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PACSIN3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625347

A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane. It was originally characterized as a presynaptically… More details

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Product Overview

Online Datasheet in PDF
Product Name
PACSIN3, Polyclonal Antibody
Full Product Name
PACSIN3 (Protein Kinase C and Casein Kinase Substrate in Neurons 3, PACSIN-3, Endophilin 1, Endophilin I, Endophilin-I, SH3 Domain-containing Protein 6511)
Product Gene Name
Product Synonym Names
Anti -PACSIN3 (Protein Kinase C and Casein Kinase Substrate in Neurons 3, PACSIN-3, Endophilin 1, Endophilin I, Endophilin-I, SH3 Domain-containing Protein 6511)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as a liquid in PBS, 0.05% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse Endophilin-A1. Species Crossreactivity: rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,487 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (47199073..47208010, complement). Location: 11p12-p11.12
OMIM
606513
3D Structure
ModBase 3D Structure for Q9UKS6
Immunogen
Linear peptide corresponding to mouse Endophilin-A1(KLH).
Positive Control
Mouse brain tissue lysate.
Applications Tested/Suitable for anti-PACSIN3 antibody
Western Blot (WB)
Application Notes for anti-PACSIN3 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:500

Western Blot (WB) of anti-PACSIN3 antibody

Western Blotting Analysis: Representative lot data. Mouse brain tissue lysate was probed with Anti-Endophilin-A1 (1:500 dilution). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and detected using a chemiluminescence detection system. Arrow indicates Endophilin-A1 (~42kD). Note: Film exposure time: 15 min.
Rabbit Anti-PACSIN3 Polyclonal Antibody – Cat# MBS625347

Western Blot (WB) of anti-PACSIN3 antibody

Western Blotting Analysis Representative lot data: Rat brain (lane 1) and mouse brain (lane 2) membrane tissue lysates were probed with Anti-Endophilin-A1 (1:500 dilution). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and detected using a chemiluminescence detection system. Arrow indicates Endophilin-A1 (~42kD). Note: Film exposure time: 15 min.
Rabbit Anti-PACSIN3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625347

Other Notes

Small volumes of anti-PACSIN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PACSIN3 purchase

MBS625347 is an antibody targeting PACSIN3. Also known as PACSIN3 (Protein Kinase C and Casein Kinase Substrate in Neurons 3, PACSIN-3, Endophilin 1, Endophilin I, Endophilin-I, SH3 Domain-containing Protein 6511). Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PACSIN3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein kinase C and casein kinase substrate in neurons protein 3
NCBI Official Synonym Full Names
protein kinase C and casein kinase substrate in neurons 3
NCBI Official Symbol
PACSIN3
NCBI Official Synonym Symbols
SDPIII; FLJ17861
UniProt Protein Name
Protein kinase C and casein kinase substrate in neurons protein 3
UniProt Synonym Protein Names
Endophilin I; SH3 domain-containing protein 6511
UniProt Gene Name
PACSIN3
UniProt Entry Name
PACN3_HUMAN
NCBI Protein Information
protein kinase C and casein kinase substrate in neurons protein 3; syndapin III; OTTHUMP00000234262; OTTHUMP00000234263; OTTHUMP00000234264; SH3 domain-containing protein 6511

NCBI Summary for PACSIN3

This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

UniProt Comments for PACSIN3

PACSIN3: May play a role in vesicle formation and transport. Belongs to the PACSIN family.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 11p12-p11.12

Cellular Component: nucleoplasm; membrane; cytoplasm; plasma membrane; endosome

Molecular Function: protein binding; cytoskeletal protein binding; phospholipid binding; calcium channel inhibitor activity; lipid binding

Biological Process: negative regulation of calcium ion transport; negative regulation of endocytosis; regulation of endocytosis; endocytosis; cytoskeleton organization and biogenesis; positive regulation of membrane protein ectodomain proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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