Rabbit Anti-CSTF2 Polyclonal Antibody – Cat# MBS626293

Western Blot analysis of NCI-H460 cell line lysates (35ug/lane) using MBS626293. CSTF2(arrow) was detected using the purified Pab.

Cleavage Stimulation Factor 2 (CSTF2) Antibody – Rabbit Polyclonal

Name: CSTF2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS626293
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626293

CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cleavage Stimulation Factor 2 (CSTF2), Polyclonal Antibody

Full Product Name

Cleavage Stimulation Factor 2, NT (Cleavage Stimulation Factor 64kD Subunit, CSTF 64kD Subunit, CF-1 64kD Subunit, CstF-64, CSTF2)

Product Gene Name

anti-CSTF2 antibody

Product Synonym Names

Anti -Cleavage Stimulation Factor 2, NT (Cleavage Stimulation Factor 64kD Subunit, CSTF 64kD Subunit, CF-1 64kD Subunit, CstF-64, CSTF2)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human CSTF2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

60,959 Da

Chromosome Location

Chromosome: X; NC_000023.10 (100075348..100095924). Location: Xq22.1

OMIM

600368

3D Structure

ModBase 3D Structure for P33240

Immunogen

Synthetic peptide selected from the N-terminal region of human CSTF2 (KLH).

Product Categories/Family for anti-CSTF2 antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-CSTF2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CSTF2 antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Other Notes

Small volumes of anti-CSTF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSTF2 purchase

MBS626293 is an antibody targeting CSTF2. Also known as Cleavage Stimulation Factor 2, NT (Cleavage Stimulation Factor 64kD Subunit, CSTF 64kD Subunit, CF-1 64kD Subunit, CstF-64, CSTF2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CSTF2. It may not necessarily be applicable to this product.

NCBI GI #

4557493

NCBI GeneID

1478

NCBI Accession #

NP_001316.1

UniProt Primary Accession #

P33240

UniProt Secondary Accession #

Q5H951; Q6LA74; Q8N502

UniProt Related Accession #

P33240

GenBank Nucleotide #

NM_001325.2

NCBI Official Full Name

cleavage stimulation factor subunit 2

NCBI Official Synonym Full Names

cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

NCBI Official Symbol

CSTF2

NCBI Official Synonym Symbols

CstF-64

UniProt Protein Name

Cleavage stimulation factor subunit 2

UniProt Synonym Protein Names

CF-1 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit

Protein Family

Cleavage stimulation factor

UniProt Gene Name

CSTF2

UniProt Entry Name

CSTF2_HUMAN

NCBI Protein Information

cleavage stimulation factor subunit 2; OTTHUMP00000024310; OTTHUMP00000234163; CF-1 64 kDa subunit; CSTF 64 kDa subunit; betaCstF-64 variant 2; cleavage stimulation factor 64 kDa subunit

NCBI Summary for CSTF2

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq]

UniProt Comments for CSTF2

CSTF2: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: nucleoplasm; mRNA cleavage and polyadenylation specificity factor complex; nucleus

Molecular Function: protein binding; RNA binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA polyadenylation; mRNA 3'-end processing; termination of RNA polymerase II transcription; mRNA cleavage

Research Articles on CSTF2

1. nuclear accumulation of CstF-64 depends on binding to CstF-77 not symplekin; interaction between CstF-64/CstF-64Tau and CstF-77 are important for maintenance of nuclear levels of CstF complex components and intracellular localization, stability, function

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CSTF2 antibody

Products by Pathway	Pathway Diagram
Cleavage Of Growing Transcript In The Termination Region Pathway antibodies	Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
Formation And Maturation Of MRNA Transcript Pathway antibodies	Formation And Maturation Of MRNA Transcript Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies	Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
Processing Of Capped Intronless Pre-mRNA Pathway antibodies	Processing Of Capped Intronless Pre-mRNA Pathway Diagram
Processing Of Intronless Pre-mRNAs Pathway antibodies	Processing Of Intronless Pre-mRNAs Pathway Diagram
RNA Polymerase II Transcription Pathway antibodies	RNA Polymerase II Transcription Pathway Diagram
RNA Polymerase II Transcription Termination Pathway antibodies	RNA Polymerase II Transcription Termination Pathway Diagram
Transcription Pathway antibodies	Transcription Pathway Diagram
MRNA 3'-end Processing Pathway antibodies	MRNA 3'-end Processing Pathway Diagram

Organs/Tissues associated with anti-CSTF2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with CSTF2 and Brain
Liver Antibodies	>1 publications with CSTF2 and Liver
Testis Antibodies	>1 publications with CSTF2 and Testis