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UBE2G1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625692

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s,… More details

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Product Overview

Online Datasheet in PDF
Product Name
UBE2G1, Polyclonal Antibody
Full Product Name
UBE2G1, NT (Ubiquitin-conjugating Enzyme E2 G1, Ubiquitin-protein Ligase G1, Ubiquitin Carrier Protein G1, E217K, UBC7, UBE2G)
Product Gene Name
anti-UBE2G1 antibody
Product Synonym Names
Anti -UBE2G1, NT (Ubiquitin-conjugating Enzyme E2 G1, Ubiquitin-protein Ligase G1, Ubiquitin Carrier Protein G1, E217K, UBC7, UBE2G)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human UBE2G1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
19,509 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (4172512..4269969, complement). Location: 1q42; 17p13.2
OMIM
601569
3D Structure
ModBase 3D Structure for P62253
Immunogen
Synthetic peptide selected from the N-terminal region of human UBE2G1 (KLH).

Product Categories/Family for anti-UBE2G1 antibody

Antibodies; Abs to Ubiquitin Ligases
Applications Tested/Suitable for anti-UBE2G1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-UBE2G1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-UBE2G1 antibody

Western blot analysis of anti-UBE2G1 Antibody (N-term) in mouse heart tissue lysates (35ug/lane). UBE2G1(arrow) was detected using the purified Pab.
Rabbit Anti-UBE2G1 Polyclonal Antibody – Cat# MBS625692

Western Blot (WB) of anti-UBE2G1 antibody

Western blot analysis of UBE2G1 (arrow) using rabbit polyclonal UBE2G1 Antibody (R11) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the UBE2G1 gene.
Rabbit Anti-UBE2G1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625692

Immunohistochemistry (IHC) of anti-UBE2G1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-UBE2G1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625692

Other Notes

Small volumes of anti-UBE2G1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBE2G1 purchase

MBS625692 is an antibody targeting UBE2G1. Also known as UBE2G1, NT (Ubiquitin-conjugating Enzyme E2 G1, Ubiquitin-protein Ligase G1, Ubiquitin Carrier Protein G1, E217K, UBC7, UBE2G). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UBE2G1. It may not necessarily be applicable to this product.

NCBI GI #
112180338
NCBI GeneID
7326
UniProt Primary Accession #
P62253
UniProt Secondary Accession #
Q99462; B2R7P2; D3DTK0
UniProt Related Accession #
P62253
NCBI Official Full Name
UBE2G1 protein
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2G 1
NCBI Official Symbol
UBE2G1
NCBI Official Synonym Symbols
UBC7; E217K; UBE2G
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 G1
UniProt Synonym Protein Names
E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1
Protein Family
Ubiquitin-conjugating enzyme
UniProt Gene Name
UBE2G1
UniProt Synonym Gene Names
UBE2G
UniProt Entry Name
UB2G1_HUMAN
NCBI Protein Information
ubiquitin-conjugating enzyme E2 G1; ubiquitin-protein ligase G1; ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast); ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7)

NCBI Summary for UBE2G1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq]
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UniProt Comments for UBE2G1

UBE2G1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: cytoplasm

Molecular Function: small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; cellular protein catabolic process
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Research Articles on UBE2G1

1. In endoplasmic reticulum, involved in the degradation of type 2 iodothyronine selenodeiodinase

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-UBE2G1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with anti-UBE2G1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with UBE2G1 and Neoplasms

Organs/Tissues associated with anti-UBE2G1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with UBE2G1 and Liver
 Muscle Antibodies  >1 publications with UBE2G1 and Muscle
 Heart Antibodies  >1 publications with UBE2G1 and Heart
 Brain Antibodies  >1 publications with UBE2G1 and Brain
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