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Semaphorin 5a (SEMA5A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626319

Semaphorin 5A belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Semaphorin 5A (SEMA5A), Polyclonal Antibody
Full Product Name
Semaphorin 5A (S106) (Semaphorin-F, Sema F, Semaphorin-5A, SEMAF, SEMA5A)
Product Gene Name
anti-SEMA5A antibody
Product Synonym Names
Anti -Semaphorin 5A (S106) (Semaphorin-F, Sema F, Semaphorin-5A, SEMAF, SEMA5A)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human Semaphorin 5A. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
120,615 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (9035138..9546233, complement). Location: 5p15.2
OMIM
609297
3D Structure
ModBase 3D Structure for Q13591
Immunogen
Synthetic peptide selected from the S106 region of human Semaphorin 5A (KLH).

Product Categories/Family for anti-SEMA5A antibody

Antibodies; Abs to Plexin; Semaphorin
Applications Tested/Suitable for anti-SEMA5A antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SEMA5A antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-SEMA5A antibody

Western blot analysis of Semaphorin 5A-S106 Antibody in mouse brain tissue lysates (35ug/lane). Semaphorin 5A (arrow) was detected using the purified Pab.
Rabbit Anti-SEMA5A Polyclonal Antibody – Cat# MBS626319

Western Blot (WB) of anti-SEMA5A antibody

Semaphorin 5A-S106 Antibody western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Semaphorin 5A antibody detected the Semaphorin 5A protein (arrow).
Rabbit Anti-SEMA5A Polyclonal Antibody, Western Blot (WB) – Cat# MBS626319

Other Notes

Small volumes of anti-SEMA5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEMA5A purchase

MBS626319 is an antibody targeting SEMA5A. Also known as Semaphorin 5A (S106) (Semaphorin-F, Sema F, Semaphorin-5A, SEMAF, SEMA5A). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEMA5A. It may not necessarily be applicable to this product.

NCBI GI #
147904700
NCBI GeneID
9037
NCBI Accession #
NP_003957.2
UniProt Primary Accession #
Q13591
UniProt Secondary Accession #
O60408; Q1RLL9; D3DTC6
UniProt Related Accession #
Q13591
GenBank Nucleotide #
NM_003966.2
NCBI Official Full Name
semaphorin-5A
NCBI Official Synonym Full Names
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
NCBI Official Symbol
SEMA5A
NCBI Official Synonym Symbols
semF; SEMAF; FLJ12815
UniProt Protein Name
Semaphorin-5A
UniProt Synonym Protein Names
Semaphorin-F
Protein Family
Semaphorin
UniProt Gene Name
SEMA5A
UniProt Synonym Gene Names
SEMAF
UniProt Entry Name
SEM5A_HUMAN
NCBI Protein Information
semaphorin-5A; sema F; semaphorin F; semaphorin-F; OTTHUMP00000115584

NCBI Summary for SEMA5A

This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.

UniProt Comments for SEMA5A

SEMA5A: a single-pass type I membrane protein that may act as positive axonal guidance cues.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: heparan sulfate proteoglycan binding; syndecan binding; axon guidance receptor activity; semaphorin receptor binding

Biological Process: axon guidance; nervous system development; positive regulation of actin filament depolymerization; axonal fasciculation; negative regulation of cell adhesion; negative regulation of axon extension involved in axon guidance; diencephalon development; patterning of blood vessels; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; blood vessel endothelial cell proliferation during sprouting angiogenesis; cell-cell signaling; positive chemotaxis; positive regulation of axon extension involved in axon guidance; positive regulation of endothelial cell proliferation; cell adhesion
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Research Articles on SEMA5A

1. The downregulation of SEMA5A in tumor tissue, both at the transcriptional and translational levels, was associated with poor survival among nonsmoking women with NSCLC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SEMA5A antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-SEMA5A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with SEMA5A and Neoplasms
 Parkinson Disease Antibodies  >5 publications with SEMA5A and Parkinson Disease
 Carcinoma Antibodies  >4 publications with SEMA5A and Carcinoma
 Stomach Neoplasms Antibodies  >3 publications with SEMA5A and Stomach Neoplasms
 Autistic Disorder Antibodies  >2 publications with SEMA5A and Autistic Disorder
 Adenocarcinoma Antibodies  >1 publications with SEMA5A and Adenocarcinoma
 Inflammation Antibodies  >1 publications with SEMA5A and Inflammation
 Lung Neoplasms Antibodies  >1 publications with SEMA5A and Lung Neoplasms

Organs/Tissues associated with anti-SEMA5A antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >27 publications with SEMA5A and Nerve
 Brain Antibodies  >13 publications with SEMA5A and Brain
 Embryonic Tissue Antibodies  >7 publications with SEMA5A and Embryonic Tissue
 Lung Antibodies  >3 publications with SEMA5A and Lung
 Stomach Antibodies  >3 publications with SEMA5A and Stomach
 Eye Antibodies  >3 publications with SEMA5A and Eye
 Bone Antibodies  >2 publications with SEMA5A and Bone
 Blood Antibodies  >2 publications with SEMA5A and Blood
 Muscle Antibodies  >1 publications with SEMA5A and Muscle
 Prostate Antibodies  >1 publications with SEMA5A and Prostate
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