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CD106 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6256507

MBS6256507 is an antibody targeting CD106. Also known as CD106 (CD106 Antigen, DKFZp779G2333, INCAM 100, INCAM-100, L1CAM, MGC99561, Vascular Cell Adhesion Molecule 1, VCAM 1, VCAM1, VCAM-1, Vascular Cell Adhesion Protein 1) (MaxLight 750). Reactive in Mouse.… More details

$905 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD106, Monoclonal Antibody
Full Product Name
CD106 (CD106 Antigen, DKFZp779G2333, INCAM 100, INCAM-100, L1CAM, MGC99561, Vascular Cell Adhesion Molecule 1, VCAM 1, VCAM1, VCAM-1, Vascular Cell Adhesion Protein 1) (MaxLight 750)
Product Gene Name
anti-CD106 antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
MVCAM A (429)
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight750.
Purity/Purification
Purified by protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes mouse VCAM-1. Reported to partially block VCAM-1 mediated functions (ref1).
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
38,372 Da
3D Structure
ModBase 3D Structure for P29533
Immunogen
Stromal cell line PA6.
Conjugate
MaxLight750

Product Categories/Family for anti-CD106 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-CD106 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

Product References and Citations for anti-CD106 antibody

1. Kinashi, T. and Springer, T.A. (1994) 20:25-44. 2. Wormley, F.L. et al. (2001) Infect. Immun. 69:5072-5079. 3. Woo, J.M. et al. (2010) Arthritis Res Ther. 12(3):R93. 4. Hall, L.J. et al. (2010) P J Immune Based Ther Vaccines. 8: 5. 5. Winnik, S. et al. (2011) Eur Heart J. Feb 9. 6. Hamada, T. et al. (2009) Am J Pathol. 174: 2265-77. 7. Hamada, T. et al. (2008) Hepatology. 47: 186-98. 8. Baumer, Y. et al. (2011) Exp Biol Med (Maywood). 236: 692-700. 9. Lau,. H.Y. and Bhatia, M. (2007) Am J Physiol Gastrointest Liver Physiol. 292: G1283-92.

Other Notes

Small volumes of anti-CD106 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD106. It may not necessarily be applicable to this product.

NCBI GI #
170295823
NCBI GeneID
22329
NCBI Accession #
NP_035823.3
UniProt Primary Accession #
P29533
UniProt Related Accession #
P29533
GenBank Nucleotide #
NM_011693.3
NCBI Official Full Name
vascular cell adhesion protein 1
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Official Symbol
Vcam1
NCBI Official Synonym Symbols
CD106; Vcam-1
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Synonym Protein Names
CD_antigen: CD106
Protein Family
Vascular cell adhesion protein
UniProt Gene Name
Vcam1
UniProt Synonym Gene Names
Vcam-1; V-CAM 1; VCAM-1
UniProt Entry Name
VCAM1_MOUSE
NCBI Protein Information
vascular cell adhesion protein 1

UniProt Comments for CD106

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: apical part of cell; cell surface; early endosome; endoplasmic reticulum; external side of plasma membrane; extracellular space; filopodium; Golgi apparatus; microvillus; podosome; sarcolemma

Molecular Function: amine oxidase activity; cell adhesion molecule binding; integrin binding

Biological Process: amine metabolic process; cell adhesion; cell-matrix adhesion; heart development; heterophilic cell adhesion; leukocyte adhesion; leukocyte tethering or rolling; positive regulation of T cell proliferation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD106 antibody

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD106 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >118 publications with CD106 and Inflammation
 Cardiovascular Diseases Antibodies  >76 publications with CD106 and Cardiovascular Diseases
 Necrosis Antibodies  >59 publications with CD106 and Necrosis
 Atherosclerosis Antibodies  >56 publications with CD106 and Atherosclerosis
 Heart Diseases Antibodies  >20 publications with CD106 and Heart Diseases
 Kidney Diseases Antibodies  >19 publications with CD106 and Kidney Diseases
 Fibrosis Antibodies  >14 publications with CD106 and Fibrosis
 Lung Diseases Antibodies  >13 publications with CD106 and Lung Diseases
 Hypertension Antibodies  >13 publications with CD106 and Hypertension
 Myocardial Ischemia Antibodies  >10 publications with CD106 and Myocardial Ischemia

Organs/Tissues associated with anti-CD106 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >27 publications with CD106 and Kidney
 Spleen Antibodies  >6 publications with CD106 and Spleen
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