Rabbit Anti-SYN1 Polyclonal Antibody – Cat# MBS625733

Western blot of rat brain lysate showing specific immunolabeling of the approximately 78kD Synapsin I phosphorylated at S9 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: lambda PPase). The blot is identical to the control except that it was incubated in lambda PPase (1200 units for 30 minutes) before being exposed to the anti-phospho-S9 Synapsin I. The immunolabeling is completely eliminated by treatment with lambda PPase.

Synapsin I (SYN1) Antibody – Rabbit Polyclonal

Name: SYN1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS625733
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625733

Synapsin I is an 85 kD neuron-specific, O-GlcNAcylated phosphoprotein that interacts with synaptic vesicles and regulates neurotransmitter release. It is concentrated in presynaptic terminals where it anchors synaptic vesicles to the underlying cytoskeleton.… More details

$970 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Synapsin I (SYN1), Polyclonal Antibody

Full Product Name

Synapsin I, phosphorylated (Ser9)

Product Gene Name

anti-SYN1 antibody

Product Synonym Names

Anti -Synapsin I, phosphorylated (Ser9)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Xenopus

Form/Format

Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA and 50% glycerol.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Specific for the ~78kD Synapsin I doublet protein phosphorylated at S9 in Western Blots of rat hippocampal lysates. The antibody also weakly labels the ~55kD Synapsin II, which has a similar phosphorylation site to that of S9 on Synapsin I.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

74,111 Da

Chromosome Location

Chromosome: X; NC_000023.10 (47431300..47479256, complement). Location: Xp11.23

OMIM

300491

3D Structure

ModBase 3D Structure for P17600

Immunogen

Phosphopeptide corresponding to amino acid residues surrounding the phospho-S9 of Synapsin I

Product Categories/Family for anti-SYN1 antibody

Antibodies; Abs to Neuroscience

Applications Tested/Suitable for anti-SYN1 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-SYN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SYN1 purchase

MBS625733 is an antibody targeting SYN1. Also known as Synapsin I, phosphorylated (Ser9). Reactive in Human, Mouse, Rat, Xenopus. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SYN1. It may not necessarily be applicable to this product.

NCBI GI #

553654

NCBI GeneID

6853

UniProt Primary Accession #

P17600

UniProt Secondary Accession #

O75825; Q5H9A9; B1AJQ1

UniProt Related Accession #

P17600

NCBI Official Full Name

synapsin I

NCBI Official Synonym Full Names

synapsin I

NCBI Official Symbol

SYN1

NCBI Official Synonym Symbols

SYNI; SYN1a; SYN1b

UniProt Protein Name

Synapsin-1

UniProt Synonym Protein Names

Brain protein 4.1; Synapsin I

Protein Family

Sister chromatid cohesion 1 protein

UniProt Gene Name

SYN1

UniProt Entry Name

SYN1_HUMAN

NCBI Protein Information

synapsin-1; brain protein 4.1; OTTHUMP00000023229; OTTHUMP00000023230

NCBI Summary for SYN1

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

UniProt Comments for SYN1

SYN1: neuronal phosphoprotein which associates with the cytoplasmic surface of synaptic vesicles and binds to the cytoskeleton. May function in the regulation of neurotransmitter release and of axonogenesis and synaptogenesis. Mutations may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Two differentially spiced isoforms have been reported.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: Golgi apparatus; synaptic vesicle; dendrite; cell junction; cytosol

Molecular Function: protein binding; transporter activity; actin binding; catalytic activity; calcium-dependent protein binding; protein kinase binding; ATP binding

Biological Process: synaptic transmission; metabolic process; neurotransmitter secretion; regulation of neurotransmitter secretion

Disease: Epilepsy, X-linked, With Variable Learning Disabilities And Behavior Disorders

Research Articles on SYN1

1. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SYN1 antibody

Reference Product	PubMed Publications
SYN2 antibody	>7 publications with SYN1 and SYN2
SYN3 antibody	>5 publications with SYN1 and SYN3
PAK3 antibody	>1 publications with SYN1 and PAK3

Pathways associated with anti-SYN1 antibody

Products by Pathway	Pathway Diagram
Dopamine Neurotransmitter Release Cycle Pathway antibodies	Dopamine Neurotransmitter Release Cycle Pathway Diagram
Monoamine Transport Pathway antibodies	Monoamine Transport Pathway Diagram
Neurotransmitter Release Cycle Pathway antibodies	Neurotransmitter Release Cycle Pathway Diagram
Serotonin Neurotransmitter Release Cycle Pathway antibodies	Serotonin Neurotransmitter Release Cycle Pathway Diagram
Synaptic Transmission Pathway antibodies	Synaptic Transmission Pathway Diagram
Transmission Across Chemical Synapses Pathway antibodies	Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-SYN1 antibody

Disease Name	Pubmed Publications
Epilepsy Antibodies	>4 publications with SYN1 and Epilepsy
Neoplasms Antibodies	>4 publications with SYN1 and Neoplasms
Central Nervous System Diseases Antibodies	>3 publications with SYN1 and Central Nervous System Diseases
Infertility, Male Antibodies	>2 publications with SYN1 and Infertility, Male
Seizures Antibodies	>2 publications with SYN1 and Seizures
Blood Coagulation Disorders Antibodies	>2 publications with SYN1 and Blood Coagulation Disorders
Neurodegenerative Diseases Antibodies	>1 publications with SYN1 and Neurodegenerative Diseases
Mammary Neoplasms, Experimental Antibodies	>1 publications with SYN1 and Mammary Neoplasms, Experimental
Epilepsy, Tonic-Clonic Antibodies	>1 publications with SYN1 and Epilepsy, Tonic-Clonic
Lymphoma Antibodies	>1 publications with SYN1 and Lymphoma

Organs/Tissues associated with anti-SYN1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>12 publications with SYN1 and Brain
Nerve Antibodies	>5 publications with SYN1 and Nerve
Eye Antibodies	>2 publications with SYN1 and Eye
Connective Tissue Antibodies	>1 publications with SYN1 and Connective Tissue
Lung Antibodies	>1 publications with SYN1 and Lung
Placenta Antibodies	>1 publications with SYN1 and Placenta