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SENP8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625768

MBS625768 is an antibody targeting SENP8. Also known as SENP8, NT (Sentrin-specific Protease 8, Sentrin/SUMO-specific Protease SENP8, Protease, Cysteine 2, NEDD8-specific Protease 1, Deneddylase-1, DEN1, NEDP1, PRSC2, FKSG8). Reactive in Human, Mouse. Host:… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SENP8, Polyclonal Antibody
Full Product Name
SENP8, NT (Sentrin-specific Protease 8, Sentrin/SUMO-specific Protease SENP8, Protease, Cysteine 2, NEDD8-specific Protease 1, Deneddylase-1, DEN1, NEDP1, PRSC2, FKSG8)
Product Gene Name
Product Synonym Names
Anti -SENP8, NT (Sentrin-specific Protease 8, Sentrin/SUMO-specific Protease SENP8, Protease, Cysteine 2, NEDD8-specific Protease 1, Deneddylase-1, DEN1, NEDP1, PRSC2, FKSG8)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human SENP8. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
24,107 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (72406599..72433311). Location: 15q23
OMIM
608659
3D Structure
ModBase 3D Structure for Q96LD8
Immunogen
Synthetic peptide selected from the N-terminal region of human SENP8 (KLH).

Product Categories/Family for anti-SENP8 antibody

Applications Tested/Suitable for anti-SENP8 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SENP8 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-SENP8 antibody

Western Blot analysis of MBS625768 in mouse spleen lysate. SENP8 (arrow) was detected using MBS625768. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Rabbit Anti-SENP8 Polyclonal Antibody – Cat# MBS625768

Western Blot (WB) of anti-SENP8 antibody

Western Blot analysis of SENP8 (arrow) using MBS625768. 293 cell lysates (2ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SENP8 gene.
Rabbit Anti-SENP8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625768

Other Notes

Small volumes of anti-SENP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sentrin-specific protease 8
NCBI Official Synonym Full Names
SUMO/sentrin specific peptidase family member 8
NCBI Official Symbol
SENP8
NCBI Official Synonym Symbols
DEN1; NEDP1; PRSC2
UniProt Protein Name
Sentrin-specific protease 8
UniProt Synonym Protein Names
Deneddylase-1; NEDD8-specific protease 1; Protease, cysteine 2; Sentrin/SUMO-specific protease SENP8
UniProt Gene Name
SENP8
UniProt Synonym Gene Names
DEN1; NEDP1; PRSC2
UniProt Entry Name
SENP8_HUMAN
NCBI Protein Information
sentrin-specific protease 8; deneddylase 1; deneddylase-1; OTTHUMP00000164640; protease, cysteine 2; NEDD8-specific protease 1; NEDD8 specific-protease cysteine 2; SUMO sentrin specific protease family member 8

NCBI Summary for SENP8

This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.
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UniProt Comments for SENP8

SENP8: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Belongs to the peptidase C48 family.

Protein type: Protease; EC 3.4.22.68

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: cytoplasm; nucleus

Molecular Function: NEDD8-specific protease activity

Biological Process: protein deneddylation; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SENP8 antibody

 Reference Product  PubMed Publications
 NEDD8 antibody  >12 publications with SENP8 and NEDD8

Diseases associated with anti-SENP8 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with SENP8 and Neoplasms

Organs/Tissues associated with anti-SENP8 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with SENP8 and Kidney
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