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Macrophage Inflammatory Protein 3 Beta (CCL19) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626204

MIP-3 beta acts as a chemoattractant for T and B lymphocytes, dendritic cells, NK cells and myeloid progenitor cells, through specific binding to CCR7, a G-protein coupled receptor known to be up-regulated by Epstein-Barr virus infected B cells and… More details

$775 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Macrophage Inflammatory Protein 3 beta (CCL19), Polyclonal Antibody
Full Product Name
Macrophage Inflammatory Protein 3 beta, Human (MIP-3b, Exodus-3, ELC)
Product Gene Name
anti-CCL19 antibody
Product Synonym Names
Anti -Macrophage Inflammatory Protein 3 beta, Human (MIP-3b, Exodus-3, ELC)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human MIP-3 beta
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Molecular Weight
10,993 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (34689567..34691274, complement). Location: 9p13
3D Structure
ModBase 3D Structure for Q6IBD6
Immunogen
Highly purified recombinant human MIP-3 beta

Product Categories/Family for anti-CCL19 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-CCL19 antibody
ELISA (EL/EIA), Western Blot (WB), Neutralization
Application Notes for anti-CCL19 antibody
Suitable for use in Neutralization, ELISA and Western Blot.
Dilution: Neutralization: 2.7-4.0ug/ml yields one-half maximal inhibition [ND50] of the biological activity of hMIP-3-beta (100ng/ml).
ELISA: > 0.5ug/ml using 100ul/well antibody solution. Allows the detection of 0.2-0.4ng/well
Western Blot: 0.1-0.2ug/ml. The detection limit is 1.5-3.0ng/lane under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-CCL19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL19 purchase

MBS626204 is an antibody targeting CCL19. Also known as Macrophage Inflammatory Protein 3 beta, Human (MIP-3b, Exodus-3, ELC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL19. It may not necessarily be applicable to this product.

NCBI GI #
1791003
NCBI GeneID
6363
UniProt Primary Accession #
Q6IBD6
UniProt Related Accession #
Q6IBD6; Q99731
NCBI Official Full Name
macrophage inflammatory protein 3 beta
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 19
NCBI Official Symbol
CCL19
NCBI Official Synonym Symbols
ELC; CKb11; MIP3B; MIP-3b; SCYA19; MGC34433
UniProt Protein Name
CCL19 protein
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL19
UniProt Entry Name
Q6IBD6_HUMAN
NCBI Protein Information
C-C motif chemokine 19; exodus-3; CK beta-11; MIP-3-beta; OTTHUMP00000021295; OTTHUMP00000021296; EBI1 ligand chemokine; EBI1-ligand chemokine; CC chemokine ligand 19; beta chemokine exodus-3; beta-chemokine exodus-3; small-inducible cytokine A19; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; epstein-Barr virus-induced molecule 1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19

NCBI Summary for CCL19

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq]
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UniProt Comments for CCL19

CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR chemokine receptor binding; chemokine activity; chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding

Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; positive regulation of receptor-mediated endocytosis; activation of JNK activity; dendritic cell chemotaxis; cell communication; establishment of T cell polarity; positive regulation of T cell proliferation; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation
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Research Articles on CCL19

1. These results suggest a new combinatorial guiding mechanism by CCL19 and CCL21 for the migration and trafficking of CCR7 expressing leukocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL19 antibody

 Reference Product  PubMed Publications
 CCR7 antibody  >323 publications with CCL19 and CCR7
 CXCL13 antibody  >72 publications with CCL19 and CXCL13
 CCL22 antibody  >33 publications with CCL19 and CCL22
 CCR10 antibody  >4 publications with CCL19 and CCR10
 CCRL1 antibody  >3 publications with CCL19 and CCRL1
 CCBP2 antibody  >1 publications with CCL19 and CCBP2

Pathways associated with anti-CCL19 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-CCL19 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >101 publications with CCL19 and Inflammation
 Skin Diseases Antibodies  >32 publications with CCL19 and Skin Diseases
 Lung Diseases Antibodies  >31 publications with CCL19 and Lung Diseases
 Vascular Diseases Antibodies  >18 publications with CCL19 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >15 publications with CCL19 and Cardiovascular Diseases
 Carcinoma, Squamous Cell Antibodies  >14 publications with CCL19 and Carcinoma, Squamous Cell
 Liver Diseases Antibodies  >10 publications with CCL19 and Liver Diseases
 Lung Neoplasms Antibodies  >9 publications with CCL19 and Lung Neoplasms
 Atherosclerosis Antibodies  >8 publications with CCL19 and Atherosclerosis
 Liver Neoplasms Antibodies  >5 publications with CCL19 and Liver Neoplasms

Organs/Tissues associated with anti-CCL19 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >218 publications with CCL19 and Lymph Node
 Vascular Antibodies  >62 publications with CCL19 and Vascular
 Spleen Antibodies  >52 publications with CCL19 and Spleen
 Lung Antibodies  >46 publications with CCL19 and Lung
 Thymus Antibodies  >29 publications with CCL19 and Thymus
 Brain Antibodies  >16 publications with CCL19 and Brain
 Pancreas Antibodies  >15 publications with CCL19 and Pancreas
 Eye Antibodies  >13 publications with CCL19 and Eye
 Intestine Antibodies  >11 publications with CCL19 and Intestine
 Pharynx Antibodies  >9 publications with CCL19 and Pharynx
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