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MERTK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625799

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

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Product Overview

Online Datasheet in PDF
Product Name
MerTK, Polyclonal Antibody
Full Product Name
MerTK, NT (c-MER, c-Mer Proto-oncogene Tyrosine Kinase, MER, MER Receptor Tyrosine Kinase, MGC133349, Proto-oncogene c-Mer, RP38, Tyrosine-protein Kinase Mer)
Product Gene Name
anti-MERTK antibody
Product Synonym Names
Anti -MerTK, NT (c-MER, c-Mer Proto-oncogene Tyrosine Kinase, MER, MER Receptor Tyrosine Kinase, MGC133349, Proto-oncogene c-Mer, RP38, Tyrosine-protein Kinase Mer)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human MERK. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
90,980 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (112656191..112786945). Location: 2q14.1
3D Structure
ModBase 3D Structure for Q1RMG3
Immunogen
Synthetic peptide selected from the N-terminal region of human MERK (KLH).

Product Categories/Family for anti-MERTK antibody

Antibodies; Abs to Tyrosine Kinases
Applications Tested/Suitable for anti-MERTK antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MERTK antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-MERTK antibody

Western blot analysis of anti-MERK Pab in NIH/3T3 cell lysate. MERK (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Rabbit Anti-MERTK Polyclonal Antibody – Cat# MBS625799

Immunohistochemistry (IHC) of anti-MERTK antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with MERK antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-MERTK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625799

Other Notes

Small volumes of anti-MERTK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MERTK purchase

MBS625799 is an antibody targeting MERTK. Also known as MerTK, NT (c-MER, c-Mer Proto-oncogene Tyrosine Kinase, MER, MER Receptor Tyrosine Kinase, MGC133349, Proto-oncogene c-Mer, RP38, Tyrosine-protein Kinase Mer). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MERTK. It may not necessarily be applicable to this product.

NCBI GI #
109732052
NCBI GeneID
10461
UniProt Primary Accession #
Q1RMG3
UniProt Related Accession #
Q07941; Q12866; Q1RMG3; Q53QW0; Q53R53; Q96T45
NCBI Official Full Name
MERTK protein
NCBI Official Synonym Full Names
c-mer proto-oncogene tyrosine kinase
NCBI Official Symbol
MERTK
NCBI Official Synonym Symbols
MER; RP38; c-mer; MGC133349
UniProt Protein Name
MERTK protein
Protein Family
Tyrosine-protein kinase
UniProt Gene Name
MERTK
UniProt Entry Name
Q1RMG3_HUMAN
NCBI Protein Information
tyrosine-protein kinase Mer; STK kinase; OTTHUMP00000161952; OTTHUMP00000203538; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK

NCBI Summary for MERTK

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq]
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UniProt Comments for MERTK

Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Protein type: Protein kinase, TK; Oncoprotein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Axl family

Chromosomal Location of Human Ortholog: 2q14.1

Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: platelet activation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell

Disease: Retinitis Pigmentosa 38
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Research Articles on MERTK

1. Gas6 and Tyro3, Axl and Mer (TAM) receptors have roles in human and murine platelet activation and thrombus stabilization

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MERTK antibody

 Reference Product  PubMed Publications
 GAS6 antibody  >44 publications with MERTK and GAS6
 VAV1 antibody  >2 publications with MERTK and VAV1
 TNK2 antibody  >2 publications with MERTK and TNK2
 GRB2 antibody  >2 publications with MERTK and GRB2

Pathways associated with anti-MERTK antibody

 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-MERTK antibody

 Disease Name  Pubmed Publications
 Retinitis Pigmentosa Antibodies  >36 publications with MERTK and Retinitis Pigmentosa
 Neoplasms Antibodies  >31 publications with MERTK and Neoplasms
 Inflammation Antibodies  >26 publications with MERTK and Inflammation
 Disease Models, Animal Antibodies  >25 publications with MERTK and Disease Models, Animal
 Nervous System Diseases Antibodies  >18 publications with MERTK and Nervous System Diseases
 Necrosis Antibodies  >15 publications with MERTK and Necrosis
 Atherosclerosis Antibodies  >11 publications with MERTK and Atherosclerosis
 Nerve Degeneration Antibodies  >9 publications with MERTK and Nerve Degeneration
 Leukemia Antibodies  >8 publications with MERTK and Leukemia
 Cell Transformation, Neoplastic Antibodies  >8 publications with MERTK and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-MERTK antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >56 publications with MERTK and Eye
 Blood Antibodies  >47 publications with MERTK and Blood
 Bone Antibodies  >17 publications with MERTK and Bone
 Brain Antibodies  >11 publications with MERTK and Brain
 Testis Antibodies  >7 publications with MERTK and Testis
 Kidney Antibodies  >7 publications with MERTK and Kidney
 Embryonic Tissue Antibodies  >5 publications with MERTK and Embryonic Tissue
 Lung Antibodies  >4 publications with MERTK and Lung
 Muscle Antibodies  >4 publications with MERTK and Muscle
 Prostate Antibodies  >3 publications with MERTK and Prostate
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