• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Calpain I, Large Subunit (CAPNS1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626200

Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Type I Calpain requires micromolar amounts of calcium, while type II calpain requires millimolar amounts of calcium. More details

$585 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Calpain I, Large Subunit (CAPNS1), Polyclonal Antibody
Full Product Name
Calpain I, Large Subunit (Mu Calpain, Protein Kinase C Activating Factor)
Product Gene Name
Product Synonym Names
Anti -Calpain I, Large Subunit (Mu Calpain, Protein Kinase C Activating Factor)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 50% glycerol, 1% BSA, 0.02% sodium azide.
Purity/Purification
Serum
Diluted serum
Specificity
Recognizes the large subunit (80kD) of human calpain I. It does not recognize the smaller subunit of human calpain I.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
28,316 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (36630918..36641255). Location: 19q13.12
OMIM
114170
3D Structure
ModBase 3D Structure for P04632
Immunogen
Human Calpain I (large subunit)

Product Categories/Family for anti-CAPNS1 antibody

Applications Tested/Suitable for anti-CAPNS1 antibody
Western Blot (WB)
Application Notes for anti-CAPNS1 antibody
Suitable for use in Western Blotting.
Dilution: Western Blotting: 0.5-1mg/ml

Other Notes

Small volumes of anti-CAPNS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAPNS1 purchase

MBS626200 is an antibody targeting CAPNS1. Also known as Calpain I, Large Subunit (Mu Calpain, Protein Kinase C Activating Factor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CAPNS1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
calpain small subunit 1
NCBI Official Synonym Full Names
calpain, small subunit 1
NCBI Official Symbol
CAPNS1
NCBI Official Synonym Symbols
30K; CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4
UniProt Protein Name
Calpain small subunit 1
UniProt Synonym Protein Names
Calcium-activated neutral proteinase small subunit; CANP small subunit; Calcium-dependent protease small subunit; CDPS; Calcium-dependent protease small subunit 1; Calpain regulatory subunit
Protein Family
UniProt Gene Name
CAPNS1
UniProt Synonym Gene Names
CAPN4; CAPNS; CSS1; CANP small subunit; CDPS
UniProt Entry Name
CPNS1_HUMAN
NCBI Protein Information
calpain small subunit 1; CANP small subunit; calpain regulatory subunit; calpain, small polypeptide; calpain 4, small subunit (30K); calcium-dependent protease, small subunit; calcium-dependent protease small subunit 1; calcium-activated neutral proteinase small subunit

NCBI Summary for CAPNS1

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CAPNS1

CAPNS1: Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Protein type: Protease; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of cell proliferation; proteolysis
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000