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RCC1-Like G Exchanging Factor (RCBTB2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625385

RCBTB2 is a member of the RCC1-related GEF family. The N-terminal half of the amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase… More details

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Product Overview

Online Datasheet in PDF
Product Name
RCC1-like G Exchanging Factor (RCBTB2), Polyclonal Antibody
Full Product Name
RCC1-like G Exchanging Factor, NT (RCC1 And BTB Domain-containing Protein 2, Regulator Of Chromosome Condensation And BTB Domain-containing Protein 2, Chromosome Condensation 1-like, CHC1-L, CHC1L, RLG, RCBTB2)
Product Gene Name
anti-RCBTB2 antibody
Product Synonym Names
Anti -RCC1-like G Exchanging Factor, NT (RCC1 And BTB Domain-containing Protein 2, Regulator Of Chromosome Condensation And BTB Domain-containing Protein 2, Chromosome Condensation 1-like, CHC1-L, CHC1L, RLG, RCBTB2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human CHC1L.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
60,315 Da
Chromosome Location
Chromosome: 13; NC_000013.10 (49063099..49107341, complement). Location: 13q14.3
OMIM
603524
3D Structure
ModBase 3D Structure for O95199
Immunogen
Synthetic peptide selected from the N-terminal region of human CHC1L (KLH).

Product Categories/Family for anti-RCBTB2 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-RCBTB2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-RCBTB2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-RCBTB2 antibody

Western blot analysis of CHC1L Antibody (N-term) in mouse thymus tissue lysates (35ug/lane). CHC1L (arrow) was detected using the purified Pab.
Rabbit Anti-RCBTB2 Polyclonal Antibody – Cat# MBS625385

Immunohistochemistry (IHC) of anti-RCBTB2 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with CHC1L Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-RCBTB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625385

Flow Cytometry (FC/FACS) of anti-RCBTB2 antibody

CHC1L Antibody (N-term) flow cytometric analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-RCBTB2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS625385

Other Notes

Small volumes of anti-RCBTB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RCBTB2 purchase

MBS625385 is an antibody targeting RCBTB2. Also known as RCC1-like G Exchanging Factor, NT (RCC1 And BTB Domain-containing Protein 2, Regulator Of Chromosome Condensation And BTB Domain-containing Protein 2, Chromosome Condensation 1-like, CHC1-L, CHC1L, RLG, RCBTB2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RCBTB2. It may not necessarily be applicable to this product.

NCBI GI #
4557445
NCBI GeneID
1102
NCBI Accession #
NP_001259.1
UniProt Primary Accession #
O95199
UniProt Secondary Accession #
B2RDW8
UniProt Related Accession #
O95199
GenBank Nucleotide #
NM_001268.2
NCBI Official Full Name
RCC1 and BTB domain-containing protein 2
NCBI Official Synonym Full Names
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
NCBI Official Symbol
RCBTB2
NCBI Official Synonym Symbols
CHC1L
UniProt Protein Name
RCC1 and BTB domain-containing protein 2
UniProt Synonym Protein Names
Chromosome condensation 1-like; CHC1-L; RCC1-like G exchanging factor; Regulator of chromosome condensation and BTB domain-containing protein 2
Protein Family
RCC1 and BTB domain-containing protein
UniProt Gene Name
RCBTB2
UniProt Synonym Gene Names
CHC1L; RLG; CHC1-L
UniProt Entry Name
RCBT2_HUMAN
NCBI Protein Information
RCC1 and BTB domain-containing protein 2; CHC1-L; RCC1-like G exchanging factor RLG; regulator of chromosome condensation and BTB domain containing protein 2; regulator of chromosome condensation and BTB domain-containing protein 2

NCBI Summary for RCBTB2

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. [provided by RefSeq, Jul 2008]
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UniProt Comments for RCBTB2

RCBTB2: 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 13q14.3

Molecular Function: Ran guanyl-nucleotide exchange factor activity

Research Articles on RCBTB2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RCBTB2 antibody

 Reference Product  PubMed Publications
 RCC1 antibody  >1 publications with RCBTB2 and RCC1

Diseases associated with anti-RCBTB2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with RCBTB2 and Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with RCBTB2 and Cardiovascular Diseases

Organs/Tissues associated with anti-RCBTB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with RCBTB2 and Blood
 Bone Antibodies  >1 publications with RCBTB2 and Bone
 Vascular Antibodies  >1 publications with RCBTB2 and Vascular
 Prostate Antibodies  >1 publications with RCBTB2 and Prostate
 Bone Marrow Antibodies  >1 publications with RCBTB2 and Bone Marrow
 Eye Antibodies  >1 publications with RCBTB2 and Eye
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