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AGR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625782

Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
AGR2, Polyclonal Antibody
Full Product Name
AGR2, ID (Anterior Gradient Protein 2 Homolog, Secreted Cement Gland Protein XAG-2 Homolog, AG-2, hAG-2, HPC8, AG2, Anterior Gradient 2, UNQ515/PRO1030)
Product Gene Name
anti-AGR2 antibody
Product Synonym Names
Anti -AGR2, ID (Anterior Gradient Protein 2 Homolog, Secreted Cement Gland Protein XAG-2 Homolog, AG-2, hAG-2, HPC8, AG2, Anterior Gradient 2, UNQ515/PRO1030)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human AGR2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
19,979 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (16832264..16844738, complement). Location: 7p21.3
OMIM
606358
3D Structure
ModBase 3D Structure for O95994
Immunogen
Synthetic peptide selected from the Center region of human AGR2 (KLH).

Product Categories/Family for anti-AGR2 antibody

Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-AGR2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AGR2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-AGR2 antibody

AGR2 Antibody (Center) western blot analysis in HT29,MCF-7,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the AGR2 antibody detected the AGR2 protein (arrow).
Rabbit Anti-AGR2 Polyclonal Antibody – Cat# MBS625782

Immunohistochemistry (IHC) of anti-AGR2 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with AGR2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-AGR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625782

Other Notes

Small volumes of anti-AGR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGR2 purchase

MBS625782 is an antibody targeting AGR2. Also known as AGR2, ID (Anterior Gradient Protein 2 Homolog, Secreted Cement Gland Protein XAG-2 Homolog, AG-2, hAG-2, HPC8, AG2, Anterior Gradient 2, UNQ515/PRO1030). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AGR2. It may not necessarily be applicable to this product.

NCBI GI #
5453541
NCBI GeneID
10551
NCBI Accession #
NP_006399.1
UniProt Primary Accession #
O95994
UniProt Related Accession #
O95994; Q4JM46; Q4JM47; Q53G64
GenBank Nucleotide #
NM_006408.3
NCBI Official Full Name
anterior gradient protein 2 homolog
NCBI Official Synonym Full Names
anterior gradient homolog 2 (Xenopus laevis)
NCBI Official Symbol
AGR2
NCBI Official Synonym Symbols
AG2; GOB-4; HAG-2; XAG-2; PDIA17
UniProt Protein Name
Anterior gradient protein 2 homolog
UniProt Synonym Protein Names
HPC8; Secreted cement gland protein XAG-2 homolog
Protein Family
Anterior gradient protein
UniProt Gene Name
AGR2
UniProt Synonym Gene Names
AG2
UniProt Entry Name
AGR2_HUMAN
NCBI Protein Information
anterior gradient protein 2 homolog; AG-2; HPC8; OTTHUMP00000116014; OTTHUMP00000201755; anterior gradient 2 homolog; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17

UniProt Comments for AGR2

AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.

Protein type: Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region

Molecular Function: protein binding
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Research Articles on AGR2

1. AGR2 is a potential biomarker for the diagnosis of mucinous ovarian cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-AGR2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >47 publications with AGR2 and Neoplasms
 Carcinoma Antibodies  >24 publications with AGR2 and Carcinoma
 Breast Neoplasms Antibodies  >20 publications with AGR2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >18 publications with AGR2 and Adenocarcinoma
 Skin Diseases Antibodies  >17 publications with AGR2 and Skin Diseases
 Urogenital Neoplasms Antibodies  >15 publications with AGR2 and Urogenital Neoplasms
 Neoplasm Metastasis Antibodies  >14 publications with AGR2 and Neoplasm Metastasis
 Male Urogenital Diseases Antibodies  >12 publications with AGR2 and Male Urogenital Diseases
 Prostatic Neoplasms Antibodies  >10 publications with AGR2 and Prostatic Neoplasms
 Intestinal Diseases Antibodies  >8 publications with AGR2 and Intestinal Diseases

Organs/Tissues associated with anti-AGR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >16 publications with AGR2 and Prostate
 Intestine Antibodies  >12 publications with AGR2 and Intestine
 Lung Antibodies  >9 publications with AGR2 and Lung
 Larynx Antibodies  >5 publications with AGR2 and Larynx
 Liver Antibodies  >3 publications with AGR2 and Liver
 Bladder Antibodies  >3 publications with AGR2 and Bladder
 Pancreas Antibodies  >3 publications with AGR2 and Pancreas
 Stomach Antibodies  >3 publications with AGR2 and Stomach
 Ovary Antibodies  >2 publications with AGR2 and Ovary
 Pharynx Antibodies  >2 publications with AGR2 and Pharynx
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