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GGTLA1 (GGT5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626110

This gene is a member of gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert… More details

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Product Overview

Online Datasheet in PDF
Product Name
GGTLA1 (GGT5), Polyclonal Antibody
Full Product Name
GGTLA1, NT (Gamma-glutamyltransferase 5, Gamma-glutamyltranspeptidase 5, GGT 5, GGT5, Gamma-glutamyltransferase-like Activity 1, Gamma-glutamyl Transpeptidase-related Enzyme, GGT-rel)
Product Gene Name
anti-GGT5 antibody
Product Synonym Names
Anti -GGTLA1, NT (Gamma-glutamyltransferase 5, Gamma-glutamyltranspeptidase 5, GGT 5, GGT5, Gamma-glutamyltransferase-like Activity 1, Gamma-glutamyl Transpeptidase-related Enzyme, GGT-rel)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human GGTLA1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
62,261 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (24615622..24641317, complement). Location: 22q11.23
OMIM
137168
3D Structure
ModBase 3D Structure for P36269
Immunogen
Synthetic peptide selected from the N-terminal region of human GGTLA1 (KLH).

Product Categories/Family for anti-GGT5 antibody

Antibodies; Abs to Enzymes;  Transferase
Applications Tested/Suitable for anti-GGT5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-GGT5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-GGT5 antibody

Western blot analysis of GGTLA1 antibody (N-term) in Y79 cell line lysates (35ug/lane). GGTLA1 (arrow) was detected using the purified Pab.
Rabbit Anti-GGT5 Polyclonal Antibody – Cat# MBS626110

Western Blot (WB) of anti-GGT5 antibody

Western blot analysis of GGTLA1 antibody (N-term) in mouse heart tissue lysates (35ug/lane). GGTLA1 (arrow) was detected using the purified Pab.
Rabbit Anti-GGT5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS626110

Immunohistochemistry (IHC) of anti-GGT5 antibody

Formalin-fixed and paraffin-embedded human brain reacted with GGTLA1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-GGT5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS626110

Flow Cytometry (FC/FACS) of anti-GGT5 antibody

GGTLA1 Antibody (N-term) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-GGT5 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS626110

Other Notes

Small volumes of anti-GGT5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GGT5 purchase

MBS626110 is an antibody targeting GGT5. Also known as GGTLA1, NT (Gamma-glutamyltransferase 5, Gamma-glutamyltranspeptidase 5, GGT 5, GGT5, Gamma-glutamyltransferase-like Activity 1, Gamma-glutamyl Transpeptidase-related Enzyme, GGT-rel). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GGT5. It may not necessarily be applicable to this product.

NCBI GI #
153266907
NCBI GeneID
2687
NCBI Accession #
NP_001093252.1
UniProt Primary Accession #
P36269
UniProt Secondary Accession #
Q53XM9; Q6GMP0; Q96FC1; Q9UFM5
UniProt Related Accession #
P36269
GenBank Nucleotide #
NM_001099782.1
NCBI Official Full Name
gamma-glutamyltransferase 5 isoform c
NCBI Official Synonym Full Names
gamma-glutamyltransferase 5
NCBI Official Symbol
GGT5
NCBI Official Synonym Symbols
GGTLA1; GGT-REL
UniProt Protein Name
Gamma-glutamyltransferase 5
UniProt Synonym Protein Names
Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Glutathione hydrolase 5 (EC:3.4.19.13); Leukotriene-C4 hydrolase (EC:3.4.19.14)Cleaved into the following 2 chains:Gamma-glutamyltransferase 5 heavy chain; Gamma-glutamyltransferase 5 light chain
Protein Family
Gamma-glutamyltransferase
UniProt Gene Name
GGT5
UniProt Synonym Gene Names
GGTLA1; GGT 5; GGT-rel
UniProt Entry Name
GGT5_HUMAN
NCBI Protein Information
gamma-glutamyltransferase 5; GGT 5; glutathione hydrolase 5; leukotriene-C4 hydrolase; gamma-glutamyl cleaving enzyme; gamma-glutamyltranspeptidase 5; gamma-glutamyltransferase-like activity 1; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyl transpeptidase-related protein

NCBI Summary for GGT5

This gene is a member of a gene family that encodes gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for GGT5

GGT5: Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.3.2.2; Lipid Metabolism - arachidonic acid; EC 3.4.19.14; Other Amino Acids Metabolism - cyanoamino acid; EC 3.4.19.13; Other Amino Acids Metabolism - taurine and hypotaurine; Transferase; Other Amino Acids Metabolism - selenoamino acid; Other Amino Acids Metabolism - glutathione; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: anchored to external side of plasma membrane; integral to membrane; plasma membrane

Molecular Function: gamma-glutamyltransferase activity

Biological Process: amino acid metabolic process; leukotriene biosynthetic process; glutathione metabolic process; glutathione biosynthetic process; arachidonic acid metabolic process; leukotriene metabolic process; inflammatory response; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GGT5 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram

Diseases associated with anti-GGT5 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1 publications with GGT5 and Cardiovascular Diseases
 Asthma Antibodies  >1 publications with GGT5 and Asthma

Organs/Tissues associated with anti-GGT5 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with GGT5 and Bone
 Lung Antibodies  >1 publications with GGT5 and Lung
 Connective Tissue Antibodies  >1 publications with GGT5 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with GGT5 and Uncharacterized Tissue
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