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PRDX3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625405

PRDX3 is a protein with antioxidant function and is localized in the mitochondrion. This protein is involved in redox regulation of the cell and Protects radical-sensitive enzymes from oxidative damage by a radical-generating system.It Acts synergistically… More details

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Product Overview

Online Datasheet in PDF
Product Name
PRDX3, Polyclonal Antibody
Full Product Name
PRDX3, NT (Thioredoxin-dependent Peroxide Reductase, Mitochondrial, Peroxiredoxin-3, Peroxiredoxin III, PRX III, Antioxidant Protein 1, AOP-1, Protein MER5 Homolog, HBC189, AOP1)
Product Gene Name
anti-PRDX3 antibody
Product Synonym Names
Anti -PRDX3, NT (Thioredoxin-dependent Peroxide Reductase, Mitochondrial, Peroxiredoxin-3, Peroxiredoxin III, PRX III, Antioxidant Protein 1, AOP-1, Protein MER5 Homolog, HBC189, AOP1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.115% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human PRDX3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
27,693 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (120927215..120938345, complement). Location: 10q25-q26
OMIM
604769
3D Structure
ModBase 3D Structure for P30048
Immunogen
Synthetic peptide selected from the N-terminal region of human PRDX3 (KLH).

Product Categories/Family for anti-PRDX3 antibody

Antibodies; Abs to Enzymes; Peroxiredoxin
Applications Tested/Suitable for anti-PRDX3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PRDX3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PRDX3 antibody

Western blot analysis of PRDX3 Antibody (N-term) in NCI-H460,MDA-MB231,HepG2 cell line lysates (35ug/lane). PRDX3 (arrow) was detected using the purified Pab.(2ug/ml)
Rabbit Anti-PRDX3 Polyclonal Antibody – Cat# MBS625405

Immunohistochemistry (IHC) of anti-PRDX3 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PRDX3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PRDX3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625405

Flow Cytometry (FC/FACS) of anti-PRDX3 antibody

Flow cytometric analysis of MDA-MB468 cells using PRDX3 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PRDX3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS625405

Western Blot (WB) of anti-PRDX3 antibody

Western blot analysis of PRDX3 (arrow) using rabbit polyclonal PRDX3 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PRDX3 gene.
Rabbit Anti-PRDX3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625405

Other Notes

Small volumes of anti-PRDX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX3 purchase

MBS625405 is an antibody targeting PRDX3. Also known as PRDX3, NT (Thioredoxin-dependent Peroxide Reductase, Mitochondrial, Peroxiredoxin-3, Peroxiredoxin III, PRX III, Antioxidant Protein 1, AOP-1, Protein MER5 Homolog, HBC189, AOP1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX3. It may not necessarily be applicable to this product.

NCBI GI #
47496635
NCBI GeneID
10935
UniProt Primary Accession #
P30048
UniProt Secondary Accession #
P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4; B2R7Z0; D3DRC9
UniProt Related Accession #
P30048; Q14579; Q53HC2; Q9UHU0
NCBI Official Full Name
PRDX3
NCBI Official Synonym Full Names
peroxiredoxin 3
NCBI Official Symbol
PRDX3
NCBI Official Synonym Symbols
AOP1; MER5; AOP-1; SP-22; PRO1748; MGC24293; MGC104387
UniProt Protein Name
Thioredoxin-dependent peroxide reductase, mitochondrial
UniProt Synonym Protein Names
Antioxidant protein 1; AOP-1; HBC189; Peroxiredoxin III; Prx-III; Peroxiredoxin-3; Protein MER5 homolog
Protein Family
Thioredoxin-dependent peroxide reductase
UniProt Gene Name
PRDX3
UniProt Synonym Gene Names
AOP1
UniProt Entry Name
PRDX3_HUMAN
NCBI Protein Information
thioredoxin-dependent peroxide reductase, mitochondrial; HBC189; prx-III; peroxiredoxin-3; peroxiredoxin III; OTTHUMP00000020590; protein MER5 homolog; antioxidant protein 1

NCBI Summary for PRDX3

This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for PRDX3

PRDX3: Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Belongs to the AhpC/TSA family.

Protein type: EC 1.11.1.15; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q25-q26

Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; early endosome; IkappaB kinase complex; cytosol

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; thioredoxin peroxidase activity; caspase inhibitor activity; alkyl hydroperoxide reductase activity; protein kinase binding; kinase binding

Biological Process: mitochondrion organization and biogenesis; negative regulation of kinase activity; response to lipopolysaccharide; negative regulation of caspase activity; activation of NF-kappaB transcription factor; response to reactive oxygen species; peptidyl-cysteine oxidation; regulation of mitochondrial membrane potential; response to hydrogen peroxide; hydrogen peroxide catabolic process; positive regulation of cell proliferation; myeloid cell differentiation; response to oxidative stress; maternal placenta development; negative regulation of apoptosis
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Research Articles on PRDX3

1. Paraneoplastic autoimmune reaction against retinal pigment epithelium, with PRDX3 as the putative antigen, may be a cause of acute exudative polymorphous vitelliform maculopathy (AEPVM).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRDX3 antibody

 Reference Product  PubMed Publications
 MAP3K13 antibody  >1 publications with PRDX3 and MAP3K13
 RPS6KC1 antibody  >1 publications with PRDX3 and RPS6KC1

Pathways associated with anti-PRDX3 antibody

 Products by Pathway  Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-PRDX3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >20 publications with PRDX3 and Neoplasms
 Drug Toxicity Antibodies  >7 publications with PRDX3 and Drug Toxicity
 Skin Diseases Antibodies  >7 publications with PRDX3 and Skin Diseases
 Breast Neoplasms Antibodies  >5 publications with PRDX3 and Breast Neoplasms
 Carcinoma Antibodies  >5 publications with PRDX3 and Carcinoma
 Leukemia Antibodies  >5 publications with PRDX3 and Leukemia
 Liver Diseases Antibodies  >5 publications with PRDX3 and Liver Diseases
 Genetic Diseases, Inborn Antibodies  >5 publications with PRDX3 and Genetic Diseases, Inborn
 Inflammation Antibodies  >5 publications with PRDX3 and Inflammation
 Nervous System Diseases Antibodies  >4 publications with PRDX3 and Nervous System Diseases

Organs/Tissues associated with anti-PRDX3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with PRDX3 and Blood
 Brain Antibodies  >9 publications with PRDX3 and Brain
 Liver Antibodies  >8 publications with PRDX3 and Liver
 Heart Antibodies  >8 publications with PRDX3 and Heart
 Muscle Antibodies  >7 publications with PRDX3 and Muscle
 Lung Antibodies  >7 publications with PRDX3 and Lung
 Eye Antibodies  >6 publications with PRDX3 and Eye
 Nerve Antibodies  >5 publications with PRDX3 and Nerve
 Vascular Antibodies  >4 publications with PRDX3 and Vascular
 Kidney Antibodies  >4 publications with PRDX3 and Kidney
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