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PHB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625704

PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PHB2, Polyclonal Antibody
Full Product Name
PHB2 (Y248) (BAP, REA, Prohibitin-2, B-cell Receptor-associated Protein BAP37, Repressor Of Estrogen Receptor Activity, D-prohibitin)
Product Gene Name
anti-PHB2 antibody
Product Synonym Names
Anti -PHB2 (Y248) (BAP, REA, Prohibitin-2, B-cell Receptor-associated Protein BAP37, Repressor Of Estrogen Receptor Activity, D-prohibitin)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human PHB2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
33,296 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (7074515..7079981, complement). Location: 12p13
OMIM
610704
3D Structure
ModBase 3D Structure for Q99623
Immunogen
Synthetic peptide corresponding to amino acid residues surrounding Y248 of human PHB2 (KLH).

Product Categories/Family for anti-PHB2 antibody

Antibodies; Abs to Receptors; Estrogen
Applications Tested/Suitable for anti-PHB2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PHB2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PHB2 antibody

Western blot analysis of PHB2-Y248 in MDA-MB435 cell line lysates (35ug/lane).PHB2 (arrow) was detected using the purified Pab.
Rabbit Anti-PHB2 Polyclonal Antibody – Cat# MBS625704

Western Blot (WB) of anti-PHB2 antibody

Western blot analysis of PHB2-Y248 in mouse kidney tissue lysates (35ug/lane). PHB2 (arrow) was detected using the purified Pab.
Rabbit Anti-PHB2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625704

Western Blot (WB) of anti-PHB2 antibody

Western blot analysis of PHB2 (arrow) using PHB2 Antibody (Y248) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PHB2 gene (Lane 2) (Origene Technologies).
Rabbit Anti-PHB2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625704

Immunohistochemistry (IHC) of anti-PHB2 antibody

PHB2 Antibody (Y248) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PHB2 Antibody (Y248) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PHB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625704

Other Notes

Small volumes of anti-PHB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHB2 purchase

MBS625704 is an antibody targeting PHB2. Also known as PHB2 (Y248) (BAP, REA, Prohibitin-2, B-cell Receptor-associated Protein BAP37, Repressor Of Estrogen Receptor Activity, D-prohibitin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHB2. It may not necessarily be applicable to this product.

NCBI GI #
390608669
NCBI GeneID
11331
NCBI Accession #
NP_001254629.1
UniProt Primary Accession #
Q99623
UniProt Secondary Accession #
Q2YDA4; Q7KYU3; Q92978; B4DP75
UniProt Related Accession #
Q99623
GenBank Nucleotide #
NM_001267700.1
NCBI Official Full Name
prohibitin-2 isoform 3
NCBI Official Synonym Full Names
prohibitin 2
NCBI Official Symbol
PHB2
NCBI Official Synonym Symbols
BAP; REA; p22; Bap37; BCAP37; PNAS-141
UniProt Protein Name
Prohibitin-2
UniProt Synonym Protein Names
B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity
Protein Family
Prohibitin
UniProt Gene Name
PHB2
UniProt Synonym Gene Names
BAP; REA
UniProt Entry Name
PHB2_HUMAN
NCBI Protein Information
prohibitin-2; D-prohibitin; B-cell associated protein; repressor of estrogen receptor activity; B-cell receptor-associated protein BAP37

UniProt Comments for PHB2

BAP37: a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy.

Protein type: Mitochondrial; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: protein complex; nuclear matrix; mitochondrion; mitochondrial inner membrane; nucleus

Molecular Function: protein binding; estrogen receptor binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; negative regulation of mammary gland epithelial cell proliferation; negative regulation of estrogen receptor signaling pathway
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Research Articles on PHB2

1. ASURA specifically binds to chromatin when Scc1 is associated with chromatin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PHB2 antibody

 Reference Product  PubMed Publications
 PHB antibody  >16 publications with PHB2 and PHB
 ESR1 antibody  >3 publications with PHB2 and ESR1
 MFN1 antibody  >1 publications with PHB2 and MFN1
 AKT1 antibody  >1 publications with PHB2 and AKT1

Diseases associated with anti-PHB2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with PHB2 and Neoplasms
 Weight Loss Antibodies  >4 publications with PHB2 and Weight Loss
 Breast Neoplasms Antibodies  >3 publications with PHB2 and Breast Neoplasms
 Atrophy Antibodies  >2 publications with PHB2 and Atrophy
 Precancerous Conditions Antibodies  >1 publications with PHB2 and Precancerous Conditions
 Carcinoma, Hepatocellular Antibodies  >1 publications with PHB2 and Carcinoma, Hepatocellular
 Liver Neoplasms, Experimental Antibodies  >1 publications with PHB2 and Liver Neoplasms, Experimental
 Liver Diseases Antibodies  >1 publications with PHB2 and Liver Diseases
 Hypertrophy Antibodies  >1 publications with PHB2 and Hypertrophy
 Adenocarcinoma Antibodies  >1 publications with PHB2 and Adenocarcinoma

Organs/Tissues associated with anti-PHB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with PHB2 and Blood
 Muscle Antibodies  >6 publications with PHB2 and Muscle
 Heart Antibodies  >3 publications with PHB2 and Heart
 Ovary Antibodies  >1 publications with PHB2 and Ovary
 Liver Antibodies  >1 publications with PHB2 and Liver
 Uterus Antibodies  >1 publications with PHB2 and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with PHB2 and Uncharacterized Tissue
 Lung Antibodies  >1 publications with PHB2 and Lung
 Embryonic Tissue Antibodies  >1 publications with PHB2 and Embryonic Tissue
 Nerve Antibodies  >1 publications with PHB2 and Nerve
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