• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

BMP10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625635

BMP10 is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bmp10, Polyclonal Antibody
Full Product Name
Bmp10, NT (Bone Morphogenetic Protein 10, BMP-10)
Product Gene Name
anti-BMP10 antibody
Product Synonym Names
Anti -Bmp10, NT (Bone Morphogenetic Protein 10, BMP-10)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Bmp10.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,047 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (69092613..69098649, complement). Location: 2p13.3
OMIM
608748
3D Structure
ModBase 3D Structure for O95393
Immunogen
Synthetic peptide selected from the N-terminal region of human Bmp10 (KLH).

Product Categories/Family for anti-BMP10 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-BMP10 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-BMP10 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:200
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-BMP10 antibody

Western Blot analysis in 293 cell line lysates (35ug/lane) using MBS625635. Bmp10(arrow) was detected using MBS625635.
Rabbit Anti-BMP10 Polyclonal Antibody – Cat# MBS625635

Immunohistochemistry (IHC) of anti-BMP10 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human cancer tissue reacted with MBS625635, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS625635 for immunohistochemistry. BC = breast carcinoma
Rabbit Anti-BMP10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625635

Other Notes

Small volumes of anti-BMP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP10 purchase

MBS625635 is an antibody targeting BMP10. Also known as Bmp10, NT (Bone Morphogenetic Protein 10, BMP-10). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP10. It may not necessarily be applicable to this product.

NCBI GI #
7656928
NCBI GeneID
27302
NCBI Accession #
NP_055297.1
UniProt Primary Accession #
O95393
UniProt Secondary Accession #
Q53R17; Q6NTE0
UniProt Related Accession #
O95393
GenBank Nucleotide #
NM_014482.1
NCBI Official Full Name
bone morphogenetic protein 10 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 10
NCBI Official Symbol
BMP10
NCBI Official Synonym Symbols
MGC126783
UniProt Protein Name
Bone morphogenetic protein 10
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP10
UniProt Entry Name
BMP10_HUMAN
NCBI Protein Information
bone morphogenetic protein 10; BMP-10; OTTHUMP00000159973

NCBI Summary for BMP10

The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq]

UniProt Comments for BMP10

BMP10: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: extracellular space; cell surface; cytoplasm; extracellular region; Z disc

Molecular Function: receptor serine/threonine kinase binding; protein binding; telethonin binding; growth factor activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: adult heart development; extracellular matrix organization and biogenesis; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell development; activin receptor signaling pathway; cardiac muscle cell proliferation; sarcomere organization; BMP signaling pathway; regulation of apoptosis; regulation of MAPKKK cascade; ventricular cardiac muscle morphogenesis; negative regulation of cell growth; cell adhesion; negative regulation of cell migration; positive regulation of cardiac muscle cell proliferation
Show more

Research Articles on BMP10

1. Bone morphogenetic protein-10 (BMP-10) may function as a tumor suppressor in breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-BMP10 antibody

 Products by Pathway  Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram

Diseases associated with anti-BMP10 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >5 publications with BMP10 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >3 publications with BMP10 and Heart Defects, Congenital
 Bone Diseases, Developmental Antibodies  >3 publications with BMP10 and Bone Diseases, Developmental
 Cardiomegaly Antibodies  >2 publications with BMP10 and Cardiomegaly
 Vascular Malformations Antibodies  >2 publications with BMP10 and Vascular Malformations
 Breast Neoplasms Antibodies  >1 publications with BMP10 and Breast Neoplasms
 Hypertension Antibodies  >1 publications with BMP10 and Hypertension
 Neoplasm Metastasis Antibodies  >1 publications with BMP10 and Neoplasm Metastasis
 Fibrosis Antibodies  >1 publications with BMP10 and Fibrosis
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000