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IRF5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626398

IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity.… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IRF5, Polyclonal Antibody
Full Product Name
IRF5, NT (Interferon Regulatory Factor 5, IRF-5)
Product Gene Name
anti-IRF5 antibody
Product Synonym Names
Anti -IRF5, NT (Interferon Regulatory Factor 5, IRF-5)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human IRF5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
56,044 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (128577994..128590089). Location: 7q32
OMIM
180300
3D Structure
ModBase 3D Structure for Q13568
Immunogen
Synthetic peptide selected from the N-terminal region of human IRF5 (KLH).

Product Categories/Family for anti-IRF5 antibody

Antibodies; Abs to Interferon
Applications Tested/Suitable for anti-IRF5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-IRF5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-IRF5 antibody

Western blot analysis of anti-IRF5 Antibody (N-term) in Ramos cell line lysates (35ug/lane). IRF5 (arrow) was detected using the purified Pab.
Rabbit Anti-IRF5 Polyclonal Antibody – Cat# MBS626398

Immunofluorescence (IF) of anti-IRF5 antibody

Confocal immunofluorescent analysis of IRF5 Antibody (N-term) with A549 cell followed by Alexa Fluor搴?489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-IRF5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS626398

Flow Cytometry (FC/FACS) of anti-IRF5 antibody

IRF5 Antibody (N-term) flow cytometry analysis of Ramos cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-IRF5 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS626398

Other Notes

Small volumes of anti-IRF5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF5 purchase

MBS626398 is an antibody targeting IRF5. Also known as IRF5, NT (Interferon Regulatory Factor 5, IRF-5). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF5. It may not necessarily be applicable to this product.

NCBI GI #
334883190
NCBI GeneID
3663
NCBI Accession #
NP_001229381.1
UniProt Primary Accession #
Q13568
UniProt Secondary Accession #
Q64GB1; Q64GB2; Q9BQF0; E7EQ16
UniProt Related Accession #
Q13568; Q1A7B4; Q64GA8; Q64GA9; Q64GB0; Q6RCM8
GenBank Nucleotide #
NM_001242452.1
NCBI Official Full Name
interferon regulatory factor 5 isoform e
NCBI Official Synonym Full Names
interferon regulatory factor 5
NCBI Official Symbol
IRF5
NCBI Official Synonym Symbols
SLEB10
UniProt Protein Name
Interferon regulatory factor 5
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF5
UniProt Entry Name
IRF5_HUMAN
NCBI Protein Information
interferon regulatory factor 5; IRF-5; OTTHUMP00000212904; OTTHUMP00000212905; OTTHUMP00000212907; OTTHUMP00000212910

NCBI Summary for IRF5

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq]
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UniProt Comments for IRF5

IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of interleukin-12 production; response to muramyl dipeptide; positive regulation of apoptosis; response to peptidoglycan; cytokine and chemokine mediated signaling pathway; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of interferon-alpha production

Disease: Systemic Lupus Erythematosus, Susceptibility To, 10; Inflammatory Bowel Disease 14
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Research Articles on IRF5

1. Data suggest that IRF5 gene polymorphism is a genetic factor influencing susceptibility to macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis, and IRF5 contributes to the pathogenesis of MAS in these patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRF5 antibody

 Reference Product  PubMed Publications
 IRF3 antibody  >26 publications with IRF5 and IRF3
 MYD88 antibody  >15 publications with IRF5 and MYD88
 TRAF6 antibody  >5 publications with IRF5 and TRAF6
 TBK1 antibody  >4 publications with IRF5 and TBK1
 IKBKE antibody  >1 publications with IRF5 and IKBKE

Pathways associated with anti-IRF5 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram

Diseases associated with anti-IRF5 antibody

 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >93 publications with IRF5 and Lupus Erythematosus, Systemic
 Arthritis, Rheumatoid Antibodies  >38 publications with IRF5 and Arthritis, Rheumatoid
 Inflammation Antibodies  >19 publications with IRF5 and Inflammation
 Neoplasms Antibodies  >17 publications with IRF5 and Neoplasms
 Scleroderma, Systemic Antibodies  >14 publications with IRF5 and Scleroderma, Systemic
 Inflammatory Bowel Diseases Antibodies  >8 publications with IRF5 and Inflammatory Bowel Diseases
 Fibrosis Antibodies  >7 publications with IRF5 and Fibrosis
 Lymphoma Antibodies  >5 publications with IRF5 and Lymphoma
 Liver Diseases Antibodies  >4 publications with IRF5 and Liver Diseases
 Cholestasis Antibodies  >3 publications with IRF5 and Cholestasis

Organs/Tissues associated with anti-IRF5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >59 publications with IRF5 and Blood
 Spleen Antibodies  >6 publications with IRF5 and Spleen
 Connective Tissue Antibodies  >5 publications with IRF5 and Connective Tissue
 Bone Marrow Antibodies  >3 publications with IRF5 and Bone Marrow
 Mouth Antibodies  >3 publications with IRF5 and Mouth
 Kidney Antibodies  >3 publications with IRF5 and Kidney
 Bone Antibodies  >3 publications with IRF5 and Bone
 Brain Antibodies  >2 publications with IRF5 and Brain
 Eye Antibodies  >1 publications with IRF5 and Eye
 Prostate Antibodies  >1 publications with IRF5 and Prostate
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