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PIGR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625948

PIGR binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the… More details

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Product Overview

Online Datasheet in PDF
Product Name
PIGR, Polyclonal Antibody
Full Product Name
PIGR, CT (Polymeric Immunoglobulin Receptor, Poly-Ig Receptor, FLJ22667, Hepatocellular Carcinoma-associated Protein TB6, MGC125361, MGC125362)
Product Gene Name
anti-PIGR antibody
Product Synonym Names
Anti -PIGR, CT (Polymeric Immunoglobulin Receptor, Poly-Ig Receptor, FLJ22667, Hepatocellular Carcinoma-associated Protein TB6, MGC125361, MGC125362)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human PIGR.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
83,284 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (207101867..207119811, complement). Location: 1q31-q41
OMIM
173880
3D Structure
ModBase 3D Structure for P01833
Immunogen
Synthetic peptide selected from the C-terminal region of human PIGR (KLH).

Product Categories/Family for anti-PIGR antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-PIGR antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PIGR antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-PIGR antibody

Western blot analysis of PIGR Antibody (C-term) in HepG2(lane 1),K562(lane 2),HL-60(lane 3) cell line lysates (35ug/lane).PIGR (arrow) was detected using the purified Pab.
Rabbit Anti-PIGR Polyclonal Antibody – Cat# MBS625948

Immunohistochemistry (IHC) of anti-PIGR antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma with PIGR Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PIGR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625948

Immunohistochemistry (IHC) of anti-PIGR antibody

PIGR Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PIGR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PIGR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625948

Immunofluorescence (IF) of anti-PIGR antibody

Confocal immunofluorescent analysis of PIGR Antibody (C-term) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-PIGR Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS625948

Immunofluorescence (IF) of anti-PIGR antibody

Confocal immunofluorescent analysis of PIGR Antibody (C-term) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-PIGR Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS625948

Other Notes

Small volumes of anti-PIGR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIGR purchase

MBS625948 is an antibody targeting PIGR. Also known as PIGR, CT (Polymeric Immunoglobulin Receptor, Poly-Ig Receptor, FLJ22667, Hepatocellular Carcinoma-associated Protein TB6, MGC125361, MGC125362). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PIGR. It may not necessarily be applicable to this product.

NCBI GI #
31377806
NCBI GeneID
5284
NCBI Accession #
NP_002635.2
UniProt Primary Accession #
P01833
UniProt Secondary Accession #
Q68D81; Q8IZY7
UniProt Related Accession #
P01833; Q8TE27
GenBank Nucleotide #
NM_002644.3
NCBI Official Full Name
polymeric immunoglobulin receptor
NCBI Official Synonym Full Names
polymeric immunoglobulin receptor
NCBI Official Symbol
PIGR
NCBI Official Synonym Symbols
FLJ22667; MGC125361; MGC125362
UniProt Protein Name
Polymeric immunoglobulin receptor
UniProt Synonym Protein Names
Hepatocellular carcinoma-associated protein TB6
Protein Family
Polymeric immunoglobulin receptor
UniProt Gene Name
PIGR
UniProt Entry Name
PIGR_HUMAN
NCBI Protein Information
polymeric immunoglobulin receptor; poly-Ig receptor; OTTHUMP00000034748; hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6

NCBI Summary for PIGR

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
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UniProt Comments for PIGR

PIGR: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Protein type: Membrane protein, integral; Immunoglobulin superfamily; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q31-q41

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: polymeric immunoglobulin receptor activity

Biological Process: epidermal growth factor receptor signaling pathway; retinal homeostasis; detection of chemical stimulus involved in sensory perception of bitter taste; receptor clustering; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor

Disease: Iga Nephropathy, Susceptibility To, 1
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Research Articles on PIGR

1. Data illustrate the importance of a coordinated signaling between Src PTKs, ERK1/2, and JNK during pIgR-mediated uptake of pneumococci by host epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PIGR antibody

 Reference Product  PubMed Publications
 CCL5 antibody  >2 publications with PIGR and CCL5
 RAB3B antibody  >1 publications with PIGR and RAB3B

Pathways associated with anti-PIGR antibody

 Products by Pathway  Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with anti-PIGR antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >20 publications with PIGR and Inflammation
 Neoplasms Antibodies  >19 publications with PIGR and Neoplasms
 Necrosis Antibodies  >17 publications with PIGR and Necrosis
 Immune System Diseases Antibodies  >16 publications with PIGR and Immune System Diseases
 Kidney Diseases Antibodies  >9 publications with PIGR and Kidney Diseases
 Adenocarcinoma Antibodies  >7 publications with PIGR and Adenocarcinoma
 Female Urogenital Diseases Antibodies  >7 publications with PIGR and Female Urogenital Diseases
 Male Urogenital Diseases Antibodies  >7 publications with PIGR and Male Urogenital Diseases
 Liver Diseases Antibodies  >5 publications with PIGR and Liver Diseases
 Colonic Neoplasms Antibodies  >5 publications with PIGR and Colonic Neoplasms

Organs/Tissues associated with anti-PIGR antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >59 publications with PIGR and Intestine
 Kidney Antibodies  >56 publications with PIGR and Kidney
 Liver Antibodies  >34 publications with PIGR and Liver
 Lung Antibodies  >24 publications with PIGR and Lung
 Mammary Gland Antibodies  >15 publications with PIGR and Mammary Gland
 Uterus Antibodies  >6 publications with PIGR and Uterus
 Muscle Antibodies  >4 publications with PIGR and Muscle
 Brain Antibodies  >4 publications with PIGR and Brain
 Pharynx Antibodies  >3 publications with PIGR and Pharynx
 Stomach Antibodies  >3 publications with PIGR and Stomach
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