProt Comments for OPRK1

KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: neuron projection; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; behavior; sensory perception; opioid receptor, adenylate cyclase inhibiting pathway; locomotory behavior; immune response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase inhibiting pathway; regulation of saliva secretion; sensory perception of pain; defense response to virus
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Research Articles on OPRK1

1. because of its stronger binding for hKOPR, GEC1 is able to be recruited by hKOPR sufficiently without membrane association via its C-terminal modification; however, du GABARAP appears to require C-terminal modifications to enhance KOPR expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OPRK1 antibody

 Reference Product  PubMed Publications
 OPRD1 antibody  >12 publications with OPRK1 and OPRD1

Pathways associated with anti-OPRK1 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-OPRK1 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >6 publications with OPRK1 and Pain
 Neoplasms Antibodies  >3 publications with OPRK1 and Neoplasms
 Prostatic Neoplasms Antibodies  >2 publications with OPRK1 and Prostatic Neoplasms
 Anxiety Disorders Antibodies  >1 publications with OPRK1 and Anxiety Disorders

Organs/Tissues associated with anti-OPRK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >2 publications with OPRK1 and Prostate
 Brain Antibodies  >2 publications with OPRK1 and Brain
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