Zinc Transporter ZIP1 (SLC39A1) Antibody – Rabbit Polyclonal

Zinc is an essential nutrient for all organisms because of the many important roles this metal plays. Movement of zinc into and out of cells and subcellular organelles is mediated by zinc transporter proteins. In many organisms, zinc uptake is mediated by members of the ZIP family of metal ion transporters. In mammals, the Zip1, Zip2, Zip3, Zip4, Zip5, LIV- 1 (Zip6), KE4 (Zip7), and BIGM103 (Zip8) proteins have been implicated in zinc uptake in a variety of cell and tissue types.

Zip1 (SLC39A1; IRT1; ZIRTL) was found in a human EST database by its homology with Arabidopsis Zip1 transporter. The 34kD human ZIP1, with 324aa residues is located at chromosome 1q21. The human and mouse ZIP1 proteins ZIP1 has a predicted topology of eight transmembrane domains (TMDs) and a leucine zipper DNA-binding motif. Overexpression of human or mouse ZIP1 has demonstrated the 65Zn uptake enhancing properties of Zip1.

Small volumes of anti-SLC39A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS625308 is an antibody targeting SLC39A1. Also known as Anti-Zinc Transporter ZIP1 (Solute Carrier Family 39 Member 1, Zinc-iron-regulated Transporter-like, Zrt- and Irt-like Protein 1, ZIP-1, hZIP1, SLC39A1, IRT1, ZIP1, ZIRTL, CGI-08, CGI-71). Reactive in Human; Mouse. Host: Rabbit.