NKp46 Antibody – Mouse Monoclonal

MBS6255181 is an antibody targeting NKp46. Also known as NKp46, Natural Cytotoxicity Receptor (NCR NKp46, CD335, Lymphocyte Antigen 94, Ly94, Natural Cytotoxicity Triggering Receptor 1, NCR1, NCT1, Natural Killer Cell Activating Receptor NKp46, NK Cell Activating Receptor) (MaxLight 550). Reactive in Bovine. Host: Mouse.

1. Storset, A.K. et al. (2004) NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. Eur J Immunol. 34 (3): 669-76. 2. Kulberg, S. et al. (2004) Reference values for relative numbers of natural killer cells in cattle blood. Dev Comp Immunol. 28 (9): 941-8. 3. Van Rhijn, I. et al. (2007) Massive, sustained gamma/delta T cell migration from the bovine skin in vivo. J Leukoc Biol. 81: 968-73. 4. Toka, F.N. et al. (2011) Rapid and Transient Activation of gamma/delta T Cells to IFN-gamma Production, NK Cell-Like Killing, and Antigen Processing during Acute Virus Infection. J Immunol. 186: 4853-61. 5. Bastos, R.G. et al. (2008) Bovine NK cells acquire cytotoxic activity and produce IFN-gamma after stimulation by Mycobacterium bovis BCG- or Babesia bovis-exposed splenic dendritic cells. Vet Immunol Immunopathol. 124: 302-12. 6. Boysen, P. et al. (2006) Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation status. BMC Immunol. 7:10. 7. Elhmouzi-Younes, J. et al. (2009) Bovine neonate natural killer cells are fully functional and highly responsive to interleukin-15 and to NKp46 receptor stimulation. Vet Res. 40: 54. 8. Elhmouzi-Younes, J. et al. (2010) Ovine CD16+/CD14- blood lymphocytes present all the major characteristics of natural killer cells. Vet Res. 41:4. 9. Hoek, A. et al. (2009) Subpopulations of bovine WC1(+) gamma/delta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo. Vet Res. 40:6. 10. Zuerner, R.L. et al. (2011) A Leptospira borgpetersenii Serovar Hardjo Vaccine Induces a Th1 Response, Activates NK Cells, and Reduces Renal Colonization. Clin Vaccine Immunol. 18: 684-91. 11. Nelson, D.D. et al. (2010) CD8(+)/perforin(+)/WC1(-) gamma/delta T cells, not CD8(+) alpha/beta T cells, infiltrate vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Vet Immunol Immunopathol. 136: 284-91. 12. Banos, G. et al. (2013) Identification of immune traits correlated with dairy cow health, reproduction and productivity. PLoS One. 8: e65766. 13. Ramstead, A.G. et al. (2015) Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B. Int Immunopharmacol. 26 (2): 367-77. 14. Boysen, P. et al. (2008) Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties. Dev Comp Immunol. 32 (7): 773-83. 15. Gonzalez-Cano, P. et al. (2014) Two functionally distinct myeloid dendritic cell subpopulations are present in bovine blood. Dev Comp Immunol. 44 (2): 378-88. 16. Di Palma, S. et al. (2012) Comparative spatiotemporal analysis of the intrathecal immune response in natural listeric rhombencephalitis of cattle and small ruminants. Comp Immunol Microbiol Infect Dis. 35 (5): 429-41. 17. Pirson, C. et al. (2015) Highly purified mycobacterial phosphatidylinositol mannosides drive cell-mediated responses and activate NKT cells in cattle. Clin Vaccine Immunol. 22 (2): 178-84. 18. Schneider, D.A. et al. (2011) Dynamics of bovine spleen cell populations during the acute response to Babesia bovis infection: an immunohistological study. Parasite Immunol. 33 (1): 34-44. 19. Van Meulder F et al. (2015) Analysis of the protective immune response following intramuscular vaccination of calves against the intestinal parasite Cooperia oncophora. Int J Parasitol. 45 (9-10): 637-46. 20. Patch, J.R. et al. (2014) Infection with foot-and-mouth disease virus (FMDV) induces a natural killer (NK) cell response in cattle that is lacking following vaccination. Comp Immunol Microbiol Infect Dis. 37 (4): 249-57. 21. Hedges, J.F. et al. (2015) Amphotericin B stimulates gamma delta T and NK cells, and enhances protection from Salmonella infection. Innate Immun. pii: 1753425914567692. 22. Allan AJ et al. (2015) Cattle NK Cell Heterogeneity and the Influence of MHC Class I. J Immunol. pii: 1500227. 1. Sivori, S. et al. (1997) p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J Exp Med. 186 (7): 1129-36. 2. Storset, A.K. et al. (2003) Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. Eur J Immunol. 33 (4): 980-90.

Small volumes of anti-NKp46 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.