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PDIA6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625608

Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded… More details

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Product Overview

Online Datasheet in PDF
Product Name
PDIA6, Polyclonal Antibody
Full Product Name
PDIA6, ID (K159) (Protein Disulfide-isomerase A6, Protein Disulfide Isomerase P5, Thioredoxin Domain-containing Protein 7, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, TXNDC7, PDIA6)
Product Gene Name
anti-PDIA6 antibody
Product Synonym Names
Anti -PDIA6, ID (K159) (Protein Disulfide-isomerase A6, Protein Disulfide Isomerase P5, Thioredoxin Domain-containing Protein 7, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, TXNDC7, PDIA6)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human PDIA6. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,121 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (10923517..10952960, complement). Location: 2p25.1
OMIM
611099
3D Structure
ModBase 3D Structure for Q15084
Immunogen
Synthetic peptide selected from the Center region of human PDIA6 (KLH).

Product Categories/Family for anti-PDIA6 antibody

Antibodies; Abs to Enzymes; Isomerase
Applications Tested/Suitable for anti-PDIA6 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PDIA6 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PDIA6 antibody

Western blot analysis of PDIA6 antibody (Center K159) in Y79 cell line lysates (35ug/lane). PDIA6 (arrow) was detected using the purified Pab.
Rabbit Anti-PDIA6 Polyclonal Antibody – Cat# MBS625608

Western Blot (WB) of anti-PDIA6 antibody

Western blot analysis of PDIA6 antibody (Center K159) in mouse stomach tissue lysates (35ug/lane). PDIA6 (arrow) was detected using the purified Pab.
Rabbit Anti-PDIA6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625608

Immunohistochemistry (IHC) of anti-PDIA6 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with PDIA6 Antibody (Center K159), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PDIA6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625608

Flow Cytometry (FC/FACS) of anti-PDIA6 antibody

Flow cytometric analysis of hela cells using PDIA6 Antibody (Center K159)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PDIA6 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS625608

Other Notes

Small volumes of anti-PDIA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDIA6 purchase

MBS625608 is an antibody targeting PDIA6. Also known as PDIA6, ID (K159) (Protein Disulfide-isomerase A6, Protein Disulfide Isomerase P5, Thioredoxin Domain-containing Protein 7, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, TXNDC7, PDIA6). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDIA6. It may not necessarily be applicable to this product.

NCBI GI #
119621355
NCBI GeneID
10130
UniProt Primary Accession #
Q15084
UniProt Secondary Accession #
Q6ZSH5; Q99778
UniProt Related Accession #
Q15084; Q53RC7
NCBI Official Full Name
protein disulfide isomerase family A, member 6, isoform CRA_b
NCBI Official Synonym Full Names
protein disulfide isomerase family A, member 6
NCBI Official Symbol
PDIA6
NCBI Official Synonym Symbols
P5; ERP5; TXNDC7
UniProt Protein Name
Protein disulfide-isomerase A6
UniProt Synonym Protein Names
Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7
Protein Family
Protein disulfide-isomerase
UniProt Gene Name
PDIA6
UniProt Synonym Gene Names
ERP5; P5; TXNDC7
UniProt Entry Name
PDIA6_HUMAN
NCBI Protein Information
protein disulfide-isomerase A6; ER protein 5; OTTHUMP00000115548; OTTHUMP00000200409; OTTHUMP00000200410; protein disulfide isomerase P5; endoplasmic reticulum protein 5; thioredoxin domain-containing protein 7; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; thioredoxin domain containing 7 (protein disulfide isomerase)

NCBI Summary for PDIA6

Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM]
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UniProt Comments for PDIA6

PDIA6: May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 5.3.4.1; Isomerase

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; endoplasmic reticulum; melanosome; plasma membrane; ER-Golgi intermediate compartment

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; unfolded protein response; cell redox homeostasis; apoptotic cell clearance
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Research Articles on PDIA6

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDIA6 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram

Diseases associated with anti-PDIA6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with PDIA6 and Neoplasms
 Neuroectodermal Tumors Antibodies  >2 publications with PDIA6 and Neuroectodermal Tumors
 Melanoma Antibodies  >1 publications with PDIA6 and Melanoma
 Urologic Neoplasms Antibodies  >1 publications with PDIA6 and Urologic Neoplasms
 Adenocarcinoma Antibodies  >1 publications with PDIA6 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >1 publications with PDIA6 and Carcinoma, Squamous Cell
 Inflammation Antibodies  >1 publications with PDIA6 and Inflammation
 Anoxia Antibodies  >1 publications with PDIA6 and Anoxia
 Kidney Neoplasms Antibodies  >1 publications with PDIA6 and Kidney Neoplasms
 Breast Neoplasms Antibodies  >1 publications with PDIA6 and Breast Neoplasms

Organs/Tissues associated with anti-PDIA6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with PDIA6 and Blood
 Lung Antibodies  >2 publications with PDIA6 and Lung
 Bone Marrow Antibodies  >1 publications with PDIA6 and Bone Marrow
 Cervix Antibodies  >1 publications with PDIA6 and Cervix
 Bone Antibodies  >1 publications with PDIA6 and Bone
 Vascular Antibodies  >1 publications with PDIA6 and Vascular
 Kidney Antibodies  >1 publications with PDIA6 and Kidney
 Pancreas Antibodies  >1 publications with PDIA6 and Pancreas
 Liver Antibodies  >1 publications with PDIA6 and Liver
 Brain Antibodies  >1 publications with PDIA6 and Brain
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