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TNK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625393

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TNK1, Polyclonal Antibody
Full Product Name
TNK1, ID (Non-receptor Tyrosine-protein Kinase TNK1, CD38 Negative Kinase 1)
Product Gene Name
anti-TNK1 antibody
Product Synonym Names
Anti -TNK1, ID (Non-receptor Tyrosine-protein Kinase TNK1, CD38 Negative Kinase 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human TNK1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
72,468 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (7284365..7293092). Location: 17p13.1
OMIM
608076
3D Structure
ModBase 3D Structure for Q13470
Immunogen
Synthetic peptide selected from the center region of human TNK1 (KLH).

Product Categories/Family for anti-TNK1 antibody

Antibodies; Abs to Tyrosine Kinases
Applications Tested/Suitable for anti-TNK1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TNK1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:250-1:500

Western Blot (WB) of anti-TNK1 antibody

Western blot analysis of anti-TNK1 pab (cat# AP7722c) in Hela cell line lysate. Dilution of anti-TNK1 was 1:100; dilution of secondary antibody (goat anti-rabbit-HRP) was 1:7000. Data and protocol courtesy of Dr. Richard Lu, Partners HealthCare System at Harvard University.
Rabbit Anti-TNK1 Polyclonal Antibody – Cat# MBS625393

Immunohistochemistry (IHC) of anti-TNK1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-TNK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625393

Other Notes

Small volumes of anti-TNK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNK1 purchase

MBS625393 is an antibody targeting TNK1. Also known as TNK1, ID (Non-receptor Tyrosine-protein Kinase TNK1, CD38 Negative Kinase 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNK1. It may not necessarily be applicable to this product.

NCBI GI #
23273502
NCBI GeneID
8711
UniProt Primary Accession #
Q13470
UniProt Secondary Accession #
O95364; Q8IYI4
UniProt Related Accession #
Q13470
NCBI Official Full Name
TNK1 protein
NCBI Official Synonym Full Names
tyrosine kinase, non-receptor, 1
NCBI Official Symbol
TNK1
NCBI Official Synonym Symbols
MGC46193
UniProt Protein Name
Non-receptor tyrosine-protein kinase TNK1
UniProt Synonym Protein Names
CD38 negative kinase 1
Protein Family
Non-receptor tyrosine-protein kinase
UniProt Gene Name
TNK1
UniProt Entry Name
TNK1_HUMAN
NCBI Protein Information
non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1

NCBI Summary for TNK1

TNK1 is a nonreceptor tyrosine kinase. These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.[supplied by OMIM]

UniProt Comments for TNK1

TNK1: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. Belongs to the protein kinase superfamily. Tyr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Ack family

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: extrinsic to internal side of plasma membrane; membrane; cytoplasm; cytosol

Molecular Function: protein binding; signal transducer activity; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; hormone receptor binding

Biological Process: cell migration; protein amino acid autophosphorylation; innate immune response; negative regulation of Ras protein signal transduction; negative regulation of cell growth; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
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Research Articles on TNK1

1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TNK1 antibody

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with anti-TNK1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with TNK1 and Nervous System Diseases
 Leukemia Antibodies  >2 publications with TNK1 and Leukemia
 Lung Neoplasms Antibodies  >1 publications with TNK1 and Lung Neoplasms
 Multiple Myeloma Antibodies  >1 publications with TNK1 and Multiple Myeloma
 Influenza, Human Antibodies  >1 publications with TNK1 and Influenza, Human

Organs/Tissues associated with anti-TNK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with TNK1 and Blood
 Embryonic Tissue Antibodies  >3 publications with TNK1 and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with TNK1 and Lymph Node
 Ovary Antibodies  >1 publications with TNK1 and Ovary
 Lung Antibodies  >1 publications with TNK1 and Lung
 Intestine Antibodies  >1 publications with TNK1 and Intestine
 Testis Antibodies  >1 publications with TNK1 and Testis
 Spleen Antibodies  >1 publications with TNK1 and Spleen
 Prostate Antibodies  >1 publications with TNK1 and Prostate
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