Mouse Anti-ACTA2 Monoclonal Antibody – Cat# MBS6256433

Actin, Alpha (ACTA2) Antibody – Mouse Monoclonal

Name: ACTA2 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS6256433
Price: 905 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6256433

MBS6256433 is an antibody targeting ACTA2. Also known as Actin, alpha (MaxLight 750). Reactive in Human, Mouse, Porcine, Rabbit, Rat. Host: Mouse. More details

$905 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Actin, alpha (ACTA2), Monoclonal Antibody

Full Product Name

Actin, alpha (MaxLight 750)

Product Gene Name

anti-ACTA2 antibody

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

1A4

Host

Mouse

Species Reactivity

Human, Mouse, Porcine, Rabbit, Rat

Form/Format

Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight750.

Purity/Purification

Purified

Specificity

Recognizes human Actin alpha. Species Crossreactivity: Mouse, porcine, rabbit, rat.

Preparation and Storage

Store at 4 degree C. Do Not Freeze.

Molecular Weight

42,009 Da

OMIM

102620

3D Structure

ModBase 3D Structure for P62736

Immunogen

Acetylated N-terminal synthetic decapeptide of alpha smooth muscle actin coupled to KLH.

Conjugate

MaxLight750

Product Categories/Family for anti-ACTA2 antibody

Antibodies; Actin Related Proteins

Applications Tested/Suitable for anti-ACTA2 antibody

FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Product References and Citations for anti-ACTA2 antibody

1. Skalli, O. et al. (1986) A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J. Cell Biol. 103: 2787-96 2. Darby, I. et al. (1990) Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest. 63: 21-29 3. Desmoulière, A. et al. (1993) Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 122: 103-111 4. Hinz, B. et al. (2001) Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol. Biol. Cell. 12: 2730-27415. Hinz, B. et al. (2002) The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. J. Cell Biol. 157:657-663 6. Shin, M.O. et al. (2010) Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats. Nutr Res Pract. 4: 369-74. 7. Brisset, A.C. et al. (2007) Intimal smooth muscle cells of porcine and human coronary artery express S100A4, a marker of the rhomboid phenotype in vitro. Circ Res. 100: 1055-62.

Other Notes

Small volumes of anti-ACTA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACTA2. It may not necessarily be applicable to this product.

NCBI GI #

119570540

NCBI GeneID

NCBI Accession #

EAW50155.1

UniProt Primary Accession #

P62736

UniProt Secondary Accession #

P03996; P04108; Q6FI19; B2R8A4

UniProt Related Accession #

P62736

NCBI Official Full Name

actin, alpha 2, smooth muscle, aorta, isoform CRA_a

NCBI Official Synonym Full Names

actin, alpha 2, smooth muscle, aorta

NCBI Official Symbol

ACTA2

NCBI Official Synonym Symbols

AAT6; ACTSA; MYMY5

UniProt Protein Name

Actin, aortic smooth muscle

UniProt Synonym Protein Names

Alpha-actin-2; Cell growth-inhibiting gene 46 protein

Protein Family

Actin

UniProt Gene Name

ACTA2

UniProt Synonym Gene Names

ACTSA; ACTVS

UniProt Entry Name

ACTA_HUMAN

NCBI Protein Information

actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein

NCBI Summary for ACTA2

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

UniProt Comments for ACTA2

ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.

Protein type: Contractile; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: protein kinase binding; ATP binding

Biological Process: muscle contraction; regulation of blood pressure; response to virus; vascular smooth muscle contraction

Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6

Research Articles on ACTA2

1. Suggest dynamic interplay between transcriptional activators Pur-alpha/Pur-beta and repressors in regulating SMalphaA gene output during myofibroblast differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACTA2 antibody

Reference Product	PubMed Publications
TGFB1 antibody	>141 publications with ACTA2 and TGFB1
MYH11 antibody	>26 publications with ACTA2 and MYH11
TAGLN antibody	>10 publications with ACTA2 and TAGLN
CFL1 antibody	>1 publications with ACTA2 and CFL1
UBC antibody	>1 publications with ACTA2 and UBC
ACTN2 antibody	>1 publications with ACTA2 and ACTN2

Pathways associated with anti-ACTA2 antibody

Products by Pathway	Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
Smooth Muscle Contraction Pathway antibodies	Smooth Muscle Contraction Pathway Diagram
Striated Muscle Contraction Pathway antibodies	Striated Muscle Contraction Pathway Diagram
Vascular Smooth Muscle Contraction Pathway antibodies	Vascular Smooth Muscle Contraction Pathway Diagram
Vascular Smooth Muscle Contraction Pathway antibodies	Vascular Smooth Muscle Contraction Pathway Diagram

Diseases associated with anti-ACTA2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>222 publications with ACTA2 and Neoplasms
Fibrosis Antibodies	>217 publications with ACTA2 and Fibrosis
Inflammation Antibodies	>66 publications with ACTA2 and Inflammation
Liver Diseases Antibodies	>65 publications with ACTA2 and Liver Diseases
Disease Models, Animal Antibodies	>57 publications with ACTA2 and Disease Models, Animal
Liver Cirrhosis Antibodies	>48 publications with ACTA2 and Liver Cirrhosis
Kidney Diseases Antibodies	>41 publications with ACTA2 and Kidney Diseases
Breast Neoplasms Antibodies	>33 publications with ACTA2 and Breast Neoplasms
Aortic Aneurysm, Thoracic Antibodies	>29 publications with ACTA2 and Aortic Aneurysm, Thoracic
Heart Diseases Antibodies	>27 publications with ACTA2 and Heart Diseases

Organs/Tissues associated with anti-ACTA2 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>569 publications with ACTA2 and Muscle
Vascular Antibodies	>173 publications with ACTA2 and Vascular
Blood Antibodies	>126 publications with ACTA2 and Blood
Eye Antibodies	>99 publications with ACTA2 and Eye
Lung Antibodies	>99 publications with ACTA2 and Lung
Connective Tissue Antibodies	>89 publications with ACTA2 and Connective Tissue
Liver Antibodies	>85 publications with ACTA2 and Liver
Kidney Antibodies	>71 publications with ACTA2 and Kidney
Skin Antibodies	>63 publications with ACTA2 and Skin
Embryonic Tissue Antibodies	>47 publications with ACTA2 and Embryonic Tissue