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IRF8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625546

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IRF8, Polyclonal Antibody
Full Product Name
IRF8, CT (Interferon Regulatory Factor 8, IRF-8, Interferon Consensus Sequence-binding Protein, ICSBP, IRF8, ICSBP1)
Product Gene Name
anti-IRF8 antibody
Product Synonym Names
Anti -IRF8, CT (Interferon Regulatory Factor 8, IRF-8, Interferon Consensus Sequence-binding Protein, ICSBP, IRF8, ICSBP1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human IRF8.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,356 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (85932774..85956212). Location: 16q24.1
OMIM
601565
3D Structure
ModBase 3D Structure for Q02556
Immunogen
Synthetic peptide selected from the C-terminal region of human IRF8 (KLH).

Product Categories/Family for anti-IRF8 antibody

Antibodies; Abs to Interferon
Applications Tested/Suitable for anti-IRF8 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-IRF8 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-IRF8 antibody

Western blot analysis of anti-IRF8 Antibody (C-term) in HL60 cell line lysates (35ug/lane). IRF8 (arrow) was detected using the purified Pab.
Rabbit Anti-IRF8 Polyclonal Antibody – Cat# MBS625546

Flow Cytometry (FC/FACS) of anti-IRF8 antibody

IRF8 Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-IRF8 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS625546

Other Notes

Small volumes of anti-IRF8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF8 purchase

MBS625546 is an antibody targeting IRF8. Also known as IRF8, CT (Interferon Regulatory Factor 8, IRF-8, Interferon Consensus Sequence-binding Protein, ICSBP, IRF8, ICSBP1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF8. It may not necessarily be applicable to this product.

NCBI GI #
4504567
NCBI GeneID
3394
NCBI Accession #
NP_002154.1
UniProt Primary Accession #
Q02556
UniProt Secondary Accession #
A0AV82
UniProt Related Accession #
Q02556
GenBank Nucleotide #
NM_002163.2
NCBI Official Full Name
interferon regulatory factor 8
NCBI Official Synonym Full Names
interferon regulatory factor 8
NCBI Official Symbol
IRF8
NCBI Official Synonym Symbols
ICSBP; IRF-8; ICSBP1; H-ICSBP
UniProt Protein Name
Interferon regulatory factor 8
UniProt Synonym Protein Names
Interferon consensus sequence-binding protein
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF8
UniProt Synonym Gene Names
ICSBP1
UniProt Entry Name
IRF8_HUMAN
NCBI Protein Information
interferon regulatory factor 8; OTTHUMP00000175003; interferon consensus sequence binding protein 1

UniProt Comments for IRF8

IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding

Biological Process: transcription from RNA polymerase II promoter; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; defense response to bacterium; myeloid cell differentiation; immune response; negative regulation of transcription from RNA polymerase II promoter; defense response to protozoan; phagocytosis

Disease: Monocyte And Dendritic Cell Deficiency, Autosomal Recessive; Immunodeficiency 32a
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Research Articles on IRF8

1. We detected two distinct disease-causing mutations affecting interferon regulatory factor 8 (IRF8). Both mutations impair IRF8 transcriptional activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRF8 antibody

 Reference Product  PubMed Publications
 IRF1 antibody  >12 publications with IRF8 and IRF1
 IRF2 antibody  >5 publications with IRF8 and IRF2
 SPI1 antibody  >3 publications with IRF8 and SPI1
 TRAF6 antibody  >1 publications with IRF8 and TRAF6

Pathways associated with anti-IRF8 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Type II Interferon Signaling (IFNG) Pathway antibodies  Type II Interferon Signaling (IFNG) Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram

Diseases associated with anti-IRF8 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >28 publications with IRF8 and Neoplasms
 Leukemia Antibodies  >26 publications with IRF8 and Leukemia
 Leukemia, Myeloid Antibodies  >18 publications with IRF8 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >10 publications with IRF8 and Leukemia, Myeloid, Acute
 Inflammation Antibodies  >8 publications with IRF8 and Inflammation
 Multiple Sclerosis Antibodies  >7 publications with IRF8 and Multiple Sclerosis
 Lymphoma Antibodies  >5 publications with IRF8 and Lymphoma
 Lymphoma, Non-Hodgkin Antibodies  >4 publications with IRF8 and Lymphoma, Non-Hodgkin
 Bacterial Infections Antibodies  >4 publications with IRF8 and Bacterial Infections
 Intestinal Diseases Antibodies  >3 publications with IRF8 and Intestinal Diseases

Organs/Tissues associated with anti-IRF8 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >38 publications with IRF8 and Blood
 Spleen Antibodies  >7 publications with IRF8 and Spleen
 Lymph Node Antibodies  >7 publications with IRF8 and Lymph Node
 Tonsil Antibodies  >4 publications with IRF8 and Tonsil
 Pharynx Antibodies  >4 publications with IRF8 and Pharynx
 Lung Antibodies  >4 publications with IRF8 and Lung
 Stomach Antibodies  >1 publications with IRF8 and Stomach
 Embryonic Tissue Antibodies  >1 publications with IRF8 and Embryonic Tissue
 Intestine Antibodies  >1 publications with IRF8 and Intestine
 Muscle Antibodies  >1 publications with IRF8 and Muscle
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