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Vaccinia Related Kinase 1 (VRK1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625783

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Vaccinia Related Kinase 1 (VRK1), Polyclonal Antibody
Full Product Name
Vaccinia Related Kinase 1 (VRK1, Serine/threonine-protein kinase VRK1)
Product Gene Name
anti-VRK1 antibody
Product Synonym Names
Anti -Vaccinia Related Kinase 1 (VRK1, Serine/threonine-protein kinase VRK1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human VRK1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,476 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (97263684..97347951). Location: 14q32
OMIM
602168
3D Structure
ModBase 3D Structure for Q99986
Immunogen
Synthetic peptide selected from the center region of human VRK1 (KLH).

Product Categories/Family for anti-VRK1 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-VRK1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-VRK1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-VRK1 antibody

The anti-VRK1 Pab is used in Western blot to detect VRK1 in mouse lung tissue lysate (Lane 1) and HL-60 cell lysate (Lane 2).
Rabbit Anti-VRK1 Polyclonal Antibody – Cat# MBS625783

Western Blot (WB) of anti-VRK1 antibody

Western blot analysis of VRK1 (arrow) using rabbit polyclonal VRK1 Antibody (E381) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the VRK1 gene.
Rabbit Anti-VRK1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS625783

Other Notes

Small volumes of anti-VRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VRK1 purchase

MBS625783 is an antibody targeting VRK1. Also known as Vaccinia Related Kinase 1 (VRK1, Serine/threonine-protein kinase VRK1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VRK1. It may not necessarily be applicable to this product.

NCBI GI #
109730507
NCBI GeneID
7443
UniProt Primary Accession #
Q99986
UniProt Secondary Accession #
Q3SYL2
UniProt Related Accession #
Q99986
NCBI Official Full Name
Vaccinia related kinase 1
NCBI Official Synonym Full Names
vaccinia related kinase 1
NCBI Official Symbol
VRK1
NCBI Official Synonym Symbols
PCH1; MGC117401; MGC138280; MGC142070
UniProt Protein Name
Serine/threonine-protein kinase VRK1
UniProt Synonym Protein Names
Vaccinia-related kinase 1
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
VRK1
UniProt Entry Name
VRK1_HUMAN
NCBI Protein Information
serine/threonine-protein kinase VRK1; vaccinia-related kinase 1; vaccinia virus B1R-related kinase 1

UniProt Comments for VRK1

VRK1: Serine/threonine kinase that phosphorylates Thr-18 of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1 (PCH1); also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1 is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA). Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; CK1 group; VRK family

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: nucleoplasm; Golgi stack; cytoplasm; nucleolus; spindle; cytosol; nucleus

Molecular Function: histone serine kinase activity (H3-S10 specific); protein serine/threonine kinase activity; protein binding; nucleosomal histone binding; ATP binding; protein kinase activity

Biological Process: mitosis; regulation of cell shape; mitotic nuclear envelope reassembly; Wnt receptor signaling pathway; cell division; protein amino acid autophosphorylation; mitotic nuclear envelope disassembly; endocytosis; mitotic cell cycle; protein amino acid phosphorylation

Disease: Pontocerebellar Hypoplasia, Type 1a
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Research Articles on VRK1

1. vrk1 gene mutation can be excluded in 2 Chinese pedigrees of the first and second branchial arch syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VRK1 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >1 publications with VRK1 and TP53

Diseases associated with anti-VRK1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with VRK1 and Neoplasms
 Leukemia Antibodies  >3 publications with VRK1 and Leukemia
 Skin Diseases Antibodies  >2 publications with VRK1 and Skin Diseases
 Lung Diseases Antibodies  >2 publications with VRK1 and Lung Diseases
 Carcinoma, Squamous Cell Antibodies  >2 publications with VRK1 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >2 publications with VRK1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >2 publications with VRK1 and Breast Neoplasms
 Head and Neck Neoplasms Antibodies  >1 publications with VRK1 and Head and Neck Neoplasms
 Eye Abnormalities Antibodies  >1 publications with VRK1 and Eye Abnormalities
 Intestinal Diseases Antibodies  >1 publications with VRK1 and Intestinal Diseases

Organs/Tissues associated with anti-VRK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with VRK1 and Liver
 Testis Antibodies  >3 publications with VRK1 and Testis
 Muscle Antibodies  >2 publications with VRK1 and Muscle
 Thymus Antibodies  >2 publications with VRK1 and Thymus
 Blood Antibodies  >2 publications with VRK1 and Blood
 Lung Antibodies  >2 publications with VRK1 and Lung
 Eye Antibodies  >1 publications with VRK1 and Eye
 Embryonic Tissue Antibodies  >1 publications with VRK1 and Embryonic Tissue
 Spleen Antibodies  >1 publications with VRK1 and Spleen
 Brain Antibodies  >1 publications with VRK1 and Brain
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