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Neurolysin (NLN) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626399

NLN (neurolysin) is a metalloproteinase of the MA(E) clade, in the M3 family. The name is derived from the ability to degrade neurotensin. The M3 family includes the structurally similar thimet oligopeptidase (EC 3.4.24.15), and contains the canonical… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Neurolysin (NLN), Polyclonal Antibody
Full Product Name
Neurolysin (Neurolysin, Mitochondrial, Angiotensin-binding Protein, Microsomal Endopeptidase, MEP, Mitochondrial Oligopeptidase M, Neurotensin Endopeptidase, NLN, AGTBP, KIAA1226)
Product Gene Name
Product Synonym Names
Anti -Neurolysin (Neurolysin, Mitochondrial, Angiotensin-binding Protein, Microsomal Endopeptidase, MEP, Mitochondrial Oligopeptidase M, Neurotensin Endopeptidase, NLN, AGTBP, KIAA1226)
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Neurolysin. Species Crossreactivity: mouse, rat.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
80,652 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (65018023..65125111). Location: 5q12.3
OMIM
611530
3D Structure
ModBase 3D Structure for Q9BYT8
Immunogen
Purified, E. coli-derived, recombinant human Neurolysin (aa38-704).

Product Categories/Family for anti-NLN antibody

Applications Tested/Suitable for anti-NLN antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-NLN antibody
Suitable for use in ELISA, Immunoprecipitation, and Western Blot.
Dilution: Western Blot: 1ug/ml
ELISA: 0.5-1ug/ml

SDS-Page of anti-NLN antibody

Detection of Neurolysin: Cell and tissue lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and immunoblotted with 1g/ml sheep anti-h/m/rNeurolysin.
Sheep Anti-NLN Polyclonal Antibody – Cat# MBS626399

Other Notes

Small volumes of anti-NLN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLN purchase

MBS626399 is an antibody targeting NLN. Also known as Neurolysin (Neurolysin, Mitochondrial, Angiotensin-binding Protein, Microsomal Endopeptidase, MEP, Mitochondrial Oligopeptidase M, Neurotensin Endopeptidase, NLN, AGTBP, KIAA1226). Reactive in Human, Mouse, Rat. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for NLN. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
neurolysin, mitochondrial
NCBI Official Synonym Full Names
neurolysin (metallopeptidase M3 family)
NCBI Official Symbol
NLN
NCBI Official Synonym Symbols
MEP; MOP; AGTBP; EP24.16; FLJ23002; KIAA1226; DKFZp564F123
UniProt Protein Name
Neurolysin, mitochondrial
UniProt Synonym Protein Names
Angiotensin-binding protein; Microsomal endopeptidase; MEP; Mitochondrial oligopeptidase M; Neurotensin endopeptidase
Protein Family
UniProt Gene Name
NLN
UniProt Synonym Gene Names
AGTBP; KIAA1226
UniProt Entry Name
NEUL_HUMAN
NCBI Protein Information
neurolysin, mitochondrial; OTTHUMP00000123454; OTTHUMP00000222651; endopeptidase 24.16; microsomal endopeptidase; neurotensin endopeptidase; angiotensin binding protein; angiotensin-binding protein; mitochondrial oligopeptidase M

NCBI Summary for NLN

This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.
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UniProt Comments for NLN

NLN: Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Belongs to the peptidase M3 family.

Protein type: Mitochondrial; Protease; EC 3.4.24.16

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: plasma membrane; mitochondrial intermembrane space

Molecular Function: metalloendopeptidase activity; metal ion binding; peptide binding

Biological Process: proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NLN antibody

 Reference Product  PubMed Publications
 NTS antibody  >1 publications with NLN and NTS
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