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DUSP5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625457

DUSP5 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the… More details

$800 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DUSP5 Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3), Polyclonal Antibody
Full Product Name
DUSP5, NT Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3)
Product Gene Name
anti-DUSP5 antibody
Product Synonym Names
Anti -DUSP5, NT Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human DUSP5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,047 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (112257625..112271302). Location: 10q25
OMIM
603069
3D Structure
ModBase 3D Structure for Q16690
Immunogen
Synthetic peptide selected from the N-terminal region of human DUSP5 (KLH).

Product Categories/Family for anti-DUSP5 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-DUSP5 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DUSP5 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-DUSP5 antibody

Western Blot to detect DUSP5 in HL60 tissue lysate using MBS625457.
Rabbit Anti-DUSP5 Polyclonal Antibody – Cat# MBS625457

Immunohistochemistry (IHC) of anti-DUSP5 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human brain tissue reacted with MBS625457, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS625457 for immunohistochemistry.
Rabbit Anti-DUSP5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625457

Other Notes

Small volumes of anti-DUSP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP5 purchase

MBS625457 is an antibody targeting DUSP5. Also known as DUSP5, NT Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP5. It may not necessarily be applicable to this product.

NCBI GI #
62865890
NCBI GeneID
1847
NCBI Accession #
NP_004410.3
UniProt Primary Accession #
Q16690
UniProt Secondary Accession #
Q12997; Q5T603
UniProt Related Accession #
Q16690; Q59EI8
GenBank Nucleotide #
NM_004419.3
NCBI Official Full Name
dual specificity protein phosphatase 5
NCBI Official Synonym Full Names
dual specificity phosphatase 5
NCBI Official Symbol
DUSP5
NCBI Official Synonym Symbols
DUSP; HVH3
UniProt Protein Name
Dual specificity protein phosphatase 5
UniProt Synonym Protein Names
Dual specificity protein phosphatase hVH3
Protein Family
Dual specificity protein phosphatase
UniProt Gene Name
DUSP5
UniProt Synonym Gene Names
VH3
UniProt Entry Name
DUS5_HUMAN
NCBI Protein Information
dual specificity protein phosphatase 5; OTTHUMP00000020476; VH1-like phosphatase 3; dual specificity protein phosphatase hVH3; serine/threonine specific protein phosphatase

NCBI Summary for DUSP5

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq]
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UniProt Comments for DUSP5

DUSP5: a dual-specificity protein phosphatase containing one Rhodanese domain. Is a direct transcriptional target of p53. Targets include phosphorylated MAP kinases. Overexpression suppresses the growth of several types of human cancer cells. Induced by IL-2, IL-7, and IL-15 but not IL-4 in T cells.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleus

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: endoderm formation; protein amino acid dephosphorylation; inactivation of MAPK activity
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Research Articles on DUSP5

1. DUSP5 and DUSP6 selectively control ERK pathway activity and proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DUSP5 antibody

 Reference Product  PubMed Publications
 MAPK1 antibody  >11 publications with DUSP5 and MAPK1
 MAPK3 antibody  >1 publications with DUSP5 and MAPK3

Pathways associated with anti-DUSP5 antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-DUSP5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >12 publications with DUSP5 and Neoplasms
 Lymphoma Antibodies  >7 publications with DUSP5 and Lymphoma
 Death Antibodies  >6 publications with DUSP5 and Death
 Necrosis Antibodies  >4 publications with DUSP5 and Necrosis
 Autoimmune Diseases Antibodies  >4 publications with DUSP5 and Autoimmune Diseases
 Carcinoma Antibodies  >3 publications with DUSP5 and Carcinoma
 Lymphoma, B-Cell Antibodies  >3 publications with DUSP5 and Lymphoma, B-Cell
 Inflammation Antibodies  >2 publications with DUSP5 and Inflammation
 Breast Neoplasms Antibodies  >2 publications with DUSP5 and Breast Neoplasms
 Glioblastoma Antibodies  >2 publications with DUSP5 and Glioblastoma

Organs/Tissues associated with anti-DUSP5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with DUSP5 and Blood
 Kidney Antibodies  >4 publications with DUSP5 and Kidney
 Brain Antibodies  >4 publications with DUSP5 and Brain
 Liver Antibodies  >3 publications with DUSP5 and Liver
 Nerve Antibodies  >3 publications with DUSP5 and Nerve
 Embryonic Tissue Antibodies  >3 publications with DUSP5 and Embryonic Tissue
 Bone Antibodies  >2 publications with DUSP5 and Bone
 Spleen Antibodies  >2 publications with DUSP5 and Spleen
 Eye Antibodies  >2 publications with DUSP5 and Eye
 Bone Marrow Antibodies  >2 publications with DUSP5 and Bone Marrow
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