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DOK5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625686

DOK5 is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase… More details

$895 / 0.2 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DOK5, Polyclonal Antibody
Full Product Name
DOK5, CT (Docking Protein 5, Downstream Of Tyrosine Kinase 5, Insulin Receptor Substrate 6, IRS-6, IRS6, C20orf180)
Product Gene Name
anti-DOK5 antibody
Product Synonym Names
Anti -DOK5, CT (Docking Protein 5, Downstream Of Tyrosine Kinase 5, Insulin Receptor Substrate 6, IRS-6, IRS6, C20orf180)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human DOK5. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,464 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (53092266..53267710). Location: 20q13.2
OMIM
608334
3D Structure
ModBase 3D Structure for Q9P104
Immunogen
Synthetic peptide selected from the C-terminal region of human DOK5 (KLH).

Product Categories/Family for anti-DOK5 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-DOK5 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DOK5 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-DOK5 antibody

The anti-DOK5 C-term Pab is used in Western blot to detect DOK5 in mouse liver tissue lysate.
Rabbit Anti-DOK5 Polyclonal Antibody – Cat# MBS625686

Immunohistochemistry (IHC) of anti-DOK5 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-DOK5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625686

Western Blot (WB) of anti-DOK5 antibody

Western blot analysis of DOK5 (arrow) using rabbit polyclonal DOK5 Antibody (L291) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DOK5 gene.
Rabbit Anti-DOK5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625686

Other Notes

Small volumes of anti-DOK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DOK5 purchase

MBS625686 is an antibody targeting DOK5. Also known as DOK5, CT (Docking Protein 5, Downstream Of Tyrosine Kinase 5, Insulin Receptor Substrate 6, IRS-6, IRS6, C20orf180). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK5. It may not necessarily be applicable to this product.

NCBI GI #
29544726
NCBI GeneID
55816
NCBI Accession #
NP_060901.2
UniProt Primary Accession #
Q9P104
UniProt Secondary Accession #
Q5T7Y0; Q5TE53; Q8TEW7; Q96H13; Q9BZ24; Q9NQF4; Q9Y411
UniProt Related Accession #
Q9P104
GenBank Nucleotide #
NM_018431.3
NCBI Official Full Name
docking protein 5
NCBI Official Synonym Full Names
docking protein 5
NCBI Official Symbol
DOK5
NCBI Official Synonym Symbols
MGC16926; C20orf180
UniProt Protein Name
Docking protein 5
UniProt Synonym Protein Names
Downstream of tyrosine kinase 5; Insulin receptor substrate 6
Protein Family
Docking protein
UniProt Gene Name
DOK5
UniProt Synonym Gene Names
C20orf180
UniProt Entry Name
DOK5_HUMAN
NCBI Protein Information
docking protein 5; IRS6; IRS-6; OTTHUMP00000031322; insulin receptor substrate 6; downstream of tyrosine kinase 5

NCBI Summary for DOK5

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq]
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UniProt Comments for DOK5

DOK5: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret in neuronal differentiation. Interacts with phosphorylated Ret. In contrast to other DOK proteins, it does not interact with RASGAP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.2

Molecular Function: receptor signaling protein activity; insulin receptor binding

Biological Process: nervous system development; MAPKKK cascade; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on DOK5

1. Although preliminary, these data suggest that DOK5 and perhaps several other genes influence the magnitude of amygdala activation during face processing, particularly in those with BD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DOK5 antibody

 Reference Product  PubMed Publications
 RET antibody  >2 publications with DOK5 and RET
 NTRK3 antibody  >1 publications with DOK5 and NTRK3
 NTRK2 antibody  >1 publications with DOK5 and NTRK2

Pathways associated with anti-DOK5 antibody

 Products by Pathway  Pathway Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram

Diseases associated with anti-DOK5 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >1 publications with DOK5 and Lung Neoplasms
 Adenocarcinoma Antibodies  >1 publications with DOK5 and Adenocarcinoma
 Carcinoma, Small Cell Antibodies  >1 publications with DOK5 and Carcinoma, Small Cell
 Paraganglioma Antibodies  >1 publications with DOK5 and Paraganglioma

Organs/Tissues associated with anti-DOK5 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with DOK5 and Muscle
 Brain Antibodies  >2 publications with DOK5 and Brain
 Bone Antibodies  >1 publications with DOK5 and Bone
 Heart Antibodies  >1 publications with DOK5 and Heart
 Lung Antibodies  >1 publications with DOK5 and Lung
 Embryonic Tissue Antibodies  >1 publications with DOK5 and Embryonic Tissue
 Kidney Antibodies  >1 publications with DOK5 and Kidney
 Ovary Antibodies  >1 publications with DOK5 and Ovary
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