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CD41 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6252532

MBS6252532 is an antibody targeting CD41. Also known as CD41 (CD41 Antigen, CD41b, gp2b, GPalphaIIb, GPIIb, Gta, HPA3, HPA-3, Integrin alpha IIb, Integrin alpha 2b, ITGA2B, ITGAB, Platelet Glycoprotein IIb of IIb/IIIa Complex, Platelet Fibrinogen Receptor… More details

$905 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD41, Monoclonal Antibody
Full Product Name
CD41 (CD41 Antigen, CD41b, gp2b, GPalphaIIb, GPIIb, Gta, HPA3, HPA-3, Integrin alpha IIb, Integrin alpha 2b, ITGA2B, ITGAB, Platelet Glycoprotein IIb of IIb/IIIa Complex, Platelet Fibrinogen Receptor alpha, Platelet Membrane Glycoprotein IIb, Platelet spe
Product Gene Name
Product Synonym Names
Antigen CD41
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3H1299
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight405.
Purity/Purification
Purified by protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes human CD41. Not established if this antibody recognizes free human CD41 or human CD41 only when complexed with CD61. Antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex. Species Crossreactivity: baboon, mink and mustelid.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
1039
Chromosome Location
Chromosome: 17; NC_000017.10 (42449550..42466873, complement). Location: 17q21.32
OMIM
273800
3D Structure
ModBase 3D Structure for P08514
Immunogen
Human platelet plasma membrane.
Conjugate
MaxLight405

Product Categories/Family for anti-CD41 antibody

Applications Tested/Suitable for anti-CD41 antibody
Flow Cytometry (FC/FACS)

Testing Data of anti-CD41 antibody

Staining of human peripheral blood platelets with moue anti-human CD4 (ALEXA 647).
Mouse Anti-CD41 Monoclonal Antibody – Cat# MBS6252532

Testing Data of anti-CD41 antibody

Staining of human peripheral blood platelets with C2394-04E.
Mouse Anti-CD41 Monoclonal Antibody, Testing Data – Cat# MBS6252532

Testing Data of anti-CD41 antibody

Staining of human peripheral blood platelets with C2394-04F.
Mouse Anti-CD41 Monoclonal Antibody, Testing Data – Cat# MBS6252532

Testing Data of anti-CD41 antibody

Staining of human peripheral blood platelets with C2394-04G.
Mouse Anti-CD41 Monoclonal Antibody, Testing Data – Cat# MBS6252532

Product References and Citations for anti-CD41 antibody

1. Hornby, E.J. et al. (1991) Activation of human platelets by exposure to a monoclonal, PM6/248, to glycoprotein IIb-IIIa. Br. J. Haematol. 79: 277-285. 2. Michelson, A.D. et al. (1995) A panel of platelet mAb for the study of haemostasis and thrombosis in baboons. Leukocyte Typing V. Oxford University Press p 1230-1231. 3. Maloney, S.F. ety al. (2010) P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Integr Biol (Camb). 2: 183-92. 4. Aasted, B. et al. (2007) Reactivity of monoclonal antibodies to human CD antigens with cells from mink. Vet Immunol Immunopathol. 119: 27-37. 5. Massoudy, P. et al. (2001) Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass. Chest. 119: 31-6. 6. Kahng, J. et al. (2008) Quantitative comparisons of antibody-binding sites of platelet glycoprotein IIb/IIIa in aplastic anemia and idiopathic thrombocytopenic purpura. Ann Clin Lab Sci. 38: 6-11. 7. Chae, H. et al. (2009) EDTA Inhibits the Binding of Clone 96.2C1, an Anti-CD41a Monoclonal Antibody, to the Platelets and Addition of Heparin and CaCl2 to the Antibody Neutralizes the EDTA-induced Inhibitory Effect Korean J Hematol 44: 42 - 6. 8. Zahler, S. et al. (1999) Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass. Cardiovasc Res. 41: 722-30. 9. Wang, J.S. et al. (2005) Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men. Arterioscler Thromb Vasc Biol. 25: 454-60. 10. Welsh, J.D. et al. (2012) Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. J Thromb Haemost. Sep 15.

Other Notes

Small volumes of anti-CD41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD41. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
integrin alpha-IIb preproprotein
NCBI Official Synonym Full Names
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
NCBI Official Symbol
ITGA2B
NCBI Official Synonym Symbols
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb
Protein Family
UniProt Gene Name
ITGA2B
UniProt Synonym Gene Names
GP2B; ITGAB; GPIIb
UniProt Entry Name
ITA2B_HUMAN
NCBI Protein Information
integrin alpha-IIb; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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