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GGPS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625780

Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300aa human protein contains 5 conserved domains… More details

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Product Overview

Online Datasheet in PDF
Product Name
GGPS1, Polyclonal Antibody
Full Product Name
GGPS1, CT (Geranylgeranyl Pyrophosphate Synthetase, GGPP Synthetase, GGPPSASE, Geranylgeranyl Diphosphate Synthase)
Product Gene Name
anti-GGPS1 antibody
Product Synonym Names
Anti -GGPS1, CT (Geranylgeranyl Pyrophosphate Synthetase, GGPP Synthetase, GGPPSASE, Geranylgeranyl Diphosphate Synthase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human GGPS1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,871 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (235491753..235507847). Location: 1q43
OMIM
606982
3D Structure
ModBase 3D Structure for O95749
Immunogen
Synthetic peptide selected from the C-terminal region of human GGPS1 (KLH).

Product Categories/Family for anti-GGPS1 antibody

Antibodies; Abs to Enzymes; Synthetase
Applications Tested/Suitable for anti-GGPS1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GGPS1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-GGPS1 antibody

Western blot analysis ofGGPS1 Antibody (C-term) in mouse cerbellum tissue lysates (35ug/lane). GGPS1 (arrow) was detected using the purified Pab.
Rabbit Anti-GGPS1 Polyclonal Antibody – Cat# MBS625780

Immunohistochemistry (IHC) of anti-GGPS1 antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with GGPS1 Antibody (C-term)(AP2419b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-GGPS1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625780

Other Notes

Small volumes of anti-GGPS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GGPS1 purchase

MBS625780 is an antibody targeting GGPS1. Also known as GGPS1, CT (Geranylgeranyl Pyrophosphate Synthetase, GGPP Synthetase, GGPPSASE, Geranylgeranyl Diphosphate Synthase). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GGPS1. It may not necessarily be applicable to this product.

NCBI GI #
83700220
NCBI GeneID
9453
NCBI Accession #
NP_001032354.1
UniProt Primary Accession #
O95749
UniProt Secondary Accession #
Q5T2C8; Q6NW19
UniProt Related Accession #
O95749
GenBank Nucleotide #
NM_001037277.1
NCBI Official Full Name
geranylgeranyl pyrophosphate synthase
NCBI Official Synonym Full Names
geranylgeranyl diphosphate synthase 1
NCBI Official Symbol
GGPS1
NCBI Official Synonym Symbols
GGPPS; GGPPS1
UniProt Protein Name
Geranylgeranyl pyrophosphate synthase
UniProt Synonym Protein Names
(2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Farnesyltranstransferase (EC:2.5.1.29); Geranylgeranyl diphosphate synthase; Geranyltranstransferase (EC:2.5.1.10)
Protein Family
Heterodimeric geranylgeranyl pyrophosphate synthase
UniProt Gene Name
GGPS1
UniProt Synonym Gene Names
GGPP synthase; GGPPSase
UniProt Entry Name
GGPPS_HUMAN
NCBI Protein Information
geranylgeranyl pyrophosphate synthase; GGPPSase; GGPP synthase; geranyltranstransferase; farnesyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosphate synthase

NCBI Summary for GGPS1

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
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UniProt Comments for GGPS1

GGPS1: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Belongs to the FPP/GGPP synthase family.

Protein type: EC 2.5.1.10; Transferase; Motility/polarity/chemotaxis; EC 2.5.1.29; EC 2.5.1.1; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: cytosol

Molecular Function: geranyltranstransferase activity; dimethylallyltranstransferase activity; farnesyltranstransferase activity; metal ion binding

Biological Process: isoprenoid metabolic process; geranylgeranyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; farnesyl diphosphate biosynthetic process; cholesterol biosynthetic process
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Research Articles on GGPS1

1. the Egr-1/GGPPS/Erk1/2 pathway is responsible for insulin resistance during hyperinsulinism

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GGPS1 antibody

 Reference Product  PubMed Publications
 FDPS antibody  >1 publications with GGPS1 and FDPS

Pathways associated with anti-GGPS1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway antibodies  Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
 Geranylgeranyldiphosphate Biosynthesis Pathway antibodies  Geranylgeranyldiphosphate Biosynthesis Pathway Diagram
 Geranylgeranyldiphosphate Biosynthesis Pathway antibodies  Geranylgeranyldiphosphate Biosynthesis Pathway Diagram
 Superpathway Of Cholesterol Biosynthesis antibodies  Superpathway Of Cholesterol Biosynthesis Diagram

Diseases associated with anti-GGPS1 antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >2 publications with GGPS1 and Insulin Resistance

Organs/Tissues associated with anti-GGPS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with GGPS1 and Bone
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