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pla2g4a Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625712

PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and… More details

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Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PLA2G4A, Polyclonal Antibody
Full Product Name
PLA2G4A, ID (Cytosolic Phospholipase A2, cPLA2, Phospholipase A2 Group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4, CPLA2)
Product Gene Name
anti-pla2g4a antibody
Product Synonym Names
Anti -PLA2G4A, ID (Cytosolic Phospholipase A2, cPLA2, Phospholipase A2 Group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4, CPLA2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human PLA2G4A.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
85,413 Da
Chromosome Location
chromosome: Un
3D Structure
ModBase 3D Structure for B1WAZ6
Immunogen
Synthetic peptide selected from the Center region of human PLA2G4A (KLH).

Product Categories/Family for anti-pla2g4a antibody

Antibodies; Abs to Enzymes; Phospholipase
Applications Tested/Suitable for anti-pla2g4a antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-pla2g4a antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-pla2g4a antibody

Western Blot analysis in NCI-H460 cell line lysates (35ug/lane) using MBS625712. PLA2G4A (arrow) was detected using the purified Pab.
Rabbit Anti-pla2g4a Polyclonal Antibody – Cat# MBS625712

Immunohistochemistry (IHC) of anti-pla2g4a antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human lung carcinoma with MBS625712, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS625712 for immunohistochemistry.
Rabbit Anti-pla2g4a Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625712

Testing Data of anti-pla2g4a antibody

Rabbit Anti-pla2g4a Polyclonal Antibody, Testing Data – Cat# MBS625712

Flow Cytometry (FC/FACS) of anti-pla2g4a antibody

Flow Cytometric analysis of NCI-H292 cells using MBS625712 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-pla2g4a Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS625712

Other Notes

Small volumes of anti-pla2g4a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for pla2g4a purchase

MBS625712 is an antibody targeting pla2g4a. Also known as PLA2G4A, ID (Cytosolic Phospholipase A2, cPLA2, Phospholipase A2 Group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4, CPLA2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for pla2g4a. It may not necessarily be applicable to this product.

NCBI GI #
171846323
NCBI GeneID
100145731
NCBI Accession #
AAI61557.1
UniProt Primary Accession #
B1WAZ6
UniProt Related Accession #
B1WAZ6
NCBI Official Full Name
pla2g4a protein
NCBI Official Synonym Full Names
phospholipase A2, group IVA (cytosolic, calcium-dependent)
NCBI Official Symbol
pla2g4a
NCBI Official Synonym Symbols
cPLA2; pla2g4
UniProt Protein Name
Cytosolic phospholipase A2
UniProt Synonym Protein Names
Phospholipase A2 group IVAIncluding the following 2 domains:Phospholipase A2 (EC:3.1.1.4)Alternative name(s):Phosphatidylcholine 2-acylhydrolase
Protein Family
Cytosolic phospholipase
UniProt Gene Name
pla2g4a
UniProt Synonym Gene Names
cpla2; pla2g4; cPLA2
UniProt Entry Name
PA24A_XENTR
NCBI Protein Information
cytosolic phospholipase A2; Phospholipase A2 group IVA

UniProt Comments for pla2g4a

Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

By similarity.

Catalytic activity: Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+

By similarity.

Subcellular location: Cytoplasm

By similarity. Cytoplasmic vesicle

By similarity. Note: Translocates to membrane vesicles in a calcium-dependent fashion

By similarity.

Domain: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+

By similarity.

Sequence similarities: Contains 1 C2 domain.Contains 1 PLA2c domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-pla2g4a antibody

 Reference Product  PubMed Publications
 ptgs2 antibody  >276 publications with pla2g4a and ptgs2
 PLA2G6 antibody  >102 publications with pla2g4a and PLA2G6
 PTGS1 antibody  >87 publications with pla2g4a and PTGS1
 mapk1 antibody  >77 publications with pla2g4a and mapk1
 ALOX5 antibody  >56 publications with pla2g4a and ALOX5
 PLD1 antibody  >5 publications with pla2g4a and PLD1
 LPCAT1 antibody  >1 publications with pla2g4a and LPCAT1

Pathways associated with anti-pla2g4a antibody

 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 Acyl Chain Remodeling Of CL Pathway antibodies  Acyl Chain Remodeling Of CL Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram

Diseases associated with anti-pla2g4a antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >281 publications with pla2g4a and Inflammation
 Neoplasms Antibodies  >216 publications with pla2g4a and Neoplasms
 Necrosis Antibodies  >158 publications with pla2g4a and Necrosis
 Nervous System Diseases Antibodies  >134 publications with pla2g4a and Nervous System Diseases
 Brain Diseases Antibodies  >109 publications with pla2g4a and Brain Diseases
 Gastrointestinal Diseases Antibodies  >49 publications with pla2g4a and Gastrointestinal Diseases
 Asthma Antibodies  >37 publications with pla2g4a and Asthma
 Edema Antibodies  >34 publications with pla2g4a and Edema
 Heart Diseases Antibodies  >33 publications with pla2g4a and Heart Diseases
 Lung Neoplasms Antibodies  >30 publications with pla2g4a and Lung Neoplasms

Organs/Tissues associated with anti-pla2g4a antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >183 publications with pla2g4a and Lung
 Ovary Antibodies  >46 publications with pla2g4a and Ovary
 Intestine Antibodies  >35 publications with pla2g4a and Intestine
 Spleen Antibodies  >20 publications with pla2g4a and Spleen
 Testis Antibodies  >13 publications with pla2g4a and Testis
 Whole Body Antibodies  >2 publications with pla2g4a and Whole Body
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