Rabbit Anti-PANK1 Polyclonal Antibody – Cat# MBS625341

Western blot analysis of hPANK1-R90 in MCF-7 cell line and mouse spleen tissue lysates (35ug/lane). PANK1 (arrow) was detected using the purified Pab.

Pantothenate Kinase 1 (PANK1) Antibody – Rabbit Polyclonal

Name: PANK1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS625341
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625341

PANK1 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Pantothenate Kinase 1 (PANK1), Polyclonal Antibody

Full Product Name

Pantothenate Kinase 1, NT (Pantothenic Acid Kinase 1, PANK1, PANK1a, PANK1b, PANK, hPanK1, hPanK, MGC24596)

Product Gene Name

anti-PANK1 antibody

Product Synonym Names

Anti -Pantothenate Kinase 1, NT (Pantothenic Acid Kinase 1, PANK1, PANK1a, PANK1b, PANK, hPanK1, hPanK, MGC24596)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human PANK1. Species Crossreactivity: mouse.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

64,339 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (91342749..91405215, complement). Location: 10q23.31

OMIM

606160

3D Structure

ModBase 3D Structure for Q8TE04

Immunogen

Synthetic peptide selected from the N-terminal region of human PANK1 (KLH).

Product Categories/Family for anti-PANK1 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-PANK1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-PANK1 antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Other Notes

Small volumes of anti-PANK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PANK1 purchase

MBS625341 is an antibody targeting PANK1. Also known as Pantothenate Kinase 1, NT (Pantothenic Acid Kinase 1, PANK1, PANK1a, PANK1b, PANK, hPanK1, hPanK, MGC24596). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PANK1. It may not necessarily be applicable to this product.

NCBI GI #

55957270

NCBI GeneID

53354

UniProt Primary Accession #

Q8TE04

UniProt Secondary Accession #

Q7RTX6; Q7Z495; Q8TBQ8; A6NIP0

UniProt Related Accession #

Q8TE04

NCBI Official Full Name

pantothenate kinase 1

NCBI Official Synonym Full Names

pantothenate kinase 1

NCBI Official Symbol

PANK1

NCBI Official Synonym Symbols

PANK; MGC24596

UniProt Protein Name

Pantothenate kinase 1

UniProt Synonym Protein Names

Pantothenic acid kinase 1

Protein Family

Pantothenate kinase

UniProt Gene Name

PANK1

UniProt Synonym Gene Names

PANK

UniProt Entry Name

PANK1_HUMAN

NCBI Protein Information

pantothenate kinase 1; OTTHUMP00000020071; OTTHUMP00000020072; pantothenic acid kinase 1

NCBI Summary for PANK1

This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq]

UniProt Comments for PANK1

PANK1: Plays a role in the physiological regulation of the intracellular CoA concentration. Belongs to the type II pantothenate kinase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.33; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Kinase, other

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: recycling endosome; clathrin coat; cytosol; nucleus

Molecular Function: pantothenate kinase activity; ATP binding

Biological Process: coenzyme biosynthetic process; coenzyme A biosynthetic process; vitamin metabolic process; pantothenate metabolic process; phosphorylation; water-soluble vitamin metabolic process

Research Articles on PANK1

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PANK1 antibody

Products by Pathway	Pathway Diagram
Coenzyme A Biosynthesis Pathway antibodies	Coenzyme A Biosynthesis Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Of Vitamins And Cofactors Pathway antibodies	Metabolism Of Vitamins And Cofactors Pathway Diagram
Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies	Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
Pantothenate And CoA Biosynthesis Pathway antibodies	Pantothenate And CoA Biosynthesis Pathway Diagram
Pantothenate And CoA Biosynthesis Pathway antibodies	Pantothenate And CoA Biosynthesis Pathway Diagram
Vitamin B5 (pantothenate) Metabolism Pathway antibodies	Vitamin B5 (pantothenate) Metabolism Pathway Diagram

Diseases associated with anti-PANK1 antibody

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>1 publications with PANK1 and Liver Diseases
Hyperglycemia Antibodies	>1 publications with PANK1 and Hyperglycemia
Central Nervous System Diseases Antibodies	>1 publications with PANK1 and Central Nervous System Diseases
Neurodegenerative Diseases Antibodies	>1 publications with PANK1 and Neurodegenerative Diseases
Fatty Liver Antibodies	>1 publications with PANK1 and Fatty Liver

Organs/Tissues associated with anti-PANK1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>1 publications with PANK1 and Liver
Brain Antibodies	>1 publications with PANK1 and Brain