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CRKL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625262

CrkL is a 39kD adaptor protein, originally cloned in proximity to the BCR gene on chromosome 22, which has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII. Structurally, the amino-terminal SH3… More details

$510 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
CrkL, Polyclonal Antibody
Full Product Name
CrkL (Crk-like Protein, CRKL)
Product Gene Name
anti-CRKL antibody
Product Synonym Names
Anti -CrkL (Crk-like Protein, CRKL)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CrkL. Species Cross-Reactivity: mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
33,777 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (21271714..21308037). Location: 22q11; 22q11.21
OMIM
602007
3D Structure
ModBase 3D Structure for P46109
Immunogen
Synthetic non-phosphopeptide corresponding to human CrkL around the phosphorylation site of tyrosine 207.

Product Categories/Family for anti-CRKL antibody

Antibodies; Abs to Disease Markers
Applications Tested/Suitable for anti-CRKL antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CRKL antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA:1:20,000
Western Blot:1:500-1:1,000
Immunohistochemistry:1:50-1:100

Other Notes

Small volumes of anti-CRKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRKL purchase

MBS625262 is an antibody targeting CRKL. Also known as CrkL (Crk-like Protein, CRKL). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRKL. It may not necessarily be applicable to this product.

NCBI GI #
4885153
NCBI GeneID
1399
NCBI Accession #
NP_005198.1
UniProt Primary Accession #
P46109
UniProt Secondary Accession #
A8KA44; D3DX35
UniProt Related Accession #
P46109
GenBank Nucleotide #
NM_005207.3
NCBI Official Full Name
crk-like protein
NCBI Official Synonym Full Names
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
NCBI Official Symbol
CRKL
UniProt Protein Name
Crk-like protein
Protein Family
Crk-like protein
UniProt Gene Name
CRKL
UniProt Entry Name
CRKL_HUMAN
NCBI Protein Information
crk-like protein; OTTHUMP00000198538; OTTHUMP00000198539

NCBI Summary for CRKL

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
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UniProt Comments for CRKL

CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; endosome

Molecular Function: signal transducer activity; protein binding; SH3/SH2 adaptor activity

Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; activation of MAPKK activity; thymus development; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
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Research Articles on CRKL

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRKL antibody

 Reference Product  PubMed Publications
 BCR antibody  >142 publications with CRKL and BCR
 CRK antibody  >122 publications with CRKL and CRK
 CBL antibody  >66 publications with CRKL and CBL
 GRB2 antibody  >47 publications with CRKL and GRB2
 CD34 antibody  >25 publications with CRKL and CD34
 LYN antibody  >17 publications with CRKL and LYN
 SYK antibody  >11 publications with CRKL and SYK
 DAB1 antibody  >10 publications with CRKL and DAB1
 BCAR1 antibody  >8 publications with CRKL and BCAR1
 SHC1 antibody  >8 publications with CRKL and SHC1

Pathways associated with anti-CRKL antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Down-stream Signal Transduction Pathway antibodies  Down-stream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram

Diseases associated with anti-CRKL antibody

 Disease Name  Pubmed Publications
 Leukemia Antibodies  >114 publications with CRKL and Leukemia
 Neoplasms Antibodies  >113 publications with CRKL and Neoplasms
 Leukemia, Myeloid Antibodies  >86 publications with CRKL and Leukemia, Myeloid
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >69 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Cell Transformation, Neoplastic Antibodies  >26 publications with CRKL and Cell Transformation, Neoplastic
 Leukemia, Myeloid, Acute Antibodies  >10 publications with CRKL and Leukemia, Myeloid, Acute
 Abnormalities, Multiple Antibodies  >8 publications with CRKL and Abnormalities, Multiple
 Heart Defects, Congenital Antibodies  >8 publications with CRKL and Heart Defects, Congenital
 Craniofacial Abnormalities Antibodies  >8 publications with CRKL and Craniofacial Abnormalities
 DiGeorge Syndrome Antibodies  >8 publications with CRKL and DiGeorge Syndrome

Organs/Tissues associated with anti-CRKL antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >93 publications with CRKL and Blood
 Bone Antibodies  >17 publications with CRKL and Bone
 Bone Marrow Antibodies  >16 publications with CRKL and Bone Marrow
 Nerve Antibodies  >14 publications with CRKL and Nerve
 Brain Antibodies  >11 publications with CRKL and Brain
 Embryonic Tissue Antibodies  >9 publications with CRKL and Embryonic Tissue
 Lung Antibodies  >7 publications with CRKL and Lung
 Liver Antibodies  >4 publications with CRKL and Liver
 Parathyroid Antibodies  >4 publications with CRKL and Parathyroid
 Thymus Antibodies  >4 publications with CRKL and Thymus
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