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CDK14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626157

PFTK1, a member of the CDC2/CDKX subfamily of Ser/Thr protein kinases, may play a role in meiosis as well as in neuron differentiation and/or function It is highly expressed in brain, pancreas, kidney, heart, testis and ovary, and also detected at lower… More details

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Product Overview

Online Datasheet in PDF
Product Name
PFTK1 (CDK14), Polyclonal Antibody
Full Product Name
PFTK1, NT (Cell Division Protein Kinase 14, Cyclin-dependent Kinase 14, CDK14, KIAA0834, PFTAIRE1, hPFTAIRE1, Serine/threonine Protein Kinase PFTAIRE-1)
Product Gene Name
anti-CDK14 antibody
Product Synonym Names
Anti -PFTK1, NT (Cell Division Protein Kinase 14, Cyclin-dependent Kinase 14, CDK14, KIAA0834, PFTAIRE1, hPFTAIRE1, Serine/threonine Protein Kinase PFTAIRE-1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PFTK1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
53,057 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (90338712..90839904). Location: 7q21-q22
OMIM
610679
3D Structure
ModBase 3D Structure for O94921
Immunogen
Synthetic peptide selected from the N-terminal region of human PFTK1 (KLH).

Product Categories/Family for anti-CDK14 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-CDK14 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CDK14 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-CDK14 antibody

Western blot analysis of PFTK1 antibody (N-term) in mouse cerebellum tissue lysates (35ug/lane). PFTK1 (arrow) was detected using the purified Pab.
Rabbit Anti-CDK14 Polyclonal Antibody – Cat# MBS626157

Immunohistochemistry (IHC) of anti-CDK14 antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with PFTK1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CDK14 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS626157

Other Notes

Small volumes of anti-CDK14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK14 purchase

MBS626157 is an antibody targeting CDK14. Also known as PFTK1, NT (Cell Division Protein Kinase 14, Cyclin-dependent Kinase 14, CDK14, KIAA0834, PFTAIRE1, hPFTAIRE1, Serine/threonine Protein Kinase PFTAIRE-1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDK14. It may not necessarily be applicable to this product.

NCBI GI #
223460492
NCBI GeneID
5218
UniProt Primary Accession #
O94921
UniProt Secondary Accession #
Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0; A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2
UniProt Related Accession #
O94921
NCBI Official Full Name
PFTK1 protein
NCBI Official Synonym Full Names
cyclin-dependent kinase 14
NCBI Official Symbol
CDK14
NCBI Official Synonym Symbols
PFTK1; KIAA0834; PFTAIRE1
UniProt Protein Name
Cyclin-dependent kinase 14
UniProt Synonym Protein Names
Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
CDK14
UniProt Synonym Gene Names
KIAA0834; PFTK1
UniProt Entry Name
CDK14_HUMAN
NCBI Protein Information
cyclin-dependent kinase 14; hPFTAIRE1; OTTHUMP00000025267; OTTHUMP00000068098; OTTHUMP00000196961; PFTAIRE protein kinase 1; cell division protein kinase 14; serine/threonine-protein kinase PFTAIRE-1

NCBI Summary for CDK14

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM]

UniProt Comments for CDK14

CDK14: a protein kinase of the CDK family. May play a role in meiosis as well as in neuron differentiation and/or function. Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Two alternatively spliced isoforms have been described.

Protein type: Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; EC 2.7.11.22; Cell cycle regulation; CMGC group; CDK family; TAIRE subfamily; CDK/TAIRE subfamily

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: cyclin binding; protein binding; cyclin-dependent protein kinase activity; ATP binding

Biological Process: Wnt receptor signaling pathway; cell division; regulation of cell cycle; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation
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Research Articles on CDK14

1. Novel biological cascade that involved the phosphorylation activation of CaD by PFTK1 kinase in promoting formation of actin stress fibers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDK14 antibody

 Reference Product  PubMed Publications
 CDKN1A antibody  >1 publications with CDK14 and CDKN1A
 CCND3 antibody  >1 publications with CDK14 and CCND3

Organs/Tissues associated with anti-CDK14 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with CDK14 and Liver
 Blood Antibodies  >1 publications with CDK14 and Blood
 Brain Antibodies  >1 publications with CDK14 and Brain
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